Comparative Evaluation of the Biopharmaceutical and Chemical Equivalence of the Some Commercial Brands of Paracetamol Tablets
Acetaminophen (Paracetamol) tablets are popular OTC products among patients as analgesics and antipyretics. Paracetamol is marketed by a lot of suppliers around the world. The aim of the present investigation was to compare between many types of paracetamol tablets obtained from different suppliers (six brands produced by different pharmaceutical companies in middle east countries, and Panadol® manufactured in Ireland), by different quality control tests according to USP pharmacopeia.Using Non official tests-hardness and friability; official tests- disintegration, dissolution, and drug content. Additionally, evaluate the influence of temperatures 4°C, 25°C and 40°C at 75% relative humidity on the stability of the same brands in their original packaging has been conducted for two months. The results revealed that all paracetamol tablet brands complied with the official USP specifications. In conclusion, paracetamol tablets preferred to be stored at 25°C. All the tested brands being biopharmaceutically and chemically equivalent.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1076754Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2925
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 Malviya R., Srivastava P., preparation and evaluation of disintegrating properties of Cucurbita Maxima Pulp powder. International journal of pharmaceutical sciences, 2010, pp.119.
 Weise AM., Liu CY., Shield A.F, fatal liver failure in a patient on acetaminophen treated with sunitinib malate and levothyroxine.Ann pharmacother, 2009, 43(4):761-766.
 Lawrence J.,Moore E.,Port L.,Danchin M.,paracetamol as a risk factor for allergic disorders.The lancet,2009,pp.119-119.
 Persky V.,Piorkowski J., Hermandoz E.,parental exposure to acetaminophen and respiratory symptoms in the first year of life.Ann Aleegy Asthma Immunol,2008,101(3):271-278.
 Bamigbola EA., Ibrahim MA., Attama AA., comparative in-vitro assessment of soluble and plain brands of aspirin tablets marketed in Nigeria.Sci Res Essay, 2009, 11(4):1412-1414.