A Literature Review on Nutritional Supplements for the Treatment of Obesity
The problem of obesity is one that continues to be faced in the United States health care system and across the developing world. Prescription medications are available, but are often very expensive with minimal insurance coverage. The over-the-counter diet aid industry is a robust one, selling billions of dollars in products every year. It is important for clinicians to understand the myriad of different nutritional supplements marketed for obesity, and to weigh the evidence behind these products. This manuscript outlines the most commonly used nutritional supplements currently marketed for weight loss, reviewing the evidence with a focus on the efficacy and safety of these products.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1316430Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1578
 Centers of Disease Control and Prevention. “Prevalence of Obesity among Adults and Youth: United States, 2011–2014.” 2015. https://www.cdc.gov/nchs/data/databriefs/db219.pdf. Accessed 4/20/2017.
 Hill J. “Understanding and addressing the epidemic of obesity: an energy balance perspective.” Endocr Rev., Vol 27 no. 7, pp 750-761, 2006.
 Hammond R, Levine R. The economic impact of obesity in the United States. Diabetes Metab Syndr Obes., Vol 3, pp 285-295, 2010.
 Jensen M, Ryan D, Apovian C, et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. Circulation, volume 129, no. 25 supplement 2, pp S102-138, 2014.
 Gallup Poll. “America’s desire to shed pounds outweighs efforts. 2013. http://www.gallup.com/poll/166082/americans-desire-shed-pounds-outweighs-effort.aspx. Accessed 4/20/2017.
 IBISWorld. “Weight Loss Services in the US Industry Market Research Report from IBISWorld Has Been Updated” July 22, 2013. http://www.prweb.com/releases/2013/7/prweb10948232.htm. Accessed 4/20/2017.
 Natural Medicines™ Database. 2016. https://naturalmedicines.therapeuticresearch.com/ Accessed 4/20/2017.
 Landor M, Benami A, Segev N, Loberant B. “Efficacy and acceptance of a commercial Hoodia parviflora product for support of appetite and weight control in a consumer trial.” J Med Food. Vol 18 no. 2, pp 250-255, 2015.
 Kuriyan, R., Raj T, Srinivas S, Vaz M, et al. "Effect of Caralluma fimbriata extract on appetite, food intake and anthropometry in adult Indian men and women." Appetite Vol 48 no. 3, pp 338-344, 2007.
 Astell, K, Mathai L, McAinch A, Stathis C, Su X. "A pilot study investigating the effect of Caralluma fimbriata extract on the risk factors of metabolic syndrome in overweight and obese subjects: a randomised controlled clinical trial." Complement Ther Med Vol 21 no. 3, pp 180-189, 2013.
 Ceci F, Cangiano C, Cairella M, et al. “The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects.” J Neural Transm vol 76, pp 109-117, 1989.
 Cangiano C, Laviano A, Del Ben M, et al. “Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients.” Int J Obes Relat Metab Disord Vol 22, pp 648-654, 1998.
 Chutkan, R., Fahey G, Wright W, McRorie J. "Viscous versus nonviscous soluble fiber supplements: mechanisms and evidence for fiber-specific health benefits." J Am Acad Nurse Pract vol 24, no. 8, pp 476-487, 2012.
 Anderson, J, Baird P, David R, et al. "Health benefits of dietary fiber." Nutr Rev vol 67 no. 4, pp 188-205, 2009.
 Liu S, Willett W, Manson J, Hu F, et al. “Relation between changes in intakes of dietary fiber and grain products and changes in weight and development of obesity among middle-aged women.” Am J Clin Nutr. Vol 78, no. 5, pp 920-927, 2003.
 Du H, van der A, Boshuizen H, et al. “Dietary fiber and subsequent changes in body weight and waist circumference in European men and women”, Am J Clin Nutr.Vol 91, no. 2, pp 329-336, 2010.
 Ernst E, Pittler M. “Chitosan as a treatment for body weight reduction? A meta-analysis.” Perfusion Vol 11, pp 461-465, 1998.
 Jull AB, Ni Mhurchu C, Bennett D, Dunshea-Mooij C, Rodgers A. “Chitosan for overweight or obesity.” Cochrane Database of Systemic Reviews, Issue 3, 2008.
 Liu, A., Smith S, Fujioka K, Greenway F. "The effect of leptin, caffeine/ephedrine, and their combination upon visceral fat mass and weight loss." Obesity (Silver Spring) Vol 21, no. 10, pp 1991-1996. 2013.
 Shekelle P, Hardy M, Morton S, et al. "Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta-analysis." JAMA Vol 289, no. 12, pp 1537-1545, 2003.
 Stohs S, Preuss H, Shara M. "A review of the human clinical studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine." Int J Med Sci Vol 9 no. 7, pp 527-538, 2012.
 Stohs S, Preuss H, Shara M. “A review of the receptor-binding properties of p-synephrine as related to its pharmacological effects.” Oxid Med Cell Longevity pp 1-9, 2011.
