Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 30373
Tuning Neurons to Interaural Intensity Differences Using Spike Timing-Dependent Plasticity

Authors: Bertrand Fontaine, Herbert Peremans

Abstract:

Mammals are known to use Interaural Intensity Difference (IID) to determine azimuthal position of high frequency sounds. In the Lateral Superior Olive (LSO) neurons have firing behaviours which vary systematicaly with IID. Those neurons receive excitatory inputs from the ipsilateral ear and inhibitory inputs from the contralateral one. The IID sensitivity of a LSO neuron is thought to be due to delay differences between both ears, delays due to different synaptic delays and to intensity-dependent delays. In this paper we model the auditory pathway until the LSO. Inputs to LSO neurons are at first numerous and differ in their relative delays. Spike Timing-Dependent Plasticity is then used to prune those connections. We compare the pruned neuron responses with physiological data and analyse the relationship between IID-s of teacher stimuli and IID sensitivities of trained LSO neurons.

Keywords: Interaural difference, lateral superior olive, spike time-dependent plasticity

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1057117

Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1150

References:


[1] Pickles, J.O.: An introduction to the physiology of hearing, London: Academic Press (1982)
[2] Tollin, D.J.: The Lateral Superior Olive: a Functional Role in Sound Source Localization. Neuroscientist, vol. 9(2) (2003) 127-143
[3] Schaette, R., Gollisch T., Herz, A.: Spike-train vairability of auditory neurons in vivo: dynamic responses follow predicitions from constant stimuli. J. Neurophysiology, vol. 93 (2005) 3270-3281
[4] Park, T.J., Grothe, B., Park, G.D., Schuller, G., Koch, U.: Neural delays shape selectivity to interaural differences in the lateral superior olive. J. Neuroscience, vol. 16(20) (1996) 6554-6566
[5] Park, T.J, Monsivais P., and Park, G.D.: Processing of interaural intensity differences in the LSO: role of the interaural threshold differences. J. Neurophysiology, vol. 77 (1997) 2863-2878
[6] Heil, P., Irvine, D.: First-spike timing of auditory-nerve fibers and comparison with auditory cortex. Neurophy., vol. 78 (1997) 2438-2454
[7] Park, T.J.: Latency as a function of intensity in auditory neurons: influences of central processing. Hear. Res., vol. 148 (2000) 107-123
[8] van Hemmen, J.L., Leibold C.: Spiking neurons learning phase delays: how mammals may develop auditory time difference sensitivity. Physical Review Letters, Vol. 94. (2005)
[9] Sanes, D.H., Friauf, E.: Development and influence of inhibition in the lateral superior olivary nucleus. Hearing Research, vol. 147, (2000) 46-58
[10] Sanes, D.H.: An in vitro analysis of sound localization mechanisms in the gerbil lateral superior olive. J. Neuroscience, vol. 10, (1990) 3494-3506
[11] Gestner, W., Kistler, W.N.: Spiking neuron models. Cambridge University Press, Cambridge (2002)
[12] The networks have been simulated using the Csim Toolbox available at http://www.lsm.tugraz.at/csim The parameters of the LIF neurons are: Rm=1M╬®, ¤äm=20ms, Vthresh=-0.045V, Vresting=-0.06V, Vreset=- 0.06V, Vinit=-0.06V, Trefract=1ms. The parameters of the synapses are ¤äContra=2ms, ¤äIpsi=0.5ms, Wmax=1e-4. The parameters of the windows are A+=2/3, B+=0.25, ╬À+=50e-6, ¤ä+ 0 =1/10ms, ¤ä+ 1 =1/200ms, ¤ä+ 2 =1/2ms, s*+=-1/800ms, A−=0.7, B−=0.25, ╬À−=50e-6, ¤ä−0 =1/5ms, ¤ä−1 =1/20ms, ¤ä−2 =1/2ms, s*−=-0.1ms.