Effects of High-Protein, Low-Energy Diet on Body Composition in Overweight and Obese Adults: A Clinical Trial

Authors: Makan Cheraghpour, Seyed Ahmad Hosseini, Damoon Ashtary-Larky, Saeed Shirali, Matin Ghanavati, Meysam Alipour

Abstract:

Background: In addition to reducing body weight, the low-calorie diets can reduce the lean body mass. It is hypothesized that in addition to reducing the body weight, the low-calorie diets can maintain the lean body mass. So, the current study aimed at evaluating the effects of high-protein diet with calorie restriction on body composition in overweight and obese individuals. Methods: 36 obese and overweight subjects were divided randomly into two groups. The first group received a normal-protein, low-energy diet (RDA), and the second group received a high-protein, low-energy diet (2×RDA). The anthropometric indices including height, weight, body mass index, body fat mass, fat free mass, and body fat percentage were evaluated before and after the study. Results: A significant reduction was observed in anthropometric indices in both groups (high-protein, low-energy diets and normal-protein, low-energy diets). In addition, more reduction in fat free mass was observed in the normal-protein, low-energy diet group compared to the high -protein, low-energy diet group. In other the anthropometric indices, significant differences were not observed between the two groups. Conclusion: Independently of the type of diet, low-calorie diet can improve the anthropometric indices, but during a weight loss, high-protein diet can help the fat free mass to be maintained.

Keywords: Diet, high-protein, body mass index, body fat percentage.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1128885

References:

