Inflammatory Markers in the Blood and Chronic Periodontitis

Authors: Saimir Heta, Ilma Robo, Nevila Alliu, Tea Meta

Abstract:

Background: Plasma levels of inflammatory markers are the expression of the infectious wastes of existing periodontitis, as well as of existing inflammation everywhere in the body. Materials and Methods: The study consists of the clinical part of the measurement of inflammatory markers of 23 patients diagnosed with chronic periodontitis and the recording of parental periodontal parameters of patient periodontal status: hemorrhage index and probe values, before and 7-10 days after non-surgical periodontal treatment. Results: The level of fibrinogen drops according to the categorization of disease progression, active and passive, with the biggest % (18%-30%) at the fluctuation 10-20 mg/d. Fluctuations in fibrinogen level according to the age of patients in the range 0-10 mg/dL under 40 years and over 40 years was 13%-26%, in the range 10-20 mg/dL was 26%-22%, in the 20-40 mg/dL was 9%-4%. Conclusions: Non-surgical periodontal treatment significantly reduces the level of non-inflammatory markers in the blood. Oral health significantly reduces the potential source for periodontal bacteria, with the potential of promoting thromboembolism, through interaction between thrombocytes.

Keywords: Chronic periodontitis, atherosclerosis, risk factor, inflammatory markers.

References:

