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Bone Mineral Density and Trabecular Bone Score in Ukrainian Men with Obesity

Authors: Vladyslav Povoroznyuk, Anna Musiienko, Nataliia Dzerovych, Roksolana Povoroznyuk


Osteoporosis and obesity are widespread diseases in people over 50 years associated with changes in structure and body composition. Нigher body mass index (BMI) values are associated with greater bone mineral density (BMD). However, trabecular bone score (TBS) indirectly explores bone quality, independently of BMD. The aim of our study was to evaluate the relationship between the BMD and TBS parameters in Ukrainian men suffering from obesity. We examined 396 men aged 40-89 years. Depending on their BMI all the subjects were divided into two groups: Group I – patients with obesity whose BMI was ≥ 30 kg/m2 (n=129) and Group II – patients without obesity and BMI of < 30 kg/m2 (n=267). The BMD of total body, lumbar spine L1-L4, femoral neck and forearm were measured by DXA (Prodigy, GEHC Lunar, Madison, WI, USA). The TBS of L1- L4 was assessed by means of TBS iNsight® software installed on DXA machine (product of Med-Imaps, Pessac, France). In general, obese men had a significantly higher BMD of lumbar spine L1-L4, femoral neck, total body and ultradistal forearm (p < 0.001) in comparison with men without obesity. The TBS of L1-L4 was significantly lower in obese men compared to non-obese ones (p < 0.001). BMD of lumbar spine L1-L4, femoral neck and total body significantly differ in men aged 40-49, 50-59, 60-69, and 80-89 years (p < 0.05). At the same time, in men aged 70-79 years, BMD of lumbar spine L1-L4 (p=0.46), femoral neck (p=0.18), total body (p=0.21), ultra-distal forearm (p=0.13), and TBS (p=0.07) did not significantly differ. A significant positive correlation between the fat mass and the BMD at different sites was observed. However, the correlation between the fat mass and TBS of L1-L4 was also significant, though negative.

Keywords: Bone mineral density, trabecular bone score, obesity, men.

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[1] M. J. Gonçalves, A. M. Rodrigues, H. Canhão, J. E. Fonseca “Osteoporosis: from bone biology to individual treatment decision,” Acta Med. Port., vol. 26, no. 4, pp. 445-55, 2013.
[2] J. J. Cao “Effects of obesity on bone metabolism,” J. Orthop. Surg. Res., vol. 15, no. 6, p. 30, 2011.
[3] W. D. Leslie, E. S. Orwoll, C. M. Nielson, S. N. Morin, S. R. Majumdar, H. Johansson, A. Odén, E. V McCloskey, J. A. Kanis “Estimated Lean Mass and Fat Mass Differentially Affect Femoral Bone Density and Strength Index but Are Not FRAX Independent Risk Factors for Fracture,” J Bone Miner Res., vol. 29, no. 11, pp 2511–2519, 2014.
[4] A. Faje, A. Klibanski “Body composition and skeletal health: too heavy? Too thin?,” Curr. Osteoporos. Rep., vol. 10, no. 3, pp. 208-16, 2012.
[5] Nutrition, Physical Activity and Obesity // Available online: Accessed on 12 Jan 2017.
[6] S. Gonnelli, C. Caffarelli, R. Nuti “Obesity and fracture risk,” Clin. Cases Miner. Bone Metab., vol. 11, no. 1, pp. 9-14, 2014.
[7] B. A. Gower, K. Casazza “Divergent effects of obesity on bone health,” J. Clin. Densitom., vol. 16, no. 4, pp. 450-4, 2013.
[8] S. Lv, A. Zhang, W. Di, Y. Sheng, P. Cheng, H. Qi, J. Liu, J. Yu, G. Ding, J. Cai & B. Lai. “Assessment of Fat distribution and Bone quality with Trabecular Bone Score (TBS) in Healthy Chinese Men,” Scientific Reports, vol. 26, pp 1–8, 2016.
[9] D. Naot, J. Cornish “Cytokines and Hormones That Contribute to the Positive Association between Fat and Bone,” Front Endocrinol (Lausanne), vol. 9, no. 5, p. 70, 2014.
[10] C. M. Nielson, P. Srikanth, E. S. Orwoll “Obesity and fracture in men and women: an epidemiologic perspective,” J. Bone Miner. Res., vol. 27, no. 1, pp. 1-10, 2012.
[11] C. J. Rosen, M. L. Bouxsein “Mechanisms of disease: is osteoporosis the obesity of bone?,” Nature clinical practice, vol. 2 no. 1, pp. 35-43, 2006.
[12] S. Sharma, T. V. Randon, S. Mahajan et al. “Obesity: Friend or foe for osteoporosis,” J. Midlife Health, vol. 5, no. 1, pp. 6-9, 2014.
[13] C. De Laet, J. A. Kanis, A. Oden, et al. “Body mass index as a predictor of fracture risk: a meta‐analysis,” Osteoporos Int., vol. 16, pp. 1330–1338, 2005.
[14] C. M. Nielson, L. M. Marshall, A. L. Adams, E. S. LeBlanc, P. M. Cawthon, K. Ensrud, M. L. Stefanick, E. Barrett‐Connor, E. S. Orwoll “Osteoporotic Fractures in Men Study Research Group. BMI and fracture risk in older men: the osteoporotic fractures in men study (MrOS) ,” J Bone Miner Res., vol. 26, no. 3, pp 496–502, 2011.
[15] M. O. Premaor, J. E. Compston, F. F.Avilés, A. Pagès‐Castellà, X. Nogués, A. Díez‐Pérez, D. Prieto‐Alhambra “The Association Between Fracture Site and Obesity in Men: A Population‐Based Cohort Study,” J Bone Miner Res., vol. 28, no. 8, pp 1771–1777. 2013.
[16] Y. H. Hsu, S. A. Venners, Henry A Terwedow, Y. Feng, T. Niu, Z. Li, N. Laird, J. D. Brain, S. R. Cummings, M. L. Bouxsein, C. J. Rosen, X. Xu “Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women,” Am J Clin Nutr., vol. 83, pp. 146 –54, 2006.