[1] D. M. Nguyen, H. B. El-Serag. “The epidemiology of obesity,” Gastroenterol Clin North Am, vol.39, 2010, pp. 1-7.
[2] G. Koochakpoor, M. S. Daneshpour, P. Mirmiran, et al. “The effect of interaction between Melanocortin-4 receptor polymorphism and dietary factors on the risk of metabolic syndrome,” Nutr Metab (Lond), vol.13, 2016, pp. 35.
[3] C.L. Ogden, M. D. Carroll, M. A. McDowell, et al. “Obesity among adults in the United States-no statistically significant chance since 2003-2004,” NCHS Data Brief, vol.1, 2007, pp. 1-8.
[4] C. L. Ogden, S. Z. Yanovski, M. D. Carroll, et al. “The epidemiology of obesity,” Gastroenterol, vol.132, 2007, pp. 2087-2102.
[5] H. Rashidi, S. P. Payami, S. M. Latifi, et al. “Prevalence of metabolic syndrome and its correlated factors among children and adolescents of Ahvaz aged 10 - 19,” J Diabetes Metab Disord, vol.13, 2014, pp.53.
[6] K. Cheraghpoor, E. Ehrampoush, R. Shahbazi, et al. “Evaluation and Compare the Indices of Body Adiposity in Ahvaz University Students,” Jundishapur Sci Med J, vol.14, 2015, pp. 533-549.
[7] M, Ladhani, J.C Craig, m. Irving, et al. “Obesity and the risk of cardiovascular and all-cause mortality in chronic kidney disease: a systematic review and meta-analysis,” Nephrol Dial Transplant, 2016, (Epub ahead of print).
[8] L. Gilardini, G. Redaelli, m. Croci, et al., “Effect of a Modest Weight Loss in Normalizing Blood Pressure in Obese Subjects on Antihypertensive Drugs,” Obes Facts, vol. 9, 2016, pp. 251-258, (Epub ahead of print).
[9] P. J. Joris, J. Plat J, Y. H. Kusters. “Diet-induced weight loss improves not only cardiometabolic risk markers but also markers of vascular function: a randomized controlled trial in abdominally obese men,” Am J Clin Nutr, (Epub ahead of print).
[10] A. N. Howard. “The historical development, efficacy and safety of very-low-calorie diets,” Int J Obes, vol. 5, 1981, pp. 195-208.
[11] S.A. Hosseini, A. Ahangarpour, M. Ghanavati et al., “Review effects of ginseng on improving glycemic status and other related parameters with Type 2 diabetes,” J Clin Exc, vol. 4, 2015, pp. 90-107.
[12] M. Samadi, F. Zeinaly, S. Ghotbodin Mohammadi, et al., “The relationship between obesity and dietary patterns: review on evidence,” J Clin Exc, vol. 4, 2014, pp. 72-89.
[13] M. Ghanavati, M. Behrooz, B. Rashidkhani, et al., “Healthy Eating Index in Patients with Cataract: A Case-Control Study,” Iran Red Crescent Med J, vol.17, 2015, e22490.
[14] S. A. Hosseni, S. Shirali, M. Ghanavati, M. Alipour, “Role of Nutrition in Epigenetic Modulation as a Preventive and Therapeutic Approach for Cancer,” International Journal of Pharmaceutical Research & Allied Sciences, vol.5, 2016, pp. 218-226.
[15] E. Normandin, E. Doucet, R. Rabasa-Lhoret, et al. “Effects of a weight loss program on body composition and the metabolic profile in obese postmenopausal women displaying various obesity phenotypes: a MONET group study,” Appl Physiol Nutr Metab, vol. 40, 2015, pp. 695-702.
[16] N. M. Byrne, R. L. Weinsier, G. R. Hunter, et al. “Influence of distribution of lean body mass on resting metabolic rate after weight loss and weight regain: comparison of responses in white and black women,” Am J Clin Nutr, vol. 77, 2003, pp. 1368-73.
[17] I. Janssen, S. B. Heymsfield, R. Ross. “Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability,” J Am Geriatr Soc, vol. 50, 2002, pp. 889-896.
[18] K. D. Tipton. “Muscle protein metabolism in the elderly: influence of exercise and nutrition,” Can J Appl Physiol, vol. 26, 2001, pp. 588–606.
[19] W. M. Rand, P. L. Pellett, V. R. Young. “Meta-analysis of nitrogen balance studies for estimating protein requirements in healthy adults,” Am J Clin Nutr, vol. 77, 2003, pp. 109–127.
[20] S. J. Caton, B. Yinglong, L. Burget, et al. “Low-carbohydrate high-fat diets: regulation of energy balance and body weight regain in rats,” Obesity (Silver Spring), vol. 17, 2009, pp. 283-9.
[21] D. Gallagher, D. E. Kelley, J. Thornton. “Changes in skeletal muscle and organ size after a weight-loss intervention in overweight and obese type 2 diabetic patients,” Am J Clin Nutr, 2016, (Epub ahead of print).
[22] J. W. Carbone, L. M. Margolis, J. P. McClung, et al. “Effects of energy deficit, dietary protein, and feeding on intracellular regulators of skeletal muscle proteolysis,” FASEB J, vol. 27, 2013, pp. 5104–11.
[23] W. J. Kraemer, G. Solomon-Hill, B. M. Volk, et al. “The effects of soy and whey protein supplementation on acute hormonal reponses to resistance exercise in men,” J Am Coll Nutr, vol. 32, 2013, pp. 66–74.
[24] J. Eisenstein, S. B. Roberts, G. Dallal, et al., “Highprotein weight-loss diets: are they safe and do they work? A review of the experimental and epidemiologic data,” Nutrition Reviews, vol. 60, 2002, pp. 189–200.
[25] German Nutrition Society, Reference Values for Nutrient Intake (Deutsche Gesellschaft f¨ur Ern¨ahrung e. V., DGE, Referenzwerte f¨ur die N¨ahrstoffzufuhr), Neuer Umschau Buchverlag, Neustadt an derWeinstraße, Germany, 2008.
[26] H. J. Leidy, N.S. Carnell, R. D. Mattes, et al. “Higher protein intake preserves lean mass and satiety with weight loss in pre-obese and obese women,” Obesity (Silver