Evaluating Health-Related Quality of Life of Lost to Follow-Up Tuberculosis Patients in Yemen

Authors: Ammar Ali Saleh Jaber, Amer Hayat Khan, Syed Azhar Syed Sulaiman

Abstract:

Tuberculosis (TB) is considered as a major disease that affects daily activities and impairs health-related quality of life (HRQoL). The impact of TB on HRQoL can affect treatment outcome and may lead to treatment defaulting. Therefore, this study aims to evaluate the HRQoL of TB treatment lost to follow-up during and after treatment in Yemen. For this aim, this prospective study enrolled a total of 399 TB lost to follow-up patients between January 2011 and December 2015. By applying HRQoL criteria, only 136 fill the survey during treatment. Moreover, 96 were traced and fill out the HRQoL survey. All eight HRQol domains were categorized into the physical component score (PCS) and mental component score (MCS), which were calculated using QM scoring software. Results show that all lost to follow-up TB patients reported a score less than 47 for all eight domains, except general health (67.3) during their treatment period. Low scores of 27.9 and 29.8 were reported for emotional role limitation (RE) and mental health (MH), respectively. Moreover, the mental component score (MCS) was found to be only 28.9. The trace lost follow-up shows a significant improvement in all eight domains and a mental component score of 43.1. The low scores of 27.9 and 29.8 for role emotion and mental health, respectively, in addition to the MCS score of 28.9, show that severe emotional condition and reflect the higher depression during treatment period that can result to lost to follow-up. The low MH, RE, and MCS can be used as a clue for predicting future TB treatment lost to follow-up.

Keywords: Yemen, tuberculosis, health-related quality of life, khat.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.2580962

References:

