ME/CFS Health Outcomes: The Interaction of Mode of Illness Onset and Psychiatric Comorbidity

Authors: Mary Gloria C. Njoku, Leonard A. Jason, Nicole Porter, Molly Brown

Abstract:

The objective of this study was to examine the interaction between mode of illness onset and psychiatric comorbidity on the health outcomes of persons with ME/CFS. A total of 114 individuals with ME/CFS participated in this study. Individuals completed a battery of baseline measures including the fatigue severity scale and measures of disability. Findings indicated that those with sudden illness onset had more impaired physical health functioning. In addition, among individuals with sudden onset, those without psychiatric comorbidity had greater fatigue severity and lower overall physical health than those with psychiatric comordibity. In contrast, among individuals with gradual illness onset, those with psychiatric comorbity had higher fatigue severity than those without comorbid psychiatric disorders. The health outcomes of individuals who have ME/CFS with or without psychiatric comorbidity are impacted by the mode of illness onset and this suggest that it is important to examine these factors in future research.

Keywords: Health Outcomes, ME/CFS, Mode of Illness Onset, Psychiatric Comorbidity.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1079978

References:

[1] Fukuda K, Strauss SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A. The chronic fatigue syndrome: A comprehensive approach to its definition and study. Annals of Internal Medicine 1994;121:953-9.
[2] Jason LA, Richman JA, Rademaker AW, Jordan KM, Plioplys AV, Taylor RR, McCready W, Huang C-F, Plioplys S. A community-based study of chronic fatigue syndrome. Archives of Internal Medicine 1999;159:2129-37.
[3] Claypoole KH, Noonan C, Mahurin RK, Goldberg J, Erickson T, Buchwald D. A twin study of cognitive function in chronic fatigue syndrome: The effects of sudden illness onset. Neuropsychology 2007; 21:507-13.
[4]. Friedberg F, Jason LA. Understanding chronic fatigue syndrome: An empirical guide to assessment and treatment. Washington, DC, US: American Psychological Association; 1998.
[5] Jason LA, Taylor RR, Kennedy CL, Song S, Johnson D, Torres S. Chronic fatigue syndrome: Occupation, medical utilization, and subtypes in a community-based sample. Journal of Nervous and Mental Disease 2000; 188:568-76.
[6] Reyes M, Dobbins JG, Nisenbaum R, Subedar NS, Randall B, Reeves WC. CFS progression and self-defined recovery: Evidence from the CDC surveillance system. Journal of Chronic Fatigue Syndrome 1999; 5:17-27.
[7] Schwartz R, Komaroff A, Garada B, Gleit M, Doolittle T, Bates D, Vasile R, Holman B. SPECT imaging of the brain: comparison of findings in patients with chronic fatigue syndrome, AIDS dementia complex, and major unipolar depression. American Journal of radiology 1994; 162:943-51.
[8] Levine PH. Epidemiologic advances in chronic fatigue syndrome Journal of Psychiatric Research 1997; 31:7-18.
[9] DeLuca J, Johnson SK, Ellis SP, Natelson BH. Sudden vs gradual onset of chronic fatigue syndrome differentiates individuals on cognitive and psychiatric measures. Journal of Psychiatric Research 1997; 31:83-90.
[10] Salit IE. Precipitating factors for the chronic fatigue syndrome Journal of Psychiatric Research; 31:59-65.
[11] Holmes GP KJ, Gantz NM, Komaroff AL, Schonberger LB, Straus SE, Jones JF, Dubois RE, Cunningham-Rundles C, Pahwa S, Tosato G, Zegans LS, Purtilo DT, Browh N, Schooles RT, Brus I. Chronic fatigue syndrome: a working case definition. Annals of Internal Medicine 1988;108:387-9.
