Ozone Therapy and Pulsed Electromagnetic Fields Interplay in Controlling Tumor Growth, Symptom and Pain Management: A Case Report
Background: The immune system has evolved several mechanisms to protect the host against cancer, and it has now been suggested that the expansion of its functions may prevent tumor growth and control the symptoms of cancer patients. Two techniques, ozone therapy and pulsed electromagnetic fields (PEMF), are independently associated with an increase in the immune system functions and they maybe help palliative care of patients in these conditions. Case Report: A patient with rectal adenocarcinoma with metastases decides to interrupt the clinical chemotherapy protocol due to refractoriness and side effects. As a palliative care alternative treatment it is suggested to the patient the use of ozone therapy associated with PEMF techniques. Results: The patient reports an improvement in well-being, in autonomy and in pain control. Imaging tests confirm a pause in tumor growth despite more than 60 days without using classic treatment. These results associated with palliative care alternative treatment stimulate the return to the chemotherapy protocol. Discussion: This case illustrates that these two techniques can contribute to the control of tumor growth and refractory symptoms, such as pain, probably by enhancing the immune system. Conclusions: The potential use of the combination of these two therapies, ozone therapy and PEMF therapy, can contribute to palliation of cancer patients, alone or in combination with pharmacological therapies. The conduct of future investigations on this paradigm can elucidate how much these techniques contribute to the survival and well-being of these patients.Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 300
 Ostroumov D, Fekete-Drimusz N, Saborowski M, Kühnel F, Woller N. CD4 and CD8 T lymphocyte interplay in controlling tumor growth. Cell Mol Life Sci. 2018 Feb;75(4):689-713. doi: 10.1007/s00018-017-2686-7. Epub 2017 Oct 14. PMID: 29032503; PMCID: PMC5769828.
 Cespedes-Suarez, Javier & Martin-Serrano, Yanisley & Carballosa-Peña, Maria & Dager-Carballosa, Diana. (2018). The immune response behavior in HIV-AIDS patients treated with Ozone therapy for two years. Journal of Ozone Therapy. 2. 10.7203/jo3t.2.3.2018.11458.
 Markov M, Ryaby J, Waldorff E. Pulsed Electromagnetic Fields for Clinical Applications.1st ed. Local: CRC Press; 2020.
 PROMOLIFE. O3ARC Standard Digital Ozone Generator. 2020. Available in: https://www.promolife.com/o3arc-digital-ozone-generator-standard/
 Bare JE. Resonant frequency therapy: building the rife beam ray device. Plastic Comb – Unabridged; 2002.
 Bare J. US 1999/5908441 A. Ressonant Frequency Therapy Device. Available in: https://patentimages.storage.googleapis.com/98/44/18/d476930eb25168/US5908441.pdf;
 Ressonant Light Tecnnology. PERL-M Plus device. 2020. Available in: https://www.resonantlight.com/perl-mplus/
 Viebahn-Haensler R and Lee A (eds): The Use of Ozone in Medicine. 5th edition. ODREI-Publishers, Iffezheim, p148, 2007. 2.
 Nogales CG, Ferrari PH, Kantorovich EO and Lage-Marques JL: Ozone therapy in medicine and dentistry. J Contemp Dent Pract 9: 75-84, 2008.
 Elvis AM, Ekta JS. Ozone therapy: A clinical review. J Nat Sci Biol Med. 2011 Jan;2(1):66-70. doi: 10.4103/0976-9668.82319. PMID: 22470237; PMCID: PMC3312702.
 Kuroda K, Yamashita M, Murahata Y, et al. Use of ozonated water as a new therapeutic approach to solve current concerns around antitumor treatment. Exp Ther Med. 2018;16(3):1597-1602. doi:10.3892/etm.2018.6415
 Smith, Joshuas & Oertle, John & Warren, Dan & Prato, Dino. (2015). Ozone Therapy: A Critical Physiological and Diverse Clinical Evaluation with Regard to Immune Modulation, Anti-Infectious Properties, Anti-Cancer Potential, and Impact on Anti-Oxidant Enzymes. Open Journal of Molecular and Integrative Physiology. 05. 37-48. 10.4236/ojmip.2015.53004.
 Jakab GJ, Spannhake EW, Canning BJ, Kleeberger SR, Gilmour MI. The effects of ozone on immune function. Environ Health Perspect. 1995 Mar;103 Suppl 2(Suppl 2):77-89. doi: 10.1289/ehp.95103s277. PMID: 7614952; PMCID: PMC1518840.