[1] Loosman WL, Hoekstra T, van Dijk S, Terwee CB, Honig A, Siegert CEH, et al. Short-Form 12 or Short-Form 36 to measure quality-of-life changes in dialysis patients? Nephrol Dial Transplant. 2015; 1–7. doi:10.1093/ndt/gfv066.
[2] Muniyandi M, Rajeswari R, Balasubramanian R, Nirupa C, Gopi PG, Jaggarajamma K, et al. Evaluation of post-treatment health-related quality of life (HRQoL) among tuberculosis patients. Int J Tuberc lung Dis. 2007; 11:887–92. http://www.ncbi.nlm.nih.gov/pubmed/17705955.
[3] Atif M, Syed Sulaiman S, Shafie A, Asif M, Sarfraz M, Low H, et al. Impact of tuberculosis treatment on health-related quality of life of pulmonary tuberculosis patients: a follow-up study. Health Qual Life Outcomes. 2014;12:19. doi:10.1186/1477-7525-12-19.
[4] Sharpe S, White A, Gleeson F, Mcintyre A, Smyth D, Clark S, et al. Ultra low dose aerosol challenge with Mycobacterium tuberculosis leads to divergent outcomes in rhesus and cynomolgus macaques. Tuberculosis. 2016; 96:1–12. doi: 10.1016/j.tube.2015.10.004.
[5] World Health Organization. Global tuberculosis report 2014. 2014.
[6] Jaber AAS, Khan AH, Sulaiman SAS, Ahmad N, Anaam MS. Evaluation of Health-Related Quality of Life among Tuberculosis Patients in Two Cities in Yemen. PLoS One. 2016; 1–19.
[7] Jaber AAS, Khan AH, Sulaiman SAS. Evaluating treatment outcomes and durations among cases of smear-positive pulmonary tuberculosis in Yemen: a prospective follow-up study. J Pharm Policy Pract. 2017;10:36. doi:10.1186/s40545-017-0124-8.
[8] World Health Organization. Treatment of tuberculosis guidelines. 2010.
[9] Fernandez Z. International Standard For Tuberculosis care. 2014.
[10] Ware JE, Kosinski M, Bjorner JB, Turner-Bowker DM, Gandek B, Maruish ME. User’s manual for the SF-36v2 health survey. 2008.
[11] Kruijshaar ME, Lipman M, Essink-Bot M-L, Lozewicz S, Creer D, Dart S, et al. Health status of UK patients with active tuberculosis. Int J Tuberc lung Dis. 2010;14:296–302.
[12] Marra CA, Marra F, Colley L, Moadebi S, Elwood K, Fitzgerald JM. Health-Related Quality of Life Trajectories Among Adults With Tuberculosis * Differences Between Latent and Active Infection. Int J Tuberc Lung Dis. 2008.
[13] Chang B, Wu AW, Hansel NN, Diette GB. Quality of life in tuberculosis: A review of the English language literature. Qual Life Res. 2004;13:1633–42.
[14] Chamla D. The assessment of patients’ health-related quality of life during tuberculosis treatment in Wuhan, China. Int J Tuberc Lung Dis. 2004. http://www.ingentaconnect.com/content/iuatld/ijtld/2004/00000008/00000009/art00010. Accessed 5 May 2015.
[15] Wang R, Wu C, Zhao Y, Yan X, Ma X, Wu M, et al. Health related quality of life measured by SF-36: a population-based study in Shanghai, China. BMC Public Health. 2008;8:292.
[16] Aghanwa HS, Erhabor GE. Demographic/socioeconomic factors in mental disorders associated with tuberculosis in southwest Nigeria. J Psychosom Res. 1998;45:353–60.
[17] Kastien-Hilka T, Sinanovic E, Schwenkglenks M, Bennett B, Rosenkranz B. Health-related quality of life and its association to medication adherence in pulmonary tuberculosis in South Africa - A systematic review of qualitative and quantitative literature. Health Qual Life Outcomes. 2016;20:356.
[18] Shafie AA, Atif M, Sulaiman SAS, Asif M, Zahari CD. Normative data, discriminative properties and equivalence of SF-36v2 health survey in Malaysian population. Lat Am J Pharm. 2012;31:1117–25.
[19] Atif M, Sulaiman SAS, Shafie AA, Asif M, Ahmad N. SF-36v2 norms and its’ discriminative properties among healthy households of tuberculosis patients in Malaysia. Qual Life Res. 2013;22:1955–64.
[20] Atif M, Toghrayee Z, Sulaiman SAS, Shafie AA, Low HC, Babar Z-U-D. Missing Data Analysis in Longitudinal Studies: Findings from a Quality of Life Study in Malaysian Tuberculosis Patients. Appl Res Qual Life. 2014;10:95–105. doi:10.1007/s11482-014-9302-x.
[21] Rajeswari R, Muniyandi M, Balasubramanian R, Narayanan PR. Perceptions of tuberculosis patients about their physical, mental and social well-being: a field report from south India. Soc Sci Med. 2005;60:1845–53.
[22] Vinaccia S, Quiceno JM, Férnandez H, Pérez BE, Sánchez MO, Londoño A. Calidad de vida relacionada con la salud y apoyo social percibido en pacientes con diagnóstico de tuberculosis pulmonar. An Psicol. 2007;23:245–52.
[23] Chan-Yeung M, Noertjojo K, Leung CC, Chan SL, Tam CM. Prevalence and predictors of default from tuberculosis treatment in Hong Kong. Hong Kong Med J. 2003;9:263–8.
[24] Guo N, Marra F, Marra C a. Measuring health-related quality of life in tuberculosis: a systematic review. Health Qual Life Outcomes. 2009;7:14.
[25] Al-Qahtani MF, El.Mahalli AA, Al Dossary N, Al Muhaish A, Al Otaibi S, Al Baker F. Health-related quality of life of tuberculosis patients in the Eastern Province, Saudi Arabia. J Taibah Univ Med Sci. 2014;9:311–7.
[26] Ware JE, Kosinski M, Bjorner JB, Turner BDM, Maruish ME: User's manual for the SF-36v2 health survey. 2nd edition Lincoln, RI: Quality Metric Incorporated; 2007.
[27] Lam CLK, Tse EYY, Gandek B, Fong DYT: The SF-36 summary scales were valid, reliable, and equivalent in a Chinese population. J Clin Epidemiol 2005, 58:815–822.