Arteriosclerosis and Periodontitis: Correlation Expressed in the Amount of Fibrinogen in Blood

Authors: Nevila Alliu, Saimir Heta, Ilma Robo, Vera Ostreni

Abstract:

Periodontitis as an oral pathology caused by specific bacterial flora functions as a focal infection for the onset and aggravation of arteriosclerosis. These two distant pathologies, since they affect organs at a distance from each other, communicate with each other with correlation at the level of markers of inflammation in the blood. Fluctuations in the level of fibrinogen in the blood, depending on the active or passive phase of the existing periodontitis, affect the promotion of arteriosclerosis. The study is of the brief communication article type with the aim to analyze the effect of non-surgical periodontal treatment on fluctuations in the level of fibrinogen in the blood. The reduction of fibrinogen's level in blood after non-surgical periodontal treatment of periodontitis in the patient's oral cavity, is a common consequence supported by literature sources. Also, the influence of a high amount of fibrinogen in blood on the occurrence of arteriosclerosis at the same patient, is also another important data that again rely on many sources of literature. Thromboembolism and arteriosclerosis, as risk factors expressed in clinical data, have temporary bacteremia in the blood, which can occur significantly and often between phases of non-surgical periodontal treatment of periodontitis, treatments performed with treatment phases and protocols of predetermined treatment. Arterial thromboembolism has a significant factor, such as high levels of fibrinogen in the blood, which are significantly reduced during the period of non-surgical periodontal treatment.

Keywords: Fibrinogen, refractory periodontitis, atherosclerosis, non-surgical, periodontal treatment.

References:

[1] Vidal F, Figueredo CM, Cordovil I, Fischer RG. Periodontal therapy reduces plasma levels of interleukin-6, C-reactive protein, and fibrinogen in patients with severe periodontitis and refractory arterial hypertension. J Periodontol. 2009;80:786-1.
[2] Hussain M, Stover CM, Dupont A. P. gingivalis in Periodontal Disease and Atherosclerosis -Scenes of Action for Antimicrobial Peptides and Complement. Front Immunol. 2015;10;6:45.
[3] Mackie IJ, Kitchen S, Machin SJ, Lowe GD. Haemostais and Thrombosis Task Force of the British Committee for standards in Haematology. Guidelines for fibrinogen assays. Br JHaemotol 2003;121:396-4.
[4] Jirina Bartova, Pavla Sommerova, Yelena Lyuya-Mi, et al. Periodontitis as a Risk Factor of Atherosclerosis. Journal of Immunology Research, 2014;2014:9.
[5] J. D. Beck and S. Offenbacher. The association between periodontal diseases and cardiovascular diseases: a state-of-the-science review. Annals of Periodontology, 2001;6;1:9–5.
[6] S. Heta, I. Robo. The Side Effects of the Most Commonly Used Group of Antibiotics in Periodontal Treatments. Med. Sci. 2018;6:6.
[7] M. S. Gomes, P. Chagas, D. M. Padilha. Association between self-reported oral health, tooth loss and atherosclerotic burden. Brazilian Oral Research, 2012;26:5:436–2.
[8] P. P. Hujoel, M. Drangsholt, C. Spiekerman, and T. A. DeRouen. Periodontal disease and coronary heart disease risk. The Journal of the American Medical Association, 2000;284:11:1406–0.
[9] Ilma Robo, Saimir Heta, Geriona Lasku, Vera Ostreni; „Prevalence of Chronic Periodontitis: A Retrospective Cross-sectional Study“; SciMedicine Journal; 2021;3:35-3.
[10] Ilma Robo, Saimir Heta, Nedja Hysi, Vera Ostreni. Analysis of Cross-Sectional and Retrograde Data on the Prevalence of Marginal Gingivitis. World Academy of Science, EngTechno, Open Science Index 166, International Journal of Medical and Health Sciences,2020;14:306 - 2.
[11] S. Heta, I. Robo, N.Alliu; „ Fibrinogen as an inflammatory marker of the connection of periodontits with arteriosclerosis“; J Clin Res in Dent, 2018;1,20-8.
[12] Magnusson I, Walker CB. Refractory periodontitis or recurrence of disease. JClinPeriodontol. 1996;23:289-2.
[13] Ilma Robo, Saimir Heta, Geriona Lasku, Vera Ostreni. Gingival recession and attachment loss: Cross-sectional and retrospective data of 10 years. J Adv P&I Dent, 2021:13;22-7.
[14] Shaddox, Luciana M; Walker, Clay B. Treating chronic periodontitis: status, challenges, and future directions. Clinical, Cos Invest Dent. 2010:2;79–1.
[15] Saimir Heta, Ilma Robo, Dariel Thereska, Nevila Alliu. Plasma levels of markers of inflammation, as expression of the interconnection of periodontitis with atherosclerosis. 24th Meeting of Balkan federation clinical laboratory, 2016:3;96-7.
[16] Heta, S., Robo, I., Alliu, N., Meta, T. "Inflammatory Markers in the Blood and Chronic Periodontitis". World Academy of Science, Engineering and Technology, Open Science Index 166, International Journal of Medical and Health Sciences, (2020), 14(10), 279 - 284.
[17] S. Heta, I. Robo; “The Side Effects of the Most Commonly Used Group of Antibiotics in Periodontal Treatments”; Med. Sci. 2018:6;60.
[18] Beck JD, Offenbacher S, Williams R, Gibbs P, Garcia R. Periodontitis: a risk factor for coronary heart disease? Ann Periodontol. 1998;3:127-1.
[19] Saffi MA, Furtado MV, Montenegro MM, Ribeiro IW, Kampits C, Rabelo-Silva ER, P et al. The effect of periodontal therapy on C-reactive protein, endothelial function, lipids and proinflammatory biomarkers in patients with stable coronary artery disease: study protocol for a randomized controlled trial. Trials. 2013;14:283.
[20] Bozoglan A, Ertugrul AS, Taspınar M, Yuzbasioglu B. Determining the relationship between atherosclerosis and periodontopathogenic microorganisms in chronic periodontitis patients. ActaOdontol Scand. 2017;75:233-2.
[21] Bokhari SA, Khan AA, Butt AK, Hanif M, Izhar M, Tatakis DN, et al. Periodontitis in coronary heart disease patients: strong association between bleeding on probing and systemic biomarkers. J ClinPeriodontol. 2014;41:1048-4.
[22] Gocke C, Holtfreter B, Meisel P, Grotevendt A, Jablonowski L, Nauck M, et al. Abdominal obesity modifies long-term associations between periodontitis and markers of systemic inflammation. Atherosclerosis. 2014;235:351-7.
[23] Androsz-Kowalska O, Jankowski K, Rymarczyk Z, Kowalski J, Pruszczyk P, Górska R. Correlation between clinical parameters of periodontal disease and mean platelet volume in patients with coronary artery disease: a pilot study. Kardiol Pol. 2013;71:600-5.
[24] Yu KM, Inoue Y, Umeda M, Terasaki H, Chen ZY, Iwai T. The periodontal anaerobe Porphyromonas gingivalis induced platelet activation and increased aggregation in whole blood by rat model. Thromb Res. 2011;127:418-5.
[25] López NJ, Chamorro A, Llancaqueo M. Association between atherosclerosis and periodontitis. Rev Med Chil. 2011;139:717-4.
[26] López NJ, Quintero A, Casanova PA, Ibieta CI, Baelum V, López R. Effects of periodontal therapy on systemic markers of inflammation in patients with metabolic syndrome: a controlled clinical trial.J Periodontol.2012;83:267-8.
[27] Amabile N. Severity of periodontal disease correlates to inflammatory systemic status and independently predicts the presence and angiographic extent of stable coronary artery disease. J Intern Med. 2008;263:644-52.
[28] Buhlin K. Risk factors for atherosclerosis in cases with severe periodontitis. J ClinPeriodontol. 2009;36:541-9.
[29] Leivadaros E, van der Velden U, Bizzarro S, ten Heggeler JM, Gerdes VE, Hoek FJ, et al. A pilot study into measurements of markers of atherosclerosis in periodontitis.J Periodontol.2005;76:121-8.
[30] Mattila KJ. Dental infections as a risk factor for acute myocardial infarction.Eur Heart J. 1993;14:51-3.
[31] Noites R, Teixeira M, Cavero-Redondo I, Alvarez-Bueno C, Ribeiro F. Apical Periodontitis and Cardiovascular Disease in Adults: A Systematic Review with Meta-Analysis. Rev Cardiovasc Med. 2022 Mar 12;23(3):100. doi: 10.31083/j.rcm2303100. PMID: 35345267.
[32] Jiménez C, Garrido M, Pussinen P, Bordagaray MJ, Fernández A, Vega C, Chaparro A, Hoare A, Hernández M. Systemic burden and cardiovascular risk to Porphyromonas species in apical periodontitis. Clin Oral Investig. 2022 Jan;26(1):993-1001. doi: 10.1007/s00784-021-04083-4. Epub 2021 Jul 27. PMID: 34313848.
[33] Jakovljevic A, Duncan HF, Nagendrababu V, Jacimovic J, Milasin J, Dummer PMH. Association between cardiovascular diseases and apical periodontitis: an umbrella review. Int Endod J. 2020 Oct;53(10):1374-1386. doi: 10.1111/iej.13364. Epub 2020 Aug 8. PMID: 32648971.
[34] Chauhan N, Mittal S, Tewari S, Sen J, Laller K. Association of Apical Periodontitis with Cardiovascular Disease via Noninvasive Assessment of Endothelial Function and Subclinical Atherosclerosis. J Endod. 2019 Jun;45(6):681-690. doi: 10.1016/j.joen.2019.03.003. Epub 2019 Apr 26. PMID: 31030979.
[35] Gomes MS, Hugo FN, Hilgert JB, Sant'Ana Filho M, Padilha DM, Simonsick EM, Ferrucci L, Reynolds MA. Apical periodontitis and incident cardiovascular events in the Baltimore Longitudinal Study of Ageing. Int Endod J. 2016 Apr;49(4):334-42. doi: 10.1111/iej.12468. Epub 2015 Jun 11. PMID: 26011008; PMCID: PMC5134837.
[36] Garrido M, Cárdenas AM, Astorga J, Quinlan F, Valdés M, Chaparro A, Carvajal P, Pussinen P, Huamán-Chipana P, Jalil JE, Hernández M. Elevated Systemic Inflammatory Burden and Cardiovascular Risk in Young Adults with Endodontic Apical Lesions. J Endod. 2019 Feb;45(2):111-115.doi:10.1016/j.joen. 2018. 11. 014. PMID: 30711165.
[37] Bergandi L, Giuggia B, Alovisi M, Comba A, Silvagno F, Maule M, Aldieri E, Scotti N, Scacciatella P, Conrotto F, Berutti E, Pasqualini D. Endothelial Dysfunction Marker Variation in Young Adults with Chronic Apical Periodontitis before and after Endodontic Treatment. J Endod. 2019 May;45(5):500-506. doi: 10.1016/j.joen.2019.01.018. Epub 2019 Mar 23. PMID: 30910354.