[12] Taylor RR, Jason LA, Curie CJ. Prognosis of chronic fatigue in a community-based sample. Psychosomatic Medicine 2002; 64:319-27.
[13] Jason LA, Taylor RR, Kennedy CL, Jordan KM, Song S, Johnson D, Torres-Harding S. Chronic fatigue syndrome: Symptom subtypes in a community based sample. Women & Health 2003; 37:1-13.
[14] Njoku MGC, Jason LA, Torres-Harding SR. The prevalence of chronic fatigue syndrome in Nigeria. Journal of Health Psychology 2007;12:461-74.
[15] Wilson A, Hickie I, Lloyd A, Hadzi-Pavlovic D, Boughton C, Dwyer J, Wakefield D. Longitudinal study of outcome of chronic fatigue syndrome British Medical Journal 1994; 308:756-9.
[16] Wagner-Raphael LI, Jason LA, Ferrari JR. Chronic fatigue syndrome, chronic fatigue, and psychiatric disorders: Predictors of functional status in a national nursing sample. Journal of Occupational Health Psychology 1999; 4:63-71.
[17] Morriss R, Ahmed M, Wearden A, Mullis R, Strickland P, Appleby L, Campbell I, Pearson D. The role of depression in pain, psychophysiological syndromes and medically unexplained symptoms associated with chronic fatigue syndrome. Journal of Affective Disorders 1999; 55:143-8.
[18] Natelson BH, Johnson SK, DeLuca J, Sisto S, Ellis SP, Hill N, Bergen MT. Reducing heterogeneity in the chronic fatigue syndrome: A comparison with depression and multiple sclerosis. Clinical Infectious Diseases 1995; 21:1204-10.
[19] Jason LA, Torres-Harding S, Friedberg F, Corradi K, Njoku MG, Donalek J, Reynolds N, Brown M, Weitner BB, Rademaker A, Papernik M. Non-pharmacologic interventions for CFS: A randomized trial. Journal of Clinical Psychology in Medical Settings 2007; 14: 275-296
[20] Jason LA, Ropacki MT, Santoro NB, Richman JA, Heatherly W, Taylor R, Ferrari JR, Haney-Davis TM, Rademaker A, Dupuis JE, Golding J, Plioplys AV, Plioplys S. A screening instrument for chronic fatigue syndrome: Reliability and validity. Journal of Chronic Fatigue Syndrome 1997; 3:39-59.
[21] Hawk C, Jason L, Torres-Harding S. Reliability of a Chronic Fatigue Syndrome Questionnaire. Journal of Chronic Fatigue Syndrome 2007; 13:41-66.
[22] First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders, Clinician Version (SCID-CV). Washington, DC.: American Psychiatric Press, Inc.; 1996.
[23] Taylor RR, Jason LA. Comparing the DIS with the SCID: Chronic fatigue syndrome and psychiatric comorbidity. Psychology & Health 1998;13:1087-104.
[24] Brazier JE, Harper R, Jones NMB, OCathain A, Usherwood T, Westlake J. Validating the SF-36 Health survey questionnaire: new outcome measure for primary care. British Medical Journal 1992; 305: 160-4.
[25] McHorney CA, Ware JE, Raczek AE. The MOS 36-Item short form health survey (SF-36): II. Psychometric and Clinical Tests of validity in measuring physical and mental health constructs. Medical Care 1993; 31:247-63.
[26] McHorney CA, Ware JE, Lu AW, Sherbourne CD. The MOS 36-item Short-Form Health Survey (SF-36): III. Tests of data quality, scaling assumptions, and reliability across diverse patient groups. Medical Care 1994; 32:40-66.
[27] Buchwald D, Pearlman T, Umali J, Schmaling K, Katon W. Functional Status in Patients with Chronic Fatigue Syndrome, Other Fatiguing Illnesses, and Healthy Individuals. The American Journal of Medicine 1996;101:364-70.
[28] Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Archives of Neurology 1989; 46:1121-3.
[29] Pepper CM, Krupp LB, Friedberg F, Doscher C, Coyle PK. A comparison of neuropsychiatric characteristics in chronic fatigue syndrome, multiple sclerosis, and major depression. Journal of Neuropsychiatry and Clinical Neurosciences 1993; 5:200-5.
[30] Cohen J. Statistical Power Analysis for the Behavioral Sciences. Hillsdale, NJ Erlbaum; 1988.