Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 30172
Investigation of Anti-Inflammatory, Antipyretic and Analgesic Effect of Yemeni Sidr Honey

Authors: Aman Ahmed Alzubier, Patrick Nwabueze Okechukwu

Abstract:

Traditionally, Yemini Sidr honey has been reported to cure liver problems, stomach ulcers, and respiratory disorders. In this experiment, we evaluated Yemeni Sidr honey for its ability to protect inflammations caused by acetic acid and formalin -induced writhing, carrageenan and histamine-induced paw oedema in experimental rat model. Hyperpyrexia, membrane stabilizing activity, and phytochemical screening of the honey was also examined. Yemini Sidr Honey at (100, 200 and 500 mg/kg) exhibited a concentration dependant inhibition of acetic acid induced and formalin induced writhing, paw oedema induced by carrageenan & histamine, and hyperpyrexia induced by brewer's yeast, it also inhibited membrane stabilizing activity. Phytochemical screenings of the honey reveal the presence of flavonoids, steroid, alkaloids, saponins and tannins. This study suggested that Yemeni Sidr honey possess very strong antiinflammatory, analgesic and antipyretic effects and these effects would be a result of the phytochemicals present.

Keywords: Anti-inflammatory, Analgesic, Carrageenan, Aceticacid, Histamine, Yemini Sidr Honey

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1330265

Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 3419

References:


