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The Effect of Physical Activity and Responses of Leptin

Authors: Sh. Khoshemehry, M. J. Pourvaghar, M. E. Bahram


In modern life, daily physical activity is relatively reduced, which is why the incidence of some diseases associated with overweight and obesity, such as hypertension, diabetes and other chronic illnesses, even in young people are observed. Obesity and overweight is one of the most common metabolic disorders in industrialized countries and in developing countries. One consequence of pathological obesity is cardiovascular disease and metabolic syndrome. In the past, it was believed that adipose tissue was ineffective and served only for storing triglycerides. In this review article, it was tried to refer to the esteemed scientific sources about physical activity and responses of leptin.

Keywords: Disease, leptin, obesity, physical activity.

Digital Object Identifier (DOI):

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[1] A. H. Haghighi, H. Yarahmadi, A. DarAbadi, A. Rafieepour. “The effect of aerobic training on serum levels of ghrelin and leptin in middle-aged men, ”Daneshvar med, 19(97):84-95, 2012.
[2] H. Mohebbi, F. Fatahi, H. Faraji, M. Mohammad-Mohseni. “The effect of upper and lower limb resistance training on leptin in overweight men” Int J Sport Studies, 3 (12):1318-24, 2013.
[3] C. Martins, L. M. Morgan, S. R. Bloom, M. D. Robertson. “Effects of exercise on gut peptides, energyintake and appetite” J Endocrinol, 193(2): 251-8, 2007.
[4] M. Hakimi, M. Ali-Mohammadi, “Comparison between the effects of a resistance training combined with massage, PNF and static stretching on performance in non-athlete male students” Int J Sport Studies, 4(1): 37-44, 2014.
[5] M. Fasshauer, J. Klein, U. Lossner, R. Paschke. “Interleukin (IL)-6 mRNA Expression Is Stimulated by Insulin, Isoproterenol, Tumour Necrosis Factor Alpha, Growth Hormone, and IL-6 in 3T3-L1 Adipocytes,” HormMetab Res,35(3):147-52, 2003.
[6] Y, Zhang, P. J. Scarpace, “The Role of Leptin in Leptin Resistance and Obesity,” PhysiolBehav, 88(3):249-56, 2006.
[7] M. Eizadi, M. Karimi, M. Kohandel, H. Duali.“Effect of aerobic exercise on serum leptin response and insulin resistance of patients with type 2 diabetes,” JQUMS, 16(4): 33-39, 2013.
[8] F. Daryanoosh, M. Mehboodi, M. Mortazavi, E. Motesharee. “The Effect of 8 weeks of intense aerobic exercise on plasma levels of obestatin, leptin, insulin and growth hormones in male obese Sprague,” AMUJ; 17(90): 37-45, 2014.
[9] F. Thong, R. Hudson, R. Ross, I. Janssen, T. Graham, “Plasma leptin in moderately obese men: independent effects of weight loss and aerobic exercise,” AJP- Endo; 279(2):307-13, 2000.
[10] Kh. Moonikh, M. Kashef, A. Azad, A. Ghasemnian. “Effects of 6 weeks resistance training on Body Composition, serum Leptin and muscle strength in non-athletic men,” QHMS; 21(2):135-140, 2015.
[11] JF. Burr, CP. Rown, VK. Jamink, MC. Riddle. “The role of physical activity in type 2 diabetes prevention: physiological and practical perspectives,” Phys Sports Med, 38 (1):72-82, 2010.
[12] L. Qin, Y. Xiang, Z. Song, R. Jing, C. Hu, ST. Howard. “Erythropoietinas a possible mechanism for the effects ofintermittent hypoxia on bodyweight, serum glucose andleptin,” RegulPept, 165 (2-3):168-73, 2010.
[13] R. Soori, N. Rezaeian, O. Salehian. “Effects of Interval Training on Leptin and Hormone levels Affecting Lipid Metabolism in Young Obese/Overweight Men,” Iranian Journal of Endocrinology and Metabolism,14(3):248-305, 2012.
[14] M. Hakimi, D. Sheikh Vatani, M. Ali-Mohammadi. “Effect of eight weeks with a combination of resistance training (resistance-massage) on serum leptin, lipid profile and body composition in overweight 139 young men,” Sport physiology,2(3):2-15, 2014.
