Quantitative Indicator of Abdominal Aortic Aneurysm Rupture Risk Based on its Geometric Parameters
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Quantitative Indicator of Abdominal Aortic Aneurysm Rupture Risk Based on its Geometric Parameters

Authors: Guillermo Vilalta, Félix Nieto, Carlos Vaquero, José A. Vilalta

Abstract:

Abdominal aortic aneurysms rupture (AAAs) is one of the main causes of death in the world. This is a very complex phenomenon that usually occurs “without previous warning". Currently, criteria to assess the aneurysm rupture risk (peak diameter and growth rate) can not be considered as reliable indicators. In a first approach, the main geometric parameters of aneurysms have been linked into five biomechanical factors. These are combined to obtain a dimensionless rupture risk index, RI(t), which has been validated preliminarily with a clinical case and others from literature. This quantitative indicator is easy to understand, it allows estimating the aneurysms rupture risks and it is expected to be able to identify the one in aneurysm whose peak diameter is less than the threshold value. Based on initial results, a broader study has begun with twelve patients from the Clinic Hospital of Valladolid-Spain, which are submitted to periodic follow-up examinations.

Keywords: AAA, rupture risk prediction, biomechanical factors, AAA geometric characterization.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1074718

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References:


[1] Fillinger, M.F., Marra, P.S., Raghavan, M.L., Kennedy, E.F. (2003). Prediction of rupture in abdominal aortic aneurysm during observation: Wall stress versus diameter. J. Vasc. Surg.; 37:724-732.
[2] Kleinstreuer, C., Zhonghua, L. (2006). Analysis and computer program for rupture-risk prediction of abdominal aortic aneurysms. BioMedical Engineering OnLine, 5:19.
[3] Limet, R., Sakalihassan, N., Albert, A. (1991). Determination of the expansion rate and incidence of rupture of abdominal aortic aneurysms. J. Vasc. Surg.; 14:540-548.
[4] Papaharilaou, Y., Ekaterinaris, J., Manousaki, E., Katsamouris, A. (2007). A decoupled fluid structure approach of estimating wall stress in abdominal aortic aneurysms. Journal of Biomechanics, 2007, 40, 367- 377.
[5] Raghavan, M., Vorp, D., Federle, M., Makaroun, M., Webster, M. (2000). Wall stress distribution on three-dimensionally reconstructed models of human abdominal aortic aneurysm. J. Vasc. Surg. 31:760- 769.
[6] Scotti, C.M., Shkolnik, A.d., Muluk, S.C., Finol, E.A. (2005). Fluidstructure Interaction in Abdominal Aortic Aneurysm: Effects of Asymmetry and Wall Thickness. BioMedical Engineering OnLine, 4:64.
[7] Vande Geest, J., Di Martino, E., Bohra, A., Makaroun, M.S., Vorp. D. (2006). A Biomechanics-based Rupture Potential Index for Abdominal Aortic Aneurysm Risk Assessment." Ann. NY Acad. Sci. 1085:11.
[8] Vilalta, G., Nieto, F., Rodr├¡guez, M., Laurentiu, L., O'Connor, J., Dounié, O. (2009). Influence of abdominal aortic aneurysms geometry in the blood flow dynamics and in its rupture risk.(In Spanish). Ingenier├¡a Mec├ínica, 2:29-37.
[9] Wang, D., Makaroun, M., Webster, M., Vorp, D.A. (2002). Effect of intraluminal thrombus on wall stress in patient specific model of abdominal aortic aneurysm. J. Vasc. Surg. 3:598-604.
[10] Wilson, K., Lee, A.J., Hoskins, P.R., Fowkers, F.G., Ruckley, C.V., Bradbury, A.W. (2003). The relationship between aortic wall distensibility and rupture of infrarenal abdominal aortic aneurysm. J. Vasc. Surg. 37:112-117.