 Larini A, Aldinucci C, Bocci V. Ozone as a Modulator of the Immune System. Proceedings of The IEEE - PIEEE. 2001. Available in: https://www.researchgate.net/publication/237666795_OZONE_AS_A_MODULATOR_OF_THE_IMMUNE_SYSTEM
 Rosado MM, Simkó M, Mattsson MO, Pioli C. Immune-modulating perspectives for low frequency electromagnetic fields in innate immunity. Front Public Health. 2018 Mar 26;6:e85
 Markov M. Electromagnetic Fields in Biology and Medicine. Local: CRC Press; 2017 July 26.
 Markov M, Nindl G, Hazlewood C, Cuppen J. Interactions between electromagnetic fields and immune system: possible mechanism for pain control. Current Concepts. 2006 213–25.
 Ross C, Harrison B. An introduction to electromagnetic field therapy and immune function: a brief history and current status. J Sci Appl: Biomed. 2015;3(2)18-29.
 Walleczek J. Electromagnetic field effects on cells of the immune system: The role of calcium signaling. FASEB journal. 1992;6(13):3177-85.
 NICE - National Institute for Health and Care Excellence. NICE guideline. Care of dying adults in the last days of life. Published: 16 December 2015. nice.org.uk/guidance/ng31 Available in: https://www.nice.org.uk/guidance/ng31/resources/care-of-dying-adults-in-the-last-days-of-life-pdf-1837387324357
 North of England Cancer Network Palliative. Palliative and End of Life Care Guidelines. Fouth Edition, 2016. Available in: http://www.northerncanceralliance.nhs.uk/wp-content/uploads/2018/11/NECNXPALLIATIVEXCAREX2016-1.pdf
 Gordon GA. Designed electromagnetic pulsed therapy: clinical applications. J Cell Physiol. 2007;212(3):579-82.
 Cassileth BR. Complementary and alternative therapies for cancer. Oncologist. 2004;9(1):80-9.
 Cameron IL, Short NJ, Markov MS. Safe alternative cancer therapy using electromagnetic fields. Environmentalist. 2007;27(4): 453–6.
 Vadalà M, Morales-Medina JC, Vallelunga A, Palmieri B, Laurino C, Iannitti T. Mechanisms and therapeutic effectiveness of pulsed electromagnetic field therapy in oncology. Cancer Med. 2016 Nov;5(11):3128-39.
 Costa FP, de Oliveira R, Meirelles M, MacHado MC, Zanesco T, Surjan R, et al. Treatment of advanced hepatocellular carcinoma with very low levels of amplitude-modulated electromagnetic fields. Br J Cancer. 2011;105(5):640-8. doi:10.1038/bjc.2011.292
 Santana E et al. (2019). Exposure to low energy amplitude modulated radiofrequency electromagnetic fields (EMF) is associated with rapid improvement in quality of life (QoL) status in patients with advanced hepatocellular carcinoma (HCC), using various analyses of EORTC-C30. Annals of Oncology. 30.
 Yuan H, Ma Q, Ye L, Piao G. The traditional medicine and modern medicine from natural products. Molecules. 2016 Apr 29;21(5):e559.
 Tirard S, Morange M, Lazcano A. The definition of life: a brief history of an elusive scientific endeavor. Astrobiology. 2010 Dec;10(10):1003-9.
 Pal S. Complementary and alternative medicine: an overview. Current Science. 2002;82(5):518-24.
 Andrade FA, Portella CS. Research methods in complementary and alternative medicine: an integrative review. J Integr Med. 2018; 16(1):6–13.
 BRASIL. Ministério da Saúde Glossário temático de Práticas Integrativas e Complementares em Saúde. Brasilia, DF, 2018.
 Sousa I, Hortale V, Bodstein R. Traditional Complementary and Integrative Medicine: challenges in constructing an evaluation model of care. Cien Saude Colet. 2018 Oct;23(10):3403-12.
 Truant TL, Balneaves LG, Fitch MI. Integrating complementary and alternative medicine into cancer care: Canadian oncology nurses' perspectives. Asia Pac J Oncol Nurs. 2015 Oct-Dec;2(4):205-14.
 BRASIL. MINISTÉRIO DA SAÚDE. Resolução Nº 41, de 31 de Outubro De 2018. 2018b. Diário Oficial Da União, Available in: https://portalarquivos2.saude.gov.br/images/pdf/2018/novembro/23/RESOLUCAO-N41.pdf
 Zeng YS, Wang C, Ward KE, Hume AL. Complementary and alternative medicine in hospice and palliative care: a systematic review. J Pain Symptom Manage. 2018 Nov; 56(5):781-94.e4.
 Hall D. A new decade for biophysical reviews and a look into the future of biophysics. Biophys Rev. 2020;12(1):1–7.
 Figueiredo DM, Shimizu HE, Ramalho WM, de Figueiredo AM, Lucena KT. Quality of Primary Health Care in Brazil: patients’ view. Rev Bras Enferm. 2018;71(Suppl 6):2713-9.