[1] Jirina Bartova, Pavla Sommerova, Yelena Lyuya-Mi, et al., “Periodontitis as a Risk Factor of Atherosclerosis,” Journal of Immunology Research, vol. 2014, Article ID 636893, 9 pages, 2014.
[2] J. D. Beck and S. Offenbacher, “The association between periodontal diseases and cardiovascular diseases: a state-of-the-science review,” Annals of Periodontology, vol. 6, no. 1, pp. 9–15, 2001.
[3] A. P. Dasanayake, “Poor periodontal health of the pregnant woman as a risk factor for low birth weight,” Annals of Periodontology, vol. 3, no. 1, pp. 206–212, 1998.
[4] M. S. Gomes, P. Chagas, D. M. Padilha et al., “Association between self-reported oral health, tooth loss and atherosclerotic burden,” Brazilian Oral Research, vol. 26, no. 5, pp. 436–442, 2012.
[5] P. P. Hujoel, M. Drangsholt, C. Spiekerman, and T. A. DeRouen, “Periodontal disease and coronary heart disease risk,” The Journal of the American Medical Association, vol. 284, no. 11, pp. 1406–1410, 2000.
[6] World Health Organisation- Cardiovascuval Diseases (CDVs) https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
[7] Ilma Robo, Saimir Heta, Fjona Hamzai, Vera Ostreni. The Effect of Conservative Periodontal Therapy in Patients with Systemic Diseases. Archives of Internal Medicine Research 2 (2019): 040-049.
[8] Carranza – Clinical periodontology; Mosby 2009; Kapitulli Mjekёsia Periodontale.
[9] D.E. Newby, N.R. Grubb, A. Bradbury; “Davidson’s Principles & Practice of Medicine” 21st ed. 2010.
[10] Brian L. Mealey, Perry R. Klokkevold “Carranza’s Clinic Periodontology 11th ed. 2012.
[11] D.E. Newby, N.R. Grubb, A. Bradbury “Davidson’s Principles & Practice of Medicine” 21st ed. 2010.
[12] M. John Novak and Karen F. Novak “Carranza’s Clinic Periodontology 11th ed. 2012
[13] S. Heta et al.; “Niveli plazmatik i markerave tё inflmacionit, si shprehёs i ndёrlidhjes sё periodontitit me arteriosklerozёn”; Albanian Stomatological Journal; Vёll.15; Nr.1-2 (56, 57); Mars 2017. nёntor 2017.
[14] Walker CB; “Refractory periodontitis or recurrence of disease”; J ClinPeriodontol. 1996 Mar;23(3 Pt 2):289-92.
[15] Shaddox, Luciana M; Walker, Clay B (2010-08-11). "Treating chronic periodontitis: current status, challenges, and future directions". Clinical, Cosmetic and Investigational Dentistry. 2: 79–91. ISSN 1179-1357. PMC 3645457. PMID 23662085.
[16] Heitz-Mayfield LJ, Schätzle M, Löe H, et al. (October 2003). "Clinical course of chronic periodontitis. II. Incidence, characteristics and time of occurrence of the initial periodontal lesion". J. Clin. Periodontol. 30 (10): 902–8. doi:10.1034/j.1600-051X.2003.00399.x. PMID 14710770. Archived from the original on 2013-01-05.
[17] Beck JD, Offenbacher S, Williams R, Gibbs P, Garcia R.; “Periodontitis: a risk factor for coronary heart disease?”; Ann Periodontol. 1998 Jul;3(1):127-41. Review.
[18] Mattila KJ.; “Dental infections as a risk factor for acute myocardial infarction.”; Eur Heart J. 1993 Dec;14 Suppl K:51-3. Review.
[19] Essentials of Clinical Periodontology and Periodontics 3rd Ed. (fq. 45-46)
[20] Newman Carranza’s Clinical Periodontology 11th Ed. (fq. 349)
[21] Clinical Problem Solving in Periodontology &Implantology (Elsevier) (fq. 13)
[22] Carranza – Clinical periodontology; Mosby 2009; Kapitulli Epidemiologjia.
[23] Hani H. Mawardi,Lena S. Elbadawi,Stephen T. Sonis, “Current understanding of the relationship between periodontal and systemic diseases”; Saudi Med J. 2015; 36(2): 150–158.
[24] Bozoglan A, Ertugrul AS, Taspınar M, Yuzbasioglu B; “Determining the relationship between atherosclerosis and periodontopathogenic microorganisms in chronic periodontitis patients.”; Acta Odontol Scand. 2017 May;75(4):233-242. doi: 10.1080/00016357.2017.1280739. Epub 2017 Jan 24.
[25] Bokhari SA, Khan AA, Butt AK, Hanif M, Izhar M, Tatakis DN, Ashfaq M; “Periodontitis in coronary heart disease patients: strong association between bleeding on probing and systemic biomarkers.”; J ClinPeriodontol. 2014 Nov;41(11):1048-54. doi: 10.1111/jcpe.12284. Epub 2014 Sep 11.
[26] Gocke C, Holtfreter B, Meisel P, Grotevendt A, Jablonowski L, Nauck M, Markus MR, Kocher T.; “Abdominal obesity modifies long-term associations between periodontitis and markers of systemic inflammation.”; Atherosclerosis. 2014 Aug;235(2):351-7. doi: 10.1016/j.atherosclerosis.2014.05.926. Epub 2014 May 22.
[27] Saffi MA, Furtado MV, Montenegro MM, Ribeiro IW, Kampits C, Rabelo-Silva ER, Polanczyk CA, Rösing CK, Haas AN.; “The effect of periodontal therapy on C-reactive protein, endothelial function, lipids and proinflammatory biomarkers in patients with stable coronary artery disease: study protocol for a randomized controlled trial.”;Trials. 2013 Sep 6;14:283. doi: 10.1186/1745-6215-14-283.
[28] Androsz-Kowalska O, Jankowski K, Rymarczyk Z, Kowalski J, Pruszczyk P, GórskaR.;”Correlation between clinical parameters of periodontal disease and mean platelet volume in patients with coronary artery disease: a pilot study.”; Kardiol Pol. 2013;71(6):600-5. doi: 10.5603/KP.2013.0124.
[29] López NJ, Chamorro A, Llancaqueo M.; “Association between atherosclerosis and periodontitis.; Rev Med Chil. 2011 Jun;139(6):717-24. doi: /S0034-98872011000600004. Epub 2011 Sep 14. Spanish.
[30] López NJ, Quintero A, Casanova PA, Ibieta CI, Baelum V, López R.; “Effects of periodontal therapy on systemic markers of inflammation in patients with metabolic syndrome: a controlled clinical trial.’; J Periodontol. 2012 Mar;83(3):267-78. doi: 10.1902/jop.2011.110227. Epub 2011 Jul 12.
[31] Yu KM, Inoue Y, Umeda M, Terasaki H, Chen ZY, Iwai T.; “The periodontal anaerobe Porphyromonasgingivalis induced platelet activation and increased aggregation in whole blood by rat model.”; Thromb Res. 2011 May;127(5):418-25. doi: 10.1016/j.thromres.2010.12.004. Epub 2011 Feb 18.
[32] Buhlin K, Hultin M, Norderyd O, Persson L, Pockley AG, Rabe P, Klinge B, Gustafsson A.; “Risk factors for atherosclerosis in cases with severe periodontitis.”; J ClinPeriodontol. 2009 Jul;36(7):541-9. doi: 10.1111/j.1600-051X.2009.01430.x.
[33] Amabile N, Susini G, Pettenati-Soubayroux I, Bonello L, Gil JM, Arques S, Bonfil JJ, Paganelli F.; “Severity of periodontal disease correlates to inflammatory systemic status and independently predicts the presence and angiographic extent of stable coronary artery disease.”; J Intern Med. 2008 Jun;263(6):644-52. doi: 10.1111/j.1365-2796.2007.01916.x. Epub 2008 Jan 16.
[34] Leivadaros E, van der Velden U, Bizzarro S, ten Heggeler JM, Gerdes VE, Hoek FJ, Nagy TO, Scholma J, Bakker SJ, Gans RO, ten Cate H, Loos BG.; “A pilot study into measurements of markers of atherosclerosis in periodontitis.”; J Periodontol. 2005 Jan;76(1):121-8.
[35] Ebersole JL, Cappelli D, Mott G, Kesavalu L, Holt SC, Singer RE.; “Systemic manifestations of periodontitis in the non-human primate.”; J Periodontal Res. 1999 Oct;34(7):358-62.