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Differentiation of Cancerous Prostate tissue from Non-Cancerous Prostate tissue by using Elastic Light Single-Scattering Spectroscopy: A Feasibility Study
Abstract:Elastic light single-scattering spectroscopy system with a single optical fiber probe was employed to differentiate cancerous prostate tissue from non-cancerous prostate tissue ex-vivo just after radical prostatectomy. First, ELSSS spectra were acquired from cancerous prostate tissue to define its spectral features. Then, spectra were acquired from normal prostate tissue to define difference in spectral features between the cancerous and normal prostate tissues. Of the total 66 tissue samples were evaluated from nine patients by ELSSS system. Comparing of histopathology results and ELSSS measurements revealed that sign of the spectral slopes of cancerous prostate tissue is negative and non-cancerous tissue is positive in the wavelength range from 450 to 750 nm. Based on the correlation between histopathology results and sign of the spectral slopes, ELSSS system differentiates cancerous prostate tissue from non- cancerous with a sensitivity of 0.95 and a specificity of 0.94.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1075074Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1167
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