Health Effects of Trihalomethanes as Chlorinated Disinfection by Products: A Review Article
Commenced in January 2007
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Health Effects of Trihalomethanes as Chlorinated Disinfection by Products: A Review Article

Authors: M. R. Mohamadshafiee, L. Taghavi

Abstract:

Trihalomethanes (THMs) were among the first disinfection byproducts to be discovered in chlorinated water. The substances form during a reaction between chlorine and organic matter in the water. Trihalomethanes are suspected to have negative effects on birth such as, low birth weight, intrauterine growth retardation in term births, as well as gestational age and preterm delivery. There are also some evidences showing these by-products to be mutagenic and carcinogenic, the greatest amount of evidence being related to the bladder cancer. However, there exist inconsistencies regarding such effects of THMs as different studies have provided different results in this regard. The aim of the present study is to provide a review of the related researches about the above mentioned health effects of THMs.

Keywords: Trihalomethans, by-products, disinfection, carcinogenic

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1059791

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References:


[1] O. Our planet our health: report of the WHO commission health and environment. World Health Organization, 1992, Geneva.
[2] S. D. Richardson, M. J. Plewa, E. D. Wagner, R. Schoeny, D. M. DeMarini, Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: A review and roadmap for research, 636, PP 178-242, 2007.
[3] S.D. Richardson, "Disinfection by-products and other emerging contaminants in drinking water", Trends in Analytical Chemistry, vol 22. no 10, pp. 666- 692, 2003.
[4] G. Becher, "Drinking water chlorination and health", Acta Hydrochem. Hydrobiol, 27 (1999) 100-102.
[5] J.J. Rook, "Formation of haloforms during chlorination of natural waters, Water Treat". Exam. Vol 23 pp. 234-243, 1974.
[6] M. Casals, "Trihalomethanes Contaminants in Drinking Water ", available online at http:// holisticwellnesshow.com/. March 3rd, 2010.
[7] S.D. Richardson, J.E. Simmons, G. Rice, Environ, Sci. Technol. Vol 36, pp. 198-202, 2002.
[8] F. Benoit, H. Nicolidakis, K. Cardinall, C. Alleyne, B. Mori, Proc. Am. Soc. Mass Spectrom, pp. 212-215, 1997.
[9] L.C. Backer, D.L. Ashley, M.A. Bonin, F.L. Cardinali, S.M. Kieszak, J.V.J. Wooten, Expos. Anal. Environ, Epidemiology, vol 10 pp 321-325, 2000.
[10] C.P.Weisel, H. Kim, P. Haltmeier, J.B. Klotz, "Environ. Health Perspect ", vol 107, pp. 103-109, 1999.
[11] H. George, What are Trihalomethanes?, WiseGEEK, 2003.
[12] IARC, Monograph on the Evaluation of Carcinogenic Risk to Human: Chlorinated Drinking Water, Chloroform By-product, Some Other Halogenated Compound Cobalt and Cobalt Compound, 52 Lyon IARC, 1991.
[13] S.R. Bielmeier, D.S. Best, D.L. Guidici, M.G. Narotsky, "Pregnancy loss in the rat caused by bromodichloromethane ", Toxicol. Sci. vol 59, pp 309-315, 2001.
[14] K.Waller, S.H. Swan, G. Delorenze, B. Hopkins, " Trihalomethane in drinking water and spontaneous abortion ", Epidemiology. Vol 9, pp. 134-140, 1998.
[15] R.S. Marris, A.M. Audet, I.F. Angelildo, T.F. Chalmers, P. Mosteller, "Chlorination evaluation by product and cancerÔÇöa meta analysis ", Am. J. Public Health, vol 82, pp. 955-963, 1992.
[16] J. Tibbets, What's in the Water: The Disinfectant Dilemma. Environmental Health Perspectives 1995. 103(1), available online at: http://ehpnet1.niehs.nih.gov/members/1995/103-1/focus1.html
[17] M.E. Hildesheim, K.P. Cantor, C.F. Lynch, M. Dosemeci, J. Lubin, M. Alavanja, & G. Craun Drinking water source and chlorination byproducts: risk of colon and rectal cancers. Epidemiology, vol 9, no 1, pp. 28-36, 1998.
[18] McGeehin MA, Reif JS, Becher JC, Mangione EJ, "Case-control study of bladder cancer and water disinfection methods in Colorado ", Am J Epidemiol, vol 138, no 7, pp. 492-501, 1993.
[19] W.D. King, L.D. Marrett, Case-control study of bladder cancer and chlorination by-products in treated water. Cancer Causes and Control, vol 7, pp. 596-604, 1996.
[20] K.P. Cantor, C.F. Lynch, M. Hildeshiem, Chlorinated drinking water and risk of glioma: a case-control study in Iowa, USA. Epidemiology, vol 7, no 4, S83, 1996.