[15] S. Khalili, R. Nuri, M. Moghadassi, M. Mogharnasi. “Leptin and Insulin Resistance in Young Adult Obese Females: Effect of Eight Weeks Resistance Training,” Research in Endocrinology, Vol. 2014, Article ID 665365, 8 pages, 2014.
[16] Sh. Sohaily, R. Soori, N. Rezaeian. “Hormonal adaptations to moderate-intensity endurance training in sedentary obese men,” Koomesh, 14(2):181-191, 2013.
[17] Z. Hojjati, F. Rahmaninia, B. Soltani, N. Rahnama. “Acute effect of aerobic and resistance exercise on serum leptin and some of heart coronary dangers factors in obese girls,” Olympic J,16(2):7-17, 2008.
[18] M. Glaister, H. Hauck, CS. Abraham, KL. Merry, D. Beaver, B. Woods, G. McInnes. “Familiarization, reliability, and comparability of a 40-m maximal shuttle run test, J Sports Sci Med,8(1):77-82, 2009.
[19] A. Esteghamati, O. Khalilzadeh, H. Ashraf, et al. “Physical activity is correlated with serum leptin independent of obesity: results of the national surveillance of risk factors of noncommunicable diseases in Iran (SuRFNCD-2007),” Metabolism, 59(12):1730-5, 2010.
[20] T. Fuentes, I. Ara, A. Guadalupe-Grau, S. Larsen, B. Stallknecht, H. Olmedillas, et al. “Leptin Receptor 170 kDa(OB-R170) Protein Expression Is Reduced in Obese Human Skeletal Muscle: A Potential Mechanism of Leptin Resistance. ExpPhysiol, 95(1):160-71, 2010.
[21] R. Otsuka, H. Yatsuya, K. Tamakoshi, K. Matsushita, K. Wada, H. Toyoshima, “Perceived psychological stress and serum leptin concentrations in Japanese men, Obesity, 14(10):1832-8, 2006.
[22] RL. Leibel, M. Resenbaum, J. Hirsch. “Changes inenergy expenditure resulting from altered body weight,” N Engl J Med,332(10):621-28, 1995.
[23] R. Rezaee Shirazi, “Effects of 12 weeks high intensity interval training on plasma Adiponectin, Leptin and insulin resistance in obese males with non-alcoholic fatty liver,” Metabolism and Exercise, A bioannual journal, 5(1):25-37, 2015.
[24] R. Pratley, B. Nicklas, M. Rubin, J. Miller, A. Smith, M. Smith, A. Goldberg. “Strength training increases resting metabolic rate and norepinephrine levels in healthy 50- to 65-year-old men,” J ApplPhysiol, 76(1):133-37, 1994.
[25] F. Yamaner, T. Bayraktaroglu, H. Atmaca, MA. Ziyagil, K. Tamer. “Serum leptin, lipoprotein levels, and glucose homeostasis between nationalwrestlers and sedentary males,” Turk J MedSci, 40(3): 471-7, 2010.
[26] SD. Weise, PW. Grandjean, JJ. Rohack, JW. Womack, SF. Crouse. “Acute changes in blood lipids and enzymes in postmenopausal women after exercise,” J ApplPhysiol, 99(2): 609-15, 2005.
[27] U. Wisloff, A. Stoylen, JP. Loennechen, M. Bruvold, O. Rognmo, PM. Haram, et al. “Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: A randomized study,” Circulation, 115(24):3086-94, 2007.
[28] K. Lenk, R. Schur, A. Linke, S. Erbs, Y. Matsumoto, V. Adams, G. Schuler, “Impact of exercise training on myostatin expression in the myocardium and skeletal muscle in a chronic heart failure model,” Eur J Heart Fail,11(4): 342-8, 2009.
[29] K. Salehzadeh, AA. Gaeini. “Effects of selected long-term aerobic exercises on serum leptin level of non-athlete young men and women,” JQUMS; 16 (4): 26-32, 2013.
[30] M. Hosseini, M. Nikbakht, A. Habibi, A. Ahangarpour, H. Fathi Moghaddam, “Acute Effects of an Aerobic Exhaustive Incremental Exercise Session on Serum Leptin and Plasma Lipids,” Sci Med J, 10(4):363-371, 2011.
[31] D. Stejskal, M. Karpisek, Hanulova Z, et al. “Chemerin is an independent marker of the metabolic syndrome in a Caucasian population--a pilot study”. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 152: 217-21, 2008.
[32] B. Dong, W. Ji, Y. Zhang, “Elevated serum chemerin levels are associated with the presence of coronary artery disease in patients with metabolic syndrome,” Inter Med, 50 (10): 1093-97, 2011.