Commenced in January 2007
Paper Count: 30998
Optimizing Voltage Parameter of Deep Brain Stimulation for Parkinsonian Patients by Modeling
Abstract:Deep Brain Stimulation or DBS is the second solution for Parkinson's Disease. Its three parameters are: frequency, pulse width and voltage. They must be optimized to achieve successful treatment. Nowadays it is done clinically by neurologists and there is not certain numerical method to detect them. The aim of this research is to introduce simulation and modeling of Parkinson's Disease treatment as a computational procedure to select optimum voltage. We recorded finger tremor signals of some Parkinsonian patients under DBS treatment at constant frequency and pulse width but variable voltages; then, we adapted a new model to fit these data. The optimum voltages obtained by data fitting results were the same as neurologists- commented voltages, which means modeling can be used as an engineering method to select optimum stimulation voltages.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1334864Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1368
 H. Yu, J. S. Neimat, "The Treatment of Movement Disorders by Deep Brain Stimulation", Vol. 5, 26-36, January 2008 ┬® The American Society for Experimental NeuroTherapeutics, Inc.
 D. S. Kern, R. Kumar, "Deep Brain Stimulation", The Neurologist ÔÇó Volume 13, Number 5, September 2007.
 R. Edwards, A. Beuter, "Parkinsonian Tremor and Simplification in Network Dynamics" Bulletin of Mathematical Biology (1999)51, 157_177 Article No. bulm 1998.0086
 A. H. V. Schapira, E. Bezard, J. Brotchie, F. Calon, G. L. Collingridge, B. Ferger, B. Hengerer, E. Hirsch, P. Jenner, N. Le Novere, J. A. Obeso, M. A. Schwarzschild, U. Spampinate and G. Davidai."Novel Pharmacological Targets the Treatment of Parkinson-s Disease" NATURE REVIEWS DRUG DISCOVERY, VOLUME 5, Oct 2006, 845
 J. L. Alberts, M.S. Vitek, " The Persistent Effects of Unilateral Pallidal and Subthalamic Deep Brain Stimulation on Force Control in Advanced Parkinson-s Patients"
 M. Haeri, Y. Sarbaz, Sh. Gharibzadeh, "Modeling the Parkinson-s tremor and its treatments", Journal of Theoretical Biology 236, 311- 322, 2005.
 P. Limousin, I. Martinez-Torres, "Deep Brain Stimulation for Parkinson-s Disease" Vol. 5, 309-319, April 2008, the American Society for Experimental NeuroTherapeutics,Inc.
 A. Antonini, "New Strategies in Motor Parkinsonism" 2007 Elsevier
 X. J. Feng, B. Greenwald, H. Rabitz, E. S. Brrown and R. Kosut. " ToWard Closed-Loop Optimization of Deep Brain Stimulation for Parkinson-s Disease: Concepts and Lessons from a Computational Modeling" Appears in J. Neuroengineering 4 (2007) L14-L21
 T. Fiegele, G. Feuchtner, F. Sohm, R. Bauer, J. V. Anton, T. Gotwald and et al "Accuracy of stereotactic electrode placement in deep brain stimulation by intraoperative computed tomography"., Department of Neurosurgery, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria b Department of Radiology II, Innsbruck Medical University, Innsbruck, Austria Received 16 August 2007; received in revised form 13 November 2007; accepted 3 January 2008
 A. M. Kuncel, W. M. Grill, "Selection of stimulus parameters for deep brain stimulation", Clinical Neurophysiology 115 (2004) 2431-2441
 Erwin B. Montgomery Jra,_, John T. Galeb "Mechanisms of action of deep brain stimulation (DBS)" Department of Neurology, National Primate Research Center, University of Wisconsin-Madison, H6/538 CSC, 600 Highland Ave., Madison, WI 53792, USA Department of Neurosurgery, Massachusetts General Hospital/Harvard Medical School, Edwards Research Building, EDR 410, 50 Blossom St., Boston, MA 02114, USA
 M.S. Titcombe, L. Glass, A. Beuter , "Dynamics of Parkinsonian tremor during deep brain stimulation", American Institute of Physics, DECEMBER 2001.
 T. O. Videen, M. C. Campbell , S. D. Tabbal, M. Karimi, T. Hershey, J. S. Perlmutter, "Validation of a fiducial-based atlas localization method for deep brain stimulation contacts in the area of the subthalamic nucleus", Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA Department of Anatomy & Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO 63110, USA Received 7 June 2007; received in revised form 11 October 2007; accepted 11 October 2007
 B. Blad, L. Bertenstam, S. Rehncrona, H. Bjartmarz, A.-L. Törnqvist, "Measurement of contact impedance of electrodes used for deep brain stimulation", ITBM-RBM 26 (2005) 344-346.