Bone Mineral Density and Quality, Body Composition of Women in the Postmenopausal Period
In the diagnostics of osteoporosis, the gold standard is considered to be bone mineral density; however, X-ray densitometry is not an accurate indicator of osteoporotic fracture risk under all circumstances. In this regard, the search for new methods that could determine the indicators not only of the mineral density, but of the bone tissue quality, is a logical step for diagnostic optimization. One of these methods is the evaluation of trabecular bone quality. The aim of this study was to examine the quality and mineral density of spine bone tissue, femoral neck, and body composition of women depending on the duration of the postmenopausal period, to determine the correlation of body fat with indicators of bone mineral density and quality. The study examined 179 women in premenopausal and postmenopausal periods. The patients were divided into the following groups: Women in the premenopausal period and women in the postmenopausal period at various stages (early, middle, late postmenopause). A general examination and study of the above parameters were conducted with General Electric X-ray densitometer. The results show that bone quality and mineral density probably deteriorate with advancing of postmenopausal period. Total fat and lean mass ratio is not likely to change with age. In the middle and late postmenopausal periods, the bone tissue mineral density of the spine and femoral neck increases along with total fat mass.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1130147Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 578
 V. Povoroznyuk, N. I. Dzerovych “Trabecular bone score in women if different age”, Pain. Joints. Spine, 2011, vol. 4, pp. 29-31.
 V. Povoroznyuk, N. I. Dzerovych “Trabecular bone score in women depending on duration of postmenopausal period”, Pain. Joints. Spine, 2012, vol. 2, pp. 11-15.
 V. V. Povoroznyuk “Postmenopausal osteoporosis: the mechanisms of risk factors, clinical features, diagnosis, prevention and treatment” // Pediatrics, Obstetrics and Gynecology, 1998, vol. 2, pp. 98-111.
 V. V. Povoroznyuk, O. M. Boris “The relationship between the structural and functional state of bone and anthropometric indices in women in pre- and postmenopausal”, Diseases of the musculoskeletal system in people of all ages (selected lectures, reviews, articles), 2004, – vol. 1, pp. 459-478.
 S. Boutroy, D. Hans, E. Sornay-Rendu et al. “Trabecular bone score improves fracture risk prediction in non-osteoporotic women: the OFELY study”, Osteoporos Int, 2013, vol 24, no 1, pp. 77-85.
 D. Hans, A. L. Goertzen, M. A. Krieg et al. “Bone microarchitecture assessed by TBS predicts osteoporotic fractures independent of bone density: the Manitoba study”, J. Bone Miner. Res, 2011, vol. 26. – pp. 2762-2769.
 C. Cormier, O. Lamy, S. Poriau “TBS in routine clinical practice: proposals of use”, Atlas of TBS use, Edition 2012, 2012. – 16 p.
 D. Hans, R. Winzenrieth “Estimation of Bone microarchitecture Pattern from AP spine DXA scansusing the Trabecular Bone Score (TBS): An added value in clinical routine for the patient”, A short revive, Osteologicky bulletin, 2011, vol. 16, no 3, pp. 70-78.
 R. Winzenrieth, R. Dufour, L. “Pothuaud et al. A retrospective Case-control study assessing the role of trabecular bone score in postmenopausal caucasian women with osteopenia: analysing the odds of vertebral fracture”, Calcif. Tissue Int, 2010, vol. 86. pp. 104-109.
 W. D. Leslie, J. Kanis “Lumbar spine TBS is a FRAX independent risk factor for fracture. The Manitoba BMD Cohort”, Program and abstract book (ISCD Annual meeting 2013, Tampa, Florida), 2013, pp. 12-15.
 V. Bousson, C. Bergot, B. Sutter et al. “Trabecular bone score (TBS): available knowledge, clinical relevance, and future prospects”, Osteoporos Int, 2012, vol. 23, no 5, pp. 1489-1501.
 J. Vasic, T. Petranova, V. Povoroznyuk et al. “Evaluating spine micro-architectural texture (via TBS) discriminates major osteoporotic fractures from controls both as well as and independent of site matched BMD: the Eastern European TBS study”, J Bone Miner Metab, 2014, vol. 32, no 5. – pp. 556-562.
 W. Kim, S. G. Chung, K. Kim et al. “The relationship between body fat and bone mineral density in Korean men and women”, J Bone Miner Metab, 2014, vol. 32, no 6. – pp. 709-717.
 L. G. Machado, D. S. Domiciano, C. P. Figueiredo et al. “Visceral fat measured by DXA is associated with increased risk of non-spine fractures in nonobese elderly women: a population-based prospective cohort analysis from the São Paulo Ageing & Health (SPAH) Study”, Osteoporos Int, 2016, pp. 17-20.