Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 30121
Investigation of Solvent Effect on Viscosity of Lubricant in Disposable Medical Devices

Authors: Hamed Bagheri, Seyd Javid Shariati

Abstract:

The effects of type and amount of solvent on lubricant which is used in disposable medical devices are investigated in this article. Two kinds of common solvent, n-Hexane and n-Heptane, are used. The mechanical behavior of syringe has shown that n-Heptane has better mixing ratio and also more effective spray process in the barrel of syringe than n-Hexane because of similar solubility parameter to silicon oil. The results revealed that movement of plunger in the barrel increases when pure silicone is used because non-uniform film is created on the surface of barrel, and also, it seems that the form of silicon is converted from oil to gel due to sterilization process. The results showed that the convenient mixing ratio of solvent/lubricant oil is 80/20.

Keywords: Disposable medical devices, lubricant oil, solvent effect, solubility parameter.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1131353

Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 744

References:


[1] M Petersen, Syringe Siliconization Trends, Methods, Analysis Procedures. International pharmaceutical industry, Vol 4, pp. 92-99. Atu 2012.
[2] M. K Kawaguchi, “Silicone oil emulsions stabilized by polymers and solid particles” Adv Colloid Interface Sci, pp 1-14, Jul 2015.
[3] E. Krayukina. K. Tsomoto, K. “Effects of Syringe Material and Silicone Oil Lubrication on the Stability of Pharmaceutical Proteins” Journal of Pharmaceutical Sciences, Vol. 104 527–535. Feb 2015.
[4] W. Brostow, D. Pietkiewicz, and S. R. Wisner, Polymer tribology in safety medical devices: Retractable syringes. Advances in Polymer Technology, Vol. 26(1): p. 56-64. Mar 2007.
[5] D. B. Ludwig, Flow cytometry: a promising technique for the study of silicone oil-induced particulate formation in protein formulations. Anal Biochem, Vol 41(2) pp.-191-199. Mar. 2011.
[6] J. Lee, C. Park, G. Whitesides "Solvent Compatibility of Poly(dimethylsiloxane)-Based Microfluidic Devices " Anal. Chem. Vol 75, pp. 6544-6554. Dec.2003.