 Kaats G, Miller H, Preuss H, Stohs S. "A 60 day double-blind, placebo-controlled safety study involving Citrus aurantium (bitter orange) extract." Food Chem Toxicol Vol 55, pp 358-362, 2013.
 Henry C, Emery B. "Effect of spiced food on metabolic rate." Hum Nutr Clin Nutr Vol 40 No.2 pp 165-168, 1986.
 Yoshioka M, St-Pierre S, Suzuki M, Tremblay A. "Effects of red pepper added to high-fat and high-carbohydrate meals on energy metabolism and substrate utilization in Japanese women." Br J Nutr Vol 80 No.6, pp 503-510, 1998.
 Snitker S, Fujishima Y, Shen H, et al. "Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications." Am J Clin Nutr Vol 89 No. 1, pp45-50, 2009.
 United States Food and Drug Administration. "Aristolochic Acid: FDA Warns Consumers to Discontinue Use of Botanical Products that Contain Aristolochic Acid." 2001. https://www.fda.gov/Food/RecallsOutbreaksEmergencies/SafetyAlertsAdvisories/ucm096388.htm. Accessed 4/18/2017.
 Henderson S, Magu B, Rasmussen C, et al. “Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women.” J Int Soc Sports Nutr.Vol 2, pp 54-62, 2005.
 Godard M, Johnson B, Richmond S. “Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men.” Obes Res.Vol 13, No. 8, pp 1335-1343, 2015.
 Roongpisuthipong C, Kantawan R, Roongpisuthipong W. "Reduction of adipose tissue and body weight: effect of water soluble calcium hydroxycitrate in Garcinia atroviridis on the short term treatment of obese women in Thailand." Asia Pac J Clin Nutr Vol 16 No. 1, pp 25-29, 2007.
 Heymsfield S, Allison B, Vasselli J, Pietrobelli A, et al. “Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial." JAMA Vol 280 No.18, pp 1596-1600, 1998.
 Pramyothin P, Janthasoot W, Pongnimitprasert N, Phrukudom S, Ruangrungsi N. "Hepatotoxic effect of (+)usnic acid from Usnea siamensis Wainio in rats, isolated rat hepatocytes and isolated rat liver mitochondria." J Ethnopharmacol Vol. 90 No.2-3, pp 381-387, 2004.
 Onakpoya I, Davies L, Posadzki P, Ernst E. "The efficacy of Irvingia gabonensis supplementation in the management of overweight and obesity: a systematic review of randomized controlled trials." J Diet Suppl Vol 10 No.1, pp 29-38, 2013.
 Ngondi J, Etoundi B, Nyangono C, et al. “IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigation.” Lipids Health Dis Vol 8, No. 7, 2009.
 Ngondi J, Oben J, Minka S. “The effect of Irvingia gabonensis seeds on body weight and blood lipids of obese subjects in Cameroon.” Lipids Health Dis. Vol 4, No. 12, 2005.
 Oben J, Ngondi J, Momo C, et al. “The use of a Cissus quadrangualris/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study.” Lipids Health Dis. Vol. 7, No. 44, 2008.
 Huang J, Zhang Y, Zhou Y, et al. "Green tea polyphenols alleviate obesity in broiler chickens through the regulation of lipid-metabolism-related genes and transcription factor expression." J Agric Food Chem Vol. 61, No.36, pp 8565-8572, 2013.
 Yan J, Zhao Y, Zhao B. "Green tea catechins prevent obesity through modulation of peroxisome proliferator-activated receptors." Sci China Life Sci Vol 56 No.9, pp 804-810, 2013.
 Pittler M, Stevinson C, Ernst E. “Chromium picolinate for reducing body weight: met-analysis of randomized trials.” Int J Obes Relat Metab Disord Vol 27, pp 522-529, 2003.
 Trent L, Thieding-Cancel D. “Effects of chromium picolinate on body composition.” J Sports Med Phys Fitness Vol 35, pp 273-280, 1995.
 Smedman A, Vessby B. “Conjugated linoleic acid supplementation in humans- metabolic effects.” Lipids Vol 36, pp 773-781, 2001.
 Racine N, Watras A, Carrel A, et al. “Effect of conjugated linoleic acid on body fat accretion in overweight or obese children.” Am J Clin Nutr Vol 91, No. 5, pp 1157-1164, 2010.
 Onakpoya I, Hunt K, Wider B, Ernst E. “Pyruvate supplementation for weight loss: a systematic review and meta-analysis of randomized clinical trials.” Crit Rev Food Sci Nutr.Vol 54, No. 1, pp 17-23, 2014.
 Ushiki M, Ikemoto T, Sato Y. “Anti-obese activities of raspberry ketone.” Aroma Research Vol 3, pp361, 2002.
 Lopez H, Ziegenfuss T, Hofheins, J et al. “Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women.” J Int Soc Sports Nutr Vol 10, no. 1, pp 22, 2013.