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Study on Antioxidant and Antitumor Activities of Some Herbal Extracts

Authors: S.S. Maw, M. M. Mon, Z .K .Oo


The potential of antioxidant activities of the plant extract Gynura procumbens, Achyranthes aspera and Polygenum tomentosum were studied by using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) .Antioxidant activity was qualitatively and quantitatively determined. In this analysis , Ascorbic acid (Vitamin C) was used as the standard .The antioxidant activities were observed all three plant extracts and the EC50 values of G procumbens A.aspera and P.tomemtosum were 13.7 μg /ml,14.37 μg /ml and 14.35 μg /ml. Among these plants, G.procumbens is more potent antioxidant activity then others. Antitumor activities were found with A.aspera (s2) extracts in the dose of 100ppm in carrot disks and G.procumbens (s1) and P.tomentosum (s3) in the dose of 1000 ppm. Therefore, these herbal plants are used in traditional medicines.

Keywords: antioxidant activity, DPPH, antitumor activity, G.procumbens

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[1] Burkill, I. H. "A Dictionary of the Economic Product of Malay Peninsular. Kuala Lumpur;" Ministry of Agriculture and Co-operatives, Kuala Lumpur, Vol. 1 and 11, p2444, 1966W.-K. Chen, Linear Networks and Systems (Book style). Belmont, CA: Wadsworth, 1993, pp. 123-135.
[2] S. Z. Hoe, S. K. Lam, & L. T. Ng, "Hot water extraction releases unknown bradycardiac compounds from Gynura procumbens," in the 16th Scientifc Meeting of Malaysian Society of Pharmacology and Physiology, 25-26 June, Kuala Lumpur, University MalayaB,2001.
[3] W. Jiratchariyakul, Jarikasem, S. Siritantikorn, A. Somanabandhu, & A. W. Frahm, Antiherpes Simplex Viral compounds from Gynura procumbens, Merr. Mahidol University Annual Research Abstracts, 2001, 28, No 498..
[4] Nuchanart Rangkadilok,ÔÇá Luksamee Worasuttayangkurn,ÔÇá Richard N. Bennett,ÔÇí and Jutamaad Satayavivad*ÔÇá┬º, "Identification and Quantification of Polyphenolic Compounds in Longan (Euphoria longana Lam.) Fruit", J. Agric. Food Chem., 2005, 53 (5), pp 1387- 1392.
[5] Singh, S. B., Graham, P. L., Reamer, R. A., and Cordingley, M. G. 2001. Discovery, total synthesis, HRV 3C-protease inhibitory activity, and structure-activity relationships of 2-methoxystypandrone and its analogues. Bioorg. Med. Chem. Lett., 11, 143.
[6] Takasaki, M., Konoshima, T., Kuroki S., Tokuda, H., and Nishino, H. 2001. Cancer chemopreventive activity of phenylpropanoid esters of sucrose, vanicoside B and lapathoside A, from Polygonum lapathifolium. Cancer Lett., 173, 133.
[7] Tsai, P. L., Wang, J. P., Chang, C. W., Kuo, S. C., and Chao, V. 1998. Constituents and bioactive principles of Polygonum chinensis. Phytochemistry, 49, 1663.
[8] Urones, J. G., Marcos, I. S., Pérez, B. G., and Barcala, P. B. 1990. Flavonoids from Polygonum minus. Phytochemistry, 29, 3687
[9] N. Ramesh., M. B. Viswanathan., A. Saraswathy., K. Balakrishna., P. L. Brindha, "Phytochemical and antimicrobial studies of Begonia malabarica", J Ethonopharmacol , 2002, 79:129-32.S. P. Bingulac, "On the compatibility of adaptive controllers (Published Conference Proceedings style)," in Proc. 4th Annu. Allerton Conf. Circuits and Systems Theory, New York, 1994, pp. 8-16.
[10] A. Rojas., L. Hernandez., R. Pereda-Miranda., R. Mata, "Screening for antimicrobial activity of crude drug extracts and pure natural products from Mexican medicinal plants," J Ethonopharmacol, 1992; 35: 275 -83.
[11] D. Bandoniene., M. Murkovic; W. Pfannhauser., P. R. Venskutonis., D. Gruzdiene, "Detection and activity evaluation of radical scavengingcompounds by using DPPH free radical and on-line HPLCDPPH methods", Eur. Food Res. Technol., 2002; 214, 143-147.
[12] K. Marxen., K. H. Vanselow., S. Lippemeier., R. Hintze., A. Ruser, and U. P. Hansen., "Determination of DPPH Radical Oxidation Caused by Methanolic Extracts of Some Microalgal Species by Linear Regression Analysis of Spectrophotometric Measurements", ISSN1424-8220, 2007.
[13] R. Govindarajan., S. Rastogi., M. Vijayakumar., A. K. S. Rawat, A., Shirwaikar., S. Mehrotra. and P. Pushpangadan,., "Studies on antioxidant activities of Desmodium gangeticum", Biol. Pharm. Bull. 26, 2003, 1424-1427.
[14] Galsky AB, Wilsey JP, Powell RG, " Crown-gall tumor disc bioassay: a possible aid in the detection of compounds with antitumor activity". Plant Physiol 65: 184Ð185, 1980.
[15] Ahsan HUSSAIN, Muhammad ZIA, Bushra MIRZA, " Cytotoxic and Antitumor Potential of Fagonia cretica L." Department of Biochemistry, Faculty of Biological Science, Quaid-i-Azam University, Islamabad - Pakistan.