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Physical and Chemical Investigation of Polycaprolactone, Nanohydroxyapatite and Poly (Vinyl Alcohol) Nanocomposite Scaffolds

Authors: A.Doustgani, E.Vasheghani- Farahani, M. Soleimani, S. Hashemi-Najafabadi


Aligned and random nanofibrous scaffolds of PVA/PCL/nHA were fabricated by electrospinning method. The composite nanofibrous scaffolds were subjected to detailed analysis. Morphological investigations revealed that the prepared nanofibers have uniform morphology and the average fiber diameters of aligned and random scaffolds were 135.5 and 290 nm, respectively. The obtained scaffolds have a porous structure with porosity of 88 and 76% for random and aligned nanofibers, respectively. Furthermore, FTIR analysis demonstrated that there were strong intramolecular interactions between the molecules of PVA/PCL/nHA. On the other hand, mechanical characterizations show that aligning the nanofibers, could significantly improve the rigidity of the resultant biocomposite nanofibrous scaffolds.

Keywords: polycaprolactone, poly (vinyl alcohol), Electrospinnig, nanofibrous scaffold

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[1] A.L.Yarin, S. Koombhongse, D.H. Reneker, "Bending instability in electrospinning of nanofibers," J. Appl. Phys., vol. 89, pp. 3018-3026, 2001.
[2] E. Adomaviciute, R. Milasius, "The influence of applied voltage on poly (vinyl alcohol) (PVA) nanofibre diameter," Fibers. Text. East. Eur., vol. 15, pp. 64-65, 2007.
[3] Y.K. Luu, K. Kim, B.S. Hsiao, B. Chu, M. Hadjiargyrou, "Development of a nanostructured DNA delivery scaffold via electrospinning of PLGA and PLA-PEG block copolymers, " J. Control. Release, vol. 89, pp. 341-353, 2003.
[4] T. Subbiah, G.S. Bhat, R.W. Tock, S. Parameswaran, S.S. Ramkumar, "Electrospinning of nanofibers," J. Appl. Polym. Sci., vol. 96, pp. 557-569, 2005.
[5] S. Ramakrishna, K. Fujihara, W.E. Teo, T. Yong, Z. Ma, R. Ramaseshan, "Electrospun nanofibers: solving global issues," Mater. Today, vol. 9, pp. 40-50, 2006.
[6] W. Cui, S. Zhou, X. Li, J. Weng, "Drug-loaded biodegradable polymeric nanofibers prepared by electrospinning," Tissue. Eng., vol. 12, pp. 1070, 2006.
[7] Y. Wu, J.H. He, L. Xu, J.Y. Yu, "Electrospinning drug-loaded poly (Butylenes Succinate-cobytylene Terephthalate) (PBST) with acetylsalicylic acid (aspirin)," Int. J. Electrospun. Nanofibers. Appl., vol. 1, pp. 1-6, 2007.
[8] A. Welle, M. Kroger, M. Doring, K. Niederer, E. Pindel, S. Chronakis, "Electrospun aliphatic polycarbonates as tailored tissue scaffold materials," Biomaterials, vol. 28, pp. 2211-2219, 2007.
[9] C.P. Barnes, S.A. Sell, D.C. Knapp, B.H. Walpoth, D.D. Brand, G.L. Bowlin, "Preliminary investigation of electrospun collagen and polydioxanone for vascular tissue engineering applications," Int. J. Electrospun. Nanofibers. Appl., vol. 1, pp. 73-87, 2007.
[10] J.A. Matthews, G.E. Wnek, D.G. Simpson, G.L. Bowlin, "Electrospinning of Collagen Nanofibers," Biomacromolecules, vol. 3, pp. 232-238, 2002.
[11] A. Theron, E. Zussman, A.L. Yarin, "Electrostatic field-assisted alignment of electrospun nanofibers," Nanotechnology, vol. 12, pp. 384-390, 2001.
[12] D. Li, Y. Wang, Y. Xia, "Multiple-Walled Nanotubes Made of Metals, " Adv. Mater. Vol. 16, pp. 361-366, 2004.
[13] V. Thomas, D.R. Dean, M.V. Jose, B. Mathew, S. Chowdhury, Y.K. Vohra, "Nanostructured biocomposite caffolds based on collagen coelectrospun with nanohydroxyapatite", Biomacromolecules, vol. 8(2), pp. 631-637, 2007.
[14] C.D. Kesel, C. Lefevre, B. Nagy, C. David, "Blends of polycaprolactone with polyvinyl alcohol: a DSC, optical microscopy and solid state NMR study", Polymer, vol. 40, pp. 1969-1978, 1999.
[15] M.V. Jose, V. Thomas, K.T. Johnson, D.R. Dean, E. Nyairo, "Aligned PLGA/HA nanofibrous nanocomposite scaffolds for bone tissue engineering", Acta. Biomater., vol. 5, pp. 305-312, 2009.
[16] Z. Yin, X. Chen, J.L. Chen, W.L. Shen, T.M.H. Nguyen, L. Gao, H.W. Ouyang, " The regulation of tendon stem cell differentiation by the alignment of nanofibers ", Biomaterials, vol. 31, pp. 2163-2175, 2010.