Viscoelastic Modeling of Brain MRE Data Using FE Method
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Viscoelastic Modeling of Brain MRE Data Using FE Method

Authors: H. Ajabi Naeeni, M. Haghpanahi


Dynamic shear test on simulated phantom can be used to validate magnetic resonance elastography (MRE) measurements. Phantom gel has been usually utilized for the cell culture of cartilage and soft tissue and also been used for mechanical property characterization using imaging systems. The viscoelastic property of the phantom would be important for dynamic experiments and analyses. In this study, An axisymmetric FE model is presented for determining the dynamic shear behaviour of brain simulated phantom using ABAQUS. The main objective of this study was to investigate the effect of excitation frequencies and boundary conditions on shear modulus and shear viscosity in viscoelastic media.

Keywords: Viscoelastic, MR Elastography, Finite Element, Brain.

Digital Object Identifier (DOI):

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[1] Basford, J.R., Jenkyn, T.R., An, K.N., Ehman, R.L., Heers, G., Kaufman, K.R., 2002. Evaluation of healthy and diseased muscle with magnetic resonance elastography. Archives of Physical Medicine and Rehabilitation 83, 1530-1536.
[2] Beards C.E. Structural Vibration: Analysis and Damping. Butterworth- Heinemann, 1996.
[3] Bishop J, Poole G, Leitch M, Plewes DB. Magnetic resonance imaging of shear wave propagation in excised tissue. J Magn Reson Imaging 1998; 8:1257- 65.
[4] Brands DWA, Bovendeerd PHM, Peters GWM, Paas M, van Bree J,Wismans JSHM (1999) Comparison of the dynamic behaviour of brain tissue and two model materials. Stapp Car Crash Conference Journal, 1999, Paper no. 99sc21, 5764
[5] Chen Q., Ringleb S.I., Manduca A., Ehman R.L., An K.N. A finite element model for analyzing shear wave propagation observed in magnetic resonance elastography, Journal of Biomechanics: 2198-2203, 2005.
[6] Darvish, K.K. and Crandall, J.R., (2001). ÔÇÿNonlinear viscoelastic effects in oscillatory shear deformation of brain tissue.- Medical engineering and Physics, 23(9), 633-645.
[7] Dresner, A.M., Rose, G.H., Rossman, P.J., Muthupillai, R.,Manduca, A., Ehman, R.L., 2001. Magnetic resonance elastography of skeletal muscle. Journal of Magnetic Resonance Imaging 13,269-276.
[8] Green M, Sinkus R, Cheng S, Bilston L. 3D MR-elastography of the brain at 3 tesla. Proceedings of the International Society of Magnetic Resonanc Medicine 13. 2005; 2176.
[9] Hamhaber U, Sack I, Papazoglou S, Rump J, Klatt D, Braun J. Threedimensional analysis of shear wave propagation observed by in vivo magnetic resonance elastography of the brain. Acta Biomater. 2007; 3(1): 127-137.
[10] Klatt D., Hamhaber U., Asbach P., Braun J., Sack I. 2007 .Noninvasive assessment of the rheological behavior of human organs using multifrequency MR elastography: a study of brain and liver viscoelasticity. Phys. Med. Biol. 52 7281-7294
[11] Kruse, S.A., Smith, J.A., Lawrence, A.J., Dresner, M.A., Manduca, A., Greenleaf, J.F., Ehman, R.L., 2000. Tissue characterization using magnetic resonance elastography: preliminary results. Physics in Medicine and Biology 45, 1579-1590.
[12] Manduca A., Oliphant T.E., Dresner M.A., Mahowald J.L., Kruse S.A., Amromin E., Felmlee J.P., Greenleaf J.F., Ehman R.L. Magnetic resonance elastography: non-invasive mapping of tissue elasticity. Medical Image Analysis 5, 237-254. 2001.
[13] Muthupillai R, Lomas DJ, Rossman PJ, Greenleaf JF, Manduca A, Ehman RL. Magnetic resonance elastography by direct visualization of propagating acoustic strain waves. Science 1995;269:1854 -7.
[14] Prange, M.T., Meaney, D.F. and Margulies, S.S., (2000). ÔÇÿDefining Brain Mechanical Properties: Effects of Region, Direction and Species.- StappCar Crash Journal, 44, 205-214.
[15] Peters, G., Meulman, H. and Sauren, A., (1997). ÔÇÿApplication of the Time Temperature Superposition Theory on Brain Tissue.- Biorheology, 34, 127-138.
[16] Sack I, Beierbach B, Hamhaber U, Klatt D and, Braun U. Non-invasive measurement of brain viscoelasticity using magnetic resonance elastography. NMR In Biomedicine, 2007, In press.
[17] Sack, I., Bernarding, J., Braun, J., 2002. Analysis of wave patterns in MR elastography of skeletal muscle using coupled harmonic oscillator simulations. Magnetic Resonance Imaging 20, 95-104.
[18] Sarvazyan AP, Rudenko OV, Swanson SD, Fowlkes JB, Emelianov SY. Shear wave elasticity imaging: a new ultrasonic technology of medical diagnostics. Ultrasound Med Biol 24 (9):1419-1435, 1998.
[19] Sinkus R., Tanter M., Xydeas T., Catheline S., Bercoff J., Fink M. Viscoelastic shear properties of in vivo breast lesions measured by MR elastography. Magnetic Resonance Imaging 23: 159-165, 2005.
[20] Uffmann K, Maderwald S, de Greiff A, Ladd M. Determination of gray and white matter elasticity with MR elastography. Proceedings of the International Society of Magnetic Resonanc Medicine 12. 2004; 1768.
[21] Van Houten E.E.W., Weaver J.B., Miga M.I., Kennedy F.E., Paulsen K.D. Elasticity reconstruction from experimental MR displacement data: initial experience with an overlapping subzone finite element inversion process. Medical Physics 27, 101-107,2000.
[22] Vappou J., Breton E., Choquet P., Goetz C., Willinger R., Constantinesco A. Magnetic resonance elastography compared with rotational rheometry for in vitro brain tissue viscoelasticity measurement. Magn Reson Mater Phy (2007) 20:273-278
[23] Yamakoshi Y, Sato J, Sato T. Ultrasonic imaging of internal vibration of soft tissue under forced vibration. IEEE Trans Ultrason Ferroelectr Freq Control 37 (2):45-53, 1990.