Commenced in January 2007
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Ultrasonic System for Diagnosis of Functional Gastrointestinal Disorders: Development, Verification and Clinical Trials
Abstract:Functional gastrointestinal disorders affect millions of people spread all age regardless of race and sex. There are, however, rare diagnostic methods for the functional gastrointestinal disorders because functional disorders show no evidence of organic and physical causes. Our research group identified recently that the gastrointestinal tract well in the patients with the functional gastrointestinal disorders becomes more rigid than healthy people when palpating the abdominal regions overlaying the gastrointestinal tract. Aim of this study is, therefore, to develop a diagnostic system for the functional gastrointestinal disorders based on ultrasound technique, which can quantify the characteristic above related to the rigidity of the gastrointestinal tract well. Ultrasound system was designed. The system consisted of transmitter, ultrasonic transducer, receiver, TGC, and CPLD, and verified via a phantom test. For the phantom test, ten soft-tissue specimens were harvested from porcine. Five of them were then treated chemically to mimic a rigid condition of gastrointestinal tract well, which was induced by functional gastrointestinal disorders. Additionally, the specimens were tested mechanically to identify if the mimic was reasonable. The customized ultrasound system was finally verified through application to human subjects with/without functional gastrointestinal disorders (Normal and Patient Groups). It was identified from the mechanical test that the chemically treated specimens were more rigid than normal specimen. This finding was favorably compared with the result obtained from the phantom test. The phantom test also showed that ultrasound system well described the specimen geometric characteristics and detected an alteration in the specimens. The maximum amplitude of the ultrasonic reflective signal in the rigid specimens (0.2±0.1Vp-p) at the interface between the fat and muscle layers was explicitly higher than that in the normal specimens (0.1±0.0Vp-p). Clinical tests using our customized ultrasound system for human subject showed that the maximum amplitudes of the ultrasonic reflective signals near to the gastrointestinal tract well for the patient group (2.6±0.3Vp-p) were generally higher than those in normal group (0.1±0.2Vp-p). Here, maximum reflective signals was appeared at 20mm depth approximately from abdominal skin for all human subjects, corresponding to the location of the boundary layer close to gastrointestinal tract well. These results suggest that newly designed diagnostic system based on ultrasound technique may diagnose enough the functional gastrointestinal disorders.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1081707Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF
 International Foundation for Functional Gastointestinal Disorders. "Gastointestinal functional and motility disorders". Available: http://www.iffgd.org/GIDisoders/Glmain.html 2006.
 N. J. Talley, V. Stanghellini, R. C. Heading, K. L. Koch, J. R. Malagelada, and G. N. Tytgat. "Functional gastrointestinal disorders". Gut, 45:1137-1142, 1999. Patient Group Amplitude (Voltage) Boundary of the gastrointestinal tract well Time (second) Interface between the skin and fat layers Normal Group Amplitude (Voltage) Time (second) Interface between the skin and fat layers Boundary of the gastrointestinal tract well
 W. G. Thompson, G. F. Longstreth, D. A. Drossman, K. W. Heaton, E. J. Irvine, and S. A. Muller-Lissner. "Functional bowel disorders and functional abdominal pain". Gut, 45:1143-1147, 1999.
 C. Rubin, M. Bolander, J. Ryaby, and M. Hadjiargyrou. "The use of low-intensity ultrasound to accelerate the healing of fractures". J. Bone Joint Surg., 83A:259-270, 2001.
 R. St John Brown. "How safe is diagnostic ultrasonography". J Can Med Assoc, 131:307-311, 1984.
 T. Szabo. "Diagnostic Ultrasound Imaging: Inside Out ". Elsevier Inc., London, 2004.
 K. W. Min and M. Leabu. "Interstitial Cells of Cajal (ICC) and Gastrointestinal Stromal Tumor (GIST): facts, speculations, and myths." J. Cell Mol Med. , 10:995-1013, 2006.
 M. Takaki. "Cut pacemaker cells: the interstitial cells of cajal (ICC)". J. Smooth Muscle Res., 39:137-161, 2003.
 K. D. Keef, D. C. Murray, K. M. Sanders, and T. K. Smith. "Basal release of nitric oxide induces an oscillatory motor pattern in canine colon". J. Physiol., 499:773-786, 1997.
 T. K. Smith, J. B. Reed, and K. M. Sanders. "Interaction of two electrical pacemakers in the muscularis of the canine proximal colon". Am. J. Physiol., 252:C290-C299, 1987.
 A. C. Guyton and J. E. Hall. "Textbook of medical physiology". 10 ed. W.B. Saunders, Philadelphia, 2000.