Amino Acid Based Biodegradable Amphiphilic Polymers and Micelles as Drug Delivery Systems: Synthesis and Study
Nanotherapy is an actual newest mode of treatment numerous diseases using nanoparticles (NPs) loading with different pharmaceuticals. NPs of biodegradable polymeric micelles (PMs) are gaining increased attention for their numerous and attractive abilities to be used in a variety of applications in the various fields of medicine. The present paper deals with the synthesis of a class of biodegradable micelle-forming polymers, namely ABA triblock-copolymer in which A-blocks represent amino-poly(ethylene glycol) (H2N-PEG) and B-block is biodegradable amino acid-based poly(ester amide) constituted of α-amino acid – L-phenylalanine. The obtained copolymer formed micelles of 70±4 nm size at 10 mg/mL concentration.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.3346702Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF
 V.P. Torchilin. Micellar Nanocarriers: Pharmaceutical Perspectives // Pharm Res.. 2007. Vol. 24, pp. 1-16
 V.P. Torchilin. Targeted polymeric micelles for delivery of poorly soluble drugs // CMLS, Cell. Mol. Life Sci.. 2004. Vol.61, pp 2549-2559
 Nie S, Xing Y, Kim GJ, Simons JW. Nanotechnology applications in cancer // Annul Rev Biomed Eng. 2007; Vol. 9, pp 257–88
 Gao Z, Lukyanov AN, Singhal A, Torchilin VP. Diacyllipid-polymer micelles as nanocarriers for poorly soluble anticancer drugs. Nano Lett. 2002; Vol. 2(9), pp 979–82.
 Davis ME, Chen Z, Shin DM. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat Rev Drug Discov. 2008; Vol 7(9), pp 771–82.
 Yifei Zhang, Yixian Huang, Song Li, Polymeric Micelles: Nanocarriers for Cancer-Targeted Drug Delivery. AAPS PharmSciTech. 2014; Vol 15(4), pp 862–871.
 Gaucher G, Dufresne MH, Sant VP, Kang N, Maysinger D, Leroux JC. Block copolymer micelles: preparation, characterization and application in drug delivery. J Control Release. 2005, Vol 109(1–3), pp 169–88.
 Sutton D, Nasongkla N, Blanco E, Gao J. Functionalized micellar systems for cancer targeted drug delivery. Pharm Res. 2007, Vol 24(6), pp 1029–46
 Choucair A, Eisenberg A. Control of amphiphilic block copolymer morphologies using solution conditions. Eur Phys J E Soft Matter. 2003, Vol 10(1), pp 37–44.
 Yu Y, Zhang L, Eisenberg A. Morphogenic effect of solvent on crew-cut aggregates of amphiphilic diblock copolymers. Macromolecules. 1998, Vol 31(4), pp 1144–54.
 Shen H, Zhang L, Eisenberg A. Multiple pH-induced morphological changes in aggregates of polystyrene-block-poly(4-vinylpyridine) in DMF/H2O mixtures. J Am Chem Soc. 1999, Vol 121(12), pp 2728–40
 Geng Y, Dalhaimer P, Cai S, Tsai R, Tewari M, Minko T, et al. Shape effects of filaments versus spherical particles in flow and drug delivery. Nat Nanotechnol. 2007, Vol 2(4), pp 249–55.
 Musacchio T., Torchilin V.P.. Advances in Polymeric and Lipid-core Micelles as Drug Delivery Systems // Polymeric Biomaterials: Medicinal and Pharmaceutical Applications. 2013.Vol. 2, pp. 65-82
 Wang Y, Ke CY, Weijie Beh C, Liu SQ, Goh SH, Yang YY. The self-assembly of biodegradable cationic polymer micelles as vectors for gene transfection // Biomaterials. 2007. Vol. 28, pp 5358-5368
 Knight DK, Gillies ER, Mequanint K. Strategies in functional poly (ester amide) syntheses to study human coronary artery smooth muscle cell interactions. Biomacromolecules. 2011Vol 12, pp 2475-2487
 R. Katsarava, Z. Gomurashvili. Biodegradable Polymers Composed of Naturally Occurring α-Amino Acids // Handbook of Biodegradable Polymer, Wiley-VCH. 2011. pp 107-131
 Rodriguez-Galan A., Franco L., Puiggali J.. Biodegradable Polyurethanes and Poly(ester amide)s // Handbook of Biodegradable Polymer, Wiley-VCH. 2011. pp 133-152
 Kobauri S., Torchilin V.P., Tugushi D., Katsarava R. PEG-PEA-PEG Triblock-copolymeric Micelles as Potential Biodegradable Nanocarriers for Pharmaceuticals // Contemporary Issues on Chemical Engineering, DAKAM Publishing. 2013. pp.41-45
 R.katsarava, D.Kharadze. The study of the stability of active phenyl esters of carboxylic acids in polar aprotic media // Zhur. Obshesh. Khimii (Russia), 1991, Vol 61(11), pp 2413-2418