Fabrication of Poly(Ethylene Oxide)/Chitosan/Indocyanine Green Nanoprobe by Co-Axial Electrospinning Method for Early Detection
Early detection of cancer could save human life and quality in insidious cases by advanced biomedical imaging techniques. Designing targeted detection system is necessary in order to protect of healthy cells. Electrospun nanofibers are efficient and targetable nanocarriers which have important properties such as nanometric diameter, mechanical properties, elasticity, porosity and surface area to volume ratio. In the present study, indocyanine green (ICG) organic dye was stabilized and encapsulated in polymer matrix which polyethylene oxide (PEO) and chitosan (CHI) multilayer nanofibers via co-axial electrospinning method at one step. The co-axial electrospun nanofibers were characterized as morphological (SEM), molecular (FT-IR), and entrapment efficiency of Indocyanine Green (ICG) (confocal imaging). Controlled release profile of PEO/CHI/ICG nanofiber was also evaluated up to 40 hours.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1474761Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 313
 C. Zheng, “Indocyanine green-loaded biodegradable tumor targeting nanoprobes for in vitro and in vivo imaging,” in Biomaterials, vol. 44, April 2012, pp. 5603–5609.
 C. Yue, “IR-780 dye loaded tumor targeting theranostic nanoparticles for NIR imaging and photothermal therapy,” in Biomaterials, vol. 34, May 2013, pp. 6853–6861.
 T. Desmettre, “Fluoresence Properties and Metabolic Features of Indocyanine Green (ICG) as Related to Angiography” in Survey of Ophthalmology, vol. 45 July 2000, pp. 15-27.
 S. Vishal, “Polymeric nanoparticulate delivery system for Indocyanine green: biodistribution in healthy mice” in Int. J. Pharm, vol. 308, February 2006, pp. 200-204.
 M. Pakravan, “A fundamental study of chitosan/PEO electrospinning,” in Polymer, vol. 52, August 2011, pp. 4813-4824.
 M. Sadri, “New Chitosan/Poly(ethylene oxide/Thyme Nanofiber Prepared by Electrospinning Method for Antimicrobial Wound Dressing,”, in Nanostruct, vol. 4, September 2016, pp. 322-328.
 Z. C. Yao, C. Zhang, Z. Ahmad, J. Huang, J. S. Li, M. W. Chang, “Designer fibers from 2D to 3D Simultaneous and controlled engineering of morphology, shape and size,” Chemical Engineering journal., vol. 2, Oct. 2017, pp. 89–98.
 Z. R. Ege, A. Akan, F. N. Oktar, C. C. Lin, B. Karademir, O. Gunduz, “Encapsulation of indocyanine green in poly(lactic acid) nanofibers for using as a nanoprobe in biomedical diagnostics,” Materials Letters, vol. 228, June 2018, pp.148–151.
 F. Cheng, J. Gao, L. Wang, X. Hu, “Composite chitosan/poly(ethylene oxide) electrospun nanofibrous mats as novel wound dressing matrixes for the controlled release of drugs,” J. APPL. POLYM. SCI., January 2015, pp. 42060-42068.