[21] D.M. Parkin, F. Bray, J. Farlay, P. Pisani, Global Cancer Statistics, CA Cancer J Clin, vol 55, pp. 74-108, 2002.
[22] E.F. Heineman, S.H. Zahm, J.K. Mclaughlin, J.B.Vaught, Increased risk of colorectal-cancer among smokers-resluts of a 26-year follow-up of U.S. veterans and a review, Int J Cancer, vol 59, no 6, pp. 728-738, 1994.
[23] P.H. Chyou, A.M. Nomura, G.N. Stemmermann, A prospective study of colon and rectal cancer amoung Hawaii Japanese men, Ann Epidemiol, pp 6, no 4, pp. 276-282, 1996.
[24] J.L. Freudenheim, S. Graham, J.R. Marshall, B.P. Haughey, G. Wilkeson, A case-control study of diet and rectal cancer in Western New York, Am J Epidemiol, vol 131, no 4, pp. 612-624, 1990.
[25] A. Pedersen, C. Johansen, M. Gronbaek, Relations between amount and type of alcohol and colon and rectal cancer in a Danish population based cohort study. Gut, vol 52, no 6, pp. 861-867, 2003.
[26] M.L. Slattery, C. Sweeney, M. Murtaugh, K.N. Ma, B.J. Caan, J.D. Potter, R.Wolff, Associations between vitamin D, vitamin D receptor gene and the androgen receptor gene with colon and rectal cancer. Int J Cancer, vol 118, no 12, pp. 3140-3146, 2006.
[27] E. Weiderpass, H. Vainio, T. Kauppinen, K. Vasama-Neuvonen, T. Partanen, E. Pukkala, Occupational exposures and gastrointestinal cancers among Finnish women. J Occup Environ Med, vol 45, no 3, pp. 305-315, 2003.
[28] K.B. Michels, E. Giovannucci, K.J. Joshipura, B.A. Rosner, M.J. Stampfer, C.S. Fuchs, G.A. Colditz, F.E. Speizer, W.C. Willet, Prospective study of fruit and vegetable consumption and incidence of colon and rectal cancers, J Natl Cancer Inst, vol 92, no 21, pp. 1740- 1752, 2000.
[29] A. Chao, M.J. Thun, C.J. Connell, M.L. McCullough, E.J. Jacobs, W.D. Flanders, C. Rodriguez, R. Sinha, E.E. Calle, Meat consumption and risk of colorectal cancer, JAMA, vol 293, no 2, pp. 172-182, 2005.
[30] M.E. Hildesheim, et al. "Drinking Water Source and Chlorination Byproducts II. Risk of Colon and Rectal Cancer". Epidemiology. Vol 9, no 1, pp. 29-35, 1998.
[31] IARC, Monographs on the Evaluation of Carcinogenic Risks to Humans. Some Chemicals that Cause Tumours of the Kidney or Urinary Bladder in Rodents and Some Other Substances, International Agency for Research on Cancer, 73 Lyon, France, 1999.
[32] IARC, Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide, International Agency for Research on Cancer,71 Lyon, France, 1999.
[33] IARC, Monographs on the Evaluation of Carcinogenic Risks to Humans. Coffee, Tea, Mate, Methylxanthines and Methylglyoxal, International Agency for Research on Cancer, 51Lyon, France, 1991.
[34] D.R. Geter, M.H. George, T.M. Moore, S. Kilburn, G. Huggins-Clark, A.B. DeAngelo, Vehicle and mode of administration effects on the induction of aberrant crypt foci in the colons of male F344/N rats exposed to bromodichloromethane, J. Toxicol. Environ. Health A, vol 67,pp. 23-29, 2005.
[35] IARC, Monographs on the Evaluation of Carcinogenic Risks to Humans. Some Chemicals that Cause Tumours of the Kidney or Urinary Bladder in Rodents and Some Other Substances, vol. 73, International Agency for Research on Cancer, Lyon, France, 1999.
[36] IARC, Monographs on the Evaluation of Carcinogenic Risks to Humans. Some Chemicals that Cause Tumours of the Kidney or Urinary Bladder in Rodents and Some Other Substances, vol. 73, International Agency for Research on Cancer, Lyon, France, 1999.
[37] J.L. Larson, D.C. Wolf, & B.E. Butterworth, Induced cytolethality and regenerative cell proliferation in the livers and kidneys of male B6C3F1 mice given chloroform by gavage. Fundam Appl Toxicol, vol 23, pp. 537-543, 1994.
[38] J.L. Larson, D.C. Wolf, & B.E. Butterworth, Induced cytotoxicity and cell proliferation in the hepatocarcinogenicity of chloroform in female B6C3F1 mice: Comparison of administration by gavage in corn oil vs. ad libitum in drinking water. Fundam Appl Toxicol, vol 22, no 1, pp. 90- 102, 1994.
[39] D.C. Wolf, B.E. Butterworth, Risk assessment of inhaled chloroform based on its mode of action, Toxicol. Pathol. Vol 25, pp. 49-52, 1997.