[1] Al-Mamary, M., Al-Meeri, A., AL-Habori, M., (2002). Antioxidant activities and total phenolics of different types of honey. Nutrition Research, 22, 1041-1047.
[2] Basualdo, C., Sgroy, V., Finola, M. S., Marioli, J. M., (2007). Comparison of the antibacterial activity of honey from different provenance against bacteria usually isolated from skin wounds. Veterinary Microbiology. 124, 375-381.
[3] Gomes, S., Dias, L. G., Moreira, L. L., Rodrigues, P., Estevinho, L., (2009). Physicochemical, microbiological and antimicrobial properties of commercial honeys from Portugal.Food and Chemical Toxicology. 48, 544-548.
[4] White, J.W. Jr., (1975).Composition of Honey.In : Honey : a comprehensive survey. (Crane E, ed) Heinemann,London, 180-194
[5] Collier, H.O.J., Dinneen, L.C, Johnson,C.A., Schneider, C., (1968).The abdominal constriction response and its suppression by analgesic drugs in the mouse. British Journal of pharmacology and chemotherapy 32,295-310.
[6] Fontenele,J.B., Viana, G.S.B., Xavier-Filho,J., Alencar, J.W., (1996). Anti-inflammatory and analgesic activity of a water-soluble fraction from shark cartilage.Brazilian Journal of Medicinal and Biology Research 29, 643-464.
[7] Koster, R., Anderson, M., De Beer, E.J., (1959). Acetic acid and analgesic screening. Proceedings of the Society for Experimental Biology and Medicine 18, 412-415.
[8] Santos, A.R., Calixto,J.B.,(1997). Further evidence for the involvement of tachykinin receptor subtypes in formalin and capsaicin models of pain in mice. Neuropeptides 31,381- 389.
[9] Vilela, F.C., Padilha, M.M., Dos Santos-E-Silva, L., Alves-da-silva, G., Giusti-Paiva, A., (2009). Evaluation of the antinociceptive activity of extracts of sonchusoleraceus L. in mice. Journal of Enthopharmacology 124, 306-310.
[10] Winter, C.A., Risley, E.A., Nuss, G.W., (1962).Carrageenan-induced oedema in hind paw of the rat as an assay for anti-inflammatory drugs. Proceeding of the society for Experimental Biology and Medicine 111,544-547.
[11] Birch, P.J., Harrison, S.M., Hayes, A.G., Rogers, H.,Tyers, M.B., (1992). The non-peptide NK1 receptor antagonist,(+/)-CP-96,345, produces antinociceptive and anti-edema effects in the rat. Br. J. Pharmacol.105,508-510.
[12] Al-Ghamdi, M.S., (2001). The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa. J Ethnopharmacol ;76:45-8.
[13] Smith, P. K. & Hamburger, W. E. (1935). The ratio of the Toxicity of Acetanilid to its Antipyretic Activity in Rat. J. Pharmacol. Exp. Ther., 54, 346-351.
[14] Makonnen, E.,Makonnen, A.,Debella, L.,Zerihun, D.,Abebe,F and Teka, F, (2003). Antipyretic properties of the aqueous and ethanol extracts of the leaves of Ocimum suave and Ocimumlamiifolium in mice, Journal of Ethnopharmacology 88, pp. 85-91.
[15] Sulaimana,M.R.,.Perimala,E.K.,Akhtarb,M.N.,Mohamada,A.S. ,Khalida,M.H.,Tasripa,N.A.,Mokhtarb,F.,Zakariaa,Z.A.,Lajisb,N.H. andIsrafa, D.A., (2010). Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice. Fitoterapia 81(7) 855- 858.
[16] Sadique, J., Al-Raobah, N.A., Baghaith, M.F., El-Gindy, A.R., (1989). The bioactivity of certain medicinal plants on the stabilization of red blood cell membrane system.Fitoterapia LX, 525-532.
[17] Oyedapo, O.O., Famurewa, A.J., (1995). Antiprotease and membrane stabilizing activity of extracts of Fagarazanthoxyloides, Olaxsubscorpioides and Tetrapleuratetraptera. International Journal of Pharmacognosy33, 65-69.
[18] Odebiyi, O.O., Sofowora, E.A., (1978). Phytochemical screening of Nigerian medicinal plants II. Lloydia, Ohio 41, 234- 246.Kumar,A.,Llavarasan,R.,Jayachandran,T.,Decarama,M.,Aravindhan ,P.,Padmanabhan,N.and Krishan,M.R.V.,(2009). Phytochemical Investigation on Tropical plants,Syzgiumcumnini from Kattuppalayam ,Erode District,TamilNaclu,south India. Pakistan Journal of Nutrition, 8(1), 83-85. Additional reference
[19] Vidyalashmi, K., Kamalakannan,P., Viswanathan, S., Ramaswamy, S., (2010).Antinociceptive effect of certain dihydroxy flavones in mice. Pharmacology, Biochemistry and Behavior 96, 1-6.
[20] Collier , H.O., Dinneen, L.C.,Johnson,C.A., Schneider, C., ( 1968).The abdominal constriction response and its suppression by analgesic drugs in the mouse. British Journal of pharmacology and chemotherapy 32, 295-310.
[21] Deradt, R., Jougney, S., Benzoni, J., Peterfalvi, M., (1980).Release of prostaglandins E and F in an algogenic reaction and its inhibition .European journal of pharmacology 61, 17-24.
[22] Martinez, V., Thakur, S., Mogil, J.S., Tache, Y., Mayer, E.A., 1999.Differential effects of chemical and mechanical colonic irritation on behavioral pain response to intraperitoneal acetic in mice. Pain 81, 163-185.
[23] Julius, D., Basbaum, A.I., (2001). Molecular mechanism of nociception .Nature 413, 203-210.
[24] Hunskaar, S., Hole, K., (1987) .The formalin test in mice:dissociation between inflammatory and non-inflammatory pain. Pain 30, 130-114.
[25] Tjolsen, A., Berge, O.G., Hunskaar, S., Roslan, J.H., Hole,K., (1992).The formain test: an evaluation of the method.Pain 51, 5-17.
[26] Crunkhorn P, Meacock S. C. R., (1971). Mediators of the inflammation induced in the rat paw by carrageenan. Br J Pharmacol. 42(3): 392-402.
[27] Van Arman, C. G., Begany A. J., Miller, L. M. andPless, H. H. (2002). Some details of the inflammations caused by yeast and carrageenin (with appendix on kinetics of the reaction). J. Neurosci. 22:6208-6217.
[28] Ozaki, Y., (1990). Antiinflammatory effect of Curcuma xanthorrhiza ROXB.and its active principles . Chemical and pharmaceutical bulletin.1045-1048 (Tokyo).
[29] Babior,B.M, Kipnes,R.S, Curnutte, J.T. (1973). The production by leucocytes of superoxide, a potential bactericidal agent. J Clin Invest, 52: 741-4.
[30] Sethi, S., Singh, M.P., Dikshit, M., (2000). Mechanism involved in the augmentation of arachidonic acid-induced free radicalgeneration from rat neutrophils following hypoxia-reoxygenation. Trom Res 98:445-50.
[31] Latenti, A., Ianaro, A., Moncada, S., Di Rosa, M.,(1992).Modulation of acute inflammation by endogenous nitric oxide. Eur J Pharmacol 211:177-86.
[32] Di Rosa, M., Giroud, J.P., Willoughby, D.A., (1971).Studies of mediators of the acute inflammatory response induced in rats indifferent site by carrageenan and turpentine. J Pathol 104: 15-21.
[33] Abramson, S.B., Weissman, G., (1989). The mechanism of action of nonsteroidal anti-inflammatory drugs. Arthritis Rheum 32: 1-9.
[34] McCord, J.M., (1974). Free radicals and inflammation: Protection of synovial fluid by superoxidedismutase. Science 185: 529-31.
[35] Salvemini, D., Wang, Z.O., Bourdon, D.M., Stern, M.K., Currie, M.G., Manning, P.T.,(1996). Evidence of peroxynitrite involvement in the carrageenan-induced rat pawoedema.Eur J pharmacol 303: 217-20.
[36] Cuzzocrea, S., Zingarelli, B., Gilard, E., Hake, P., Salzman, A.L., Szabo, C.,(1998). Antiinflammatory effect of mercapoethylguanidine, a combined inhibitor of nitricoxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation .Free RadicBiolMed 24: 450-9.
[37] Al-Ghamdi, M.S.,(2001).The anti-inflammatory ,analgesic and antipyretic activity of Nigella sativa .J Ethanopharmacol ,76:45-8 .
[38] Hess, S.M., Millonig, R.C., (1972) .Assay for anti-inflammatory drugs .In: Lepow, I.H., Ward,P.A., (Eds.),Inflammation ,Mechanisms and control. Publication of Academic Press, London.
[39] Menuka, A.,Thabrew, I., Lakshmi, A., Shiroma, H., (2010). Antiinflammatory activity of Trichosanthescucumerina Linn.in rats .Journal of Ethnopharmacology 131:538-543.
[40] Aitadafoun, M., Mounieri, C., Heyman, S.F., Binistic, C., Bon, C., Godfroid, J., (1996).4-Alkoxybenzamidines as new potent phospholipase A2 inhibitors.Biochemical pharmacology 51, 737-742.