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Hydrogels Based on Carrageenan Extracted from Kappaphycus alvarezii

Authors: S. Distantina, Rochmadi, M. Fahrurrozi, Wiratni


Preparation of hydrogel based on carrageenan extracted from Kappaphycus alvarezii was conducted with film immersion in glutaraldehyde solution (GA 4%w/w) for 2min and then followed by thermal curing at 110°C for 25min. The method of carrageenan recovery strongly determines the properties of crosslinked carrageenan. Hydrogel obtained from alkali treated carrageenan showed higher swelling ability compared to hydrogel from nonalkali treated carrageenan. Hydrogel from alkali treated showed the ability of sensitive to pH media.

Keywords: Hydrogel, carrageenan, swelling, alkali treated.

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[1] V.L. Campo, F.F. Kawano, D.B. Silva Junior, and I. Carvalho, "Carrageenans: biological properties, chemical modifications and structural analysis", Carbohyd. Polym., 77, pp. 167-180, 2009.
[2] S. Keppeler, A. Ellis, and J.C. Jacquier, "Cross-linked carrageenan beads for controlled release delivery systems", Carbohyd. Polym., 78, pp. 973- 977, 2009.
[3] V. Pascalau, V. Popescu, G.L. Popescu, M.C. Dudescu, G. Borodi, A. Dinescu, I. Perhaita, and M. Paul, 2012, " The alginate/k-carrageenan ratio-s influence on the properties of the cross-linked composite films", J. Alloys Compd., 536, pp. S418-S434, 2012.
[4] R. Meena, K. Prasad ,and A.K. Siddhanta, "Effect of genipin, a naturally occuring crosslinker on the properties of kappa-carrageenan", Int. J. Biol. Macromol., 41,pp. 94-101, 2007.
[5] P.L.R. Cunha, R.R. Castro, F.A.C. Rocha, R.C.M. de Paula, and J.P.A. Feitosa, "Low viscosity hydrogel of guar gum: Preparation and physicochemical characterization", Int. J. Biol. Macromol., 37, pp. 99- 104, 2005.
[6] M. George and T.E. Abraham, "pH sensitive alginate-guar gum hydrogel for controlled delivery of protein drugs", Int. J. Pharm., 335, pp. 123- 129, 2007.
[7] J. Shang, Z. Shao, and X. Chen, "Chitosan-based electroactive hydrogel", Polym., 49, pp.5520-5525, 2008.
[8] D.M. Verissimo, R.F.C. Leitao, R..A Ribeiro, S.D. Figueiro, A.S.B. Sombra, J.C. Goes, and G.A.C. Brito, "Polyanionic collagen membranes for guided tissue regeneration: Effect of progressive glutaraldehyde cross-linking on biocompatibility and degradation", Acta Biomater., 6, pp. 4011-4018, 2010.
[9] R.I. Montolalu, Y. Tashiro, S. Matsukawa, and H. Ogawa, "Effect of Extraction Parameters on Gel Properties of Carrageenan from Kappaphycus alvarezii (Rhodophyta)", J. Of App. Phycology, 20, pp. 521-526, 2007.
[10] L. Hilliou, F.D.S. Larotonda, P. Abreu, A.M. Ramos , A.M. Sereno, and M.P. Gonc┬©alves., 2006, "Effect of extraction parameters on the chemical structure and gel properties of k/i-hybrid carrageenans obtained from Mastocarpus stellatus", Biomol. Eng., 23, pp. 201-208, 2006.
[11] D.A. Navarro and C.A. Stortz, "Microwave-assisted alkaline modification of red seaweed galactans", Carbohyd. Polym., 62 , pp. 187-191, 2005.
[12] S. Distantina, Wiratni, M. Fahrurrozi, and Rochmadi, "Carrageenan properties extracted from Eucheuma cottonii, Indonesia", World Academy of Science, Engineering and Technology, 78, 738-742, 2011.
[13] G.H. Jeffery, J. Bassett, J., Mendham, J. dan Denney, R.C. Vogel-s Textbook of Quantitative Chemical Analysis, 5th ed., Bath press, Avon, Great Britain, 1989, pp.490-493.
[14] R. Falshaw,R.H. Furneaux, and D.E. Stevenson, "Agars from nine speciaes of red seaweed in the genus curdie (glacilariaceae, rhodophyta)", Carbohyd. Res., 308, pp.107-115, 1998.
[15] F. Van de Velde, S.H. Knutsen, A.I. Usov, H.S. Rollema, and A.S. Cerezo, "1H and 13C High resolution NMR spectroscopy of carrageenans: aplication in research and industry", Trend Food Sci. Tech., 13, pp.73-92, 2002.
[16] Ciancia, M., Noseda, M.D., Matulewicz, M.C., and Cerezo, A.S., 1993, "Alkali-modification of carrageenans: Mechanism and Kinetics in the kappa/iota-, mu/nu- and lambda-series", Carbohyd. Polym., 20, pp.95- 98, 1993
[17] R. Falshaw, H.J. Bixler, and K. Johndro, "Structure and Performance of Commercial kappa-2 Carrageenan Extracts", Food Hydrocoll., 15, pp.441-451, 2001.
[18] Y. Qiu, and K. Park, "Environment-sensitive hydrogels for drug delivery", Advanced Drug Delivery Reviews, 53, pp.321-339, 2001.