[40] G.C. Hard, G.A. Boorman, D.C. Wolf, Re-evaluation of the 2- year chloroform drinking water carcinogenicity bioassay in Osborne-Mendel rats supports chronic renal tubule injury as the mode of action underlying the renal tumor response, Toxicol. Sci. vol 53, pp. 237-244, 2000.
[41] M.V. Templin, J.L. Larson, B.E. Butterworth, K.C. Jamison, J.R. Leininger, S. Mery, K.T. Morgan, B.A. Wong, D.C. Wolf, A 90-day chloroform inhalation study in F-344 rats: profile of toxicity and relevance to cancer studies, Toxicol. Sci. vol 32, pp. 109-125, 1996.
[42] T.L. Leavens, B.C. Blount, D.M. DeMarini, M.C. Madden, J.L. Valentine, M.W. Case, L.K. Silva, S.H. Warren, N.M. Hanley, R.A. Pegram, Disposition of bromodichloromethane in humans following oral and dermal exposure, Toxicol. Sci. vol 99, pp. 432-445, 2007.
[43] M.K. Ross, R.A. Pegram, In vitro biotransformation and genotoxicity of the drinking water disinfection byproduct bromodichloromethane: DNA binding mediated by glutathione transferase theta 1-1, Toxicol. Appl. Pharmacol. Vol 195, pp. 166-181, 2004.
[44] M.K. Ross, R.A. Pegram, Glutathione transferase theta 1-1- dependent metabolism of the water disinfection byproduct bromodichloromethane, Chem. Res. Toxicol. Vol 16, pp. 216-226, 2003.
[45] T. Keegar, H. Whitaker, M.J. Nicewenknijsen, M.B. Toledanar, P. Ellvot, J. Fawell, M. Wilkirson, N. Best, Use of routinely collected data on trihalomethane in drinking water for epidemiological purpose, Occup. Environ. Med. Vol 58, pp. 447-452, 2001.
[46] M.J .Nieuwenhuisjen, M. Toledano, N. Eaton, et al, Chlorination disinfection by-products in water and their association with adverse reproductive outcomes: a review. Occup. Environ. Med, vol 57, pp. 73- 85, 2000.
[47] WHO, Guidelines for drinking-water quality, Addendum to Volume 2 (WHO/EOS/98.1): Health criteria and other supporting information, 1998.
[48] J.M. Wright, J. Schwartz , D.W. Dockery, Effect of trihalomethane exposure on fetal development, Occup Environ Med, vol 60, no 3, pp. 173-80, 2003.
[49] M.I. Cedergren, A.J. Selbing, O. Löfman, B.A. K├ñllen, Chlorination byproducts and nitrate in drinking water and risk for congenital cardiac defects, Environ Res, vol 89, pp. 124-130, 2002.
[50] G.M. Shaw, D. Ranatunga, T.Quach, E. Neri, A. Correa, R.R. Neutra, Trihalomethane exposures from municipal water supplies and selected congenital malformations. Epidemiology, vol 14, pp. 191-199, 2003.
[51] B.F. Hwang, P. Magnus, J.J.K. Jaakkola, Risk of specific birth defects in the relation to chlorination and among of the natural organic matter in the water supply, Am J Epidemiol, vol 156, pp. 374-382, 2002.
[52] M.j. Nieuwenhuijsen, M.B. Toledano, J. Bennett, N. Best, P. Hambly, C. de Hoogh, D. Wellesley, P.A. Boyd, L. Abramsky, N. Dattani, J. Fawell, D. Briggs, L. Jarup, P. Elliott, Chlorination disinfection by-products and risk of congenital anomalies in England and Wales. Environ Health Perspect, vol 16 pp. 216-222, 2008.
[53] G.R. Klinefelter, J.D. Suarez, N.L. Roberts, & A.B. DeAngelo, Preliminary screening for the potential of drinking water disinfection by products to alter male reproduction. Reprod Toxicol, vol 9, pp. 571-578, 1996.
[54] L. Dodds , W. King, Relation between trihalomethane compounds and birth defects, Occup Environ Med. Vol 58, no 7, pp. 443-446, 2001.
[55] M.J. Plewa, E.D. Wagner, M.G. Muellner, K.M. Hsu, S.D. Richardson, Comparative mammalian cell toxicity of N-DBPs and C-DBPs, in: T. Karanfil, S.W. Krasner, P. Westerhoff, Y. Xie (Eds.), Occurrence, Formation, Health Effects and Control of Disinfection By-products in Drinking Water, American Chemical Society, Washington, DC, in press.
[56] R.A. Pegram, M.E. Andersen, S.H. Warren, T.M. Ross, L.D. Claxton, Glutathione S-transferase -mediated mutagenicity of trihalomethanes in Salmonella typhimurium: contrasting results with bromodichloromethane or chloroform, Toxicol. Appl. Pharmacol. Vol 144, pp. 183-188, 1997.
[57] D.M. DeMarini, M.L. Shelton, S.H. Warren, T.M. Ross, J.Y. Shim, A.M. Richard, R.A. Pegram, Glutathione S-transferase- mediated induction of GC ! AT transitions by halomethanes in Salmonella, Environ. Mol. Mutagen. Vol 30, pp. 440-447, 1997.
[58] M.J. Plewa, E.D. Wagner, A.C. Kim, R. Nelson, S.D. Richardson, Mammalian Cell Cytotoxicity and Genotoxicity of New Drinking Water DBPs, Presentation, Environ. Mutagen Soc. Conf, Miami Beach, FL, USA, 2003.