Commenced in January 2007
Paper Count: 30172
A Stochastic Approach of Mitochondrial Dynamics
Abstract:Mitochondria are dynamic organelles, capable to interact with each other. While the number of mitochondria in a cell varies, their quality and functionality depends on the operation of fusion, fission, motility and mitophagy. Nowadays, several researches declare as an important factor in neurogenerative diseases the disruptions in the regulation of mitochondrial dynamics. In this paper a stochastic model in BioAmbients calculus is presented, concerning mitochondrial fusion and its distribution in the renewal of mitochondrial population in a cell. This model describes the successive and dependent stages of protein synthesis, protein-s activation and merging of two independent mitochondria.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1082774Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1139
 D.C. Chan, "Mitochondrial fusion and fission in mammals," Ann. Rev. Cell Dev. Biol.,vol. 22, pp. 79-99, 2006.
 G. Twig et al., "Fission and selective fusion govern mitochondrial segregation and elimination by autophagy," EMBO J., vol. 27, pp. 433- 446, 2008.
 D.F. Suen, K.L. Norris and R.J. Youle, "Mitochondrial dynamics and apoptosis," Genes Dev., vol.22, pp. 1577-1590, 2008.
 H. Chen and D.C. Chan, "Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases," Human Molecular Genetics, vol. 18, pp. 169-176, 2009.
 T. Kanki and D.J. Klionsky, "Mitophagy in yeast occurs through a selective mechanism," J. Biol. Chem., vol. 283, pp. 32386-32393, 2008.
 P. Verstreken et al., "Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions," Neuron, vol. 47, pp. 365-378, 2005.
 Z. Li, K. Okamoto, Y. Hayashi and M. Sheng, "The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses," Cell, vol. 119, pp. 873-887, 2004.
 K. Hirai et al., "Mitochondrial abnormalities in Alzheimer-s disease" The Journal of Neuroscience, vol. 21, pp. 3017-3023, 2001.
 R.H. Swerdlow and S.M. Khan, "A "mitochondrial cascade hypothesis" for sporadic Alzheimer's disease," Med Hypotheses, vol. 63, pp. 8-20, 2004
 R.H. Swerdlow and S.M. Khan, "The Alzheimer's disease mitochondrial cascade hypothesis: an update," Exp Neurol., vol. 218, pp. 308-315, 2009.
 X. Wang et al., "Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins," Proc. Natl. Acad. Sci., vol. 105, pp. 19318- 19323, 2008.
 I.G. Onyango et al., "Regulation of neuron mitochondrial biogenesis and relevance to brain health", Biochimica et Biophysica Acta, vol. 1802, pp.228-234, 2010.
 A. Alexiou, P. Vlamos and K. Volikas, "A Theoretical Artificial Approach on Reducing Mitochondrial Abnormalities in Alzheimer-s Disease," in 10th IEEE Int. Conf. 2010 on Information Technology and Applications in Biomedicine.
 S.A. Detmer and D.C. Chan, "Functions and dysfunctions of mitochondrial dynamics," Nat. Rev. Mol. Cell Biol., vol. 8, pp. 870-879, 2007.
 S. Meeusen et al., "Mitochondrial inner-membrane fusion and crista maintenance requires the dynamin-related GTPase Mgm1," Cell, vol. 127, pp. 383-395, 2006
 Z. Song, M, Ghochani, J.M. McCaffery, T.G. Frey and D.C. Chan, "Mitofusins and OPA1 Mediate Sequential Steps in Mitochondrial Membrane Fusion," Mol. Biol. Cell., vol. 20, pp. 3525-3532, 2009.
 S. Gandre-Babbe and A.M. van der Bliek, "The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells," Mol. Biol. Cell, vol. 19, pp. 2402-2412, 2008.
 K. Okamoto and J.M. Shaw, "Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes," Annu. Rev. Genet., vol. 39, pp. 503-536, 2005.
 A. Regev, E.M. Panina, W. Silverman, L. Cardelli and E.Y. Shapiro, "Bioambients: an abstraction for biological compartments," Theor. Comput. Sci., vol. 325, pp. 141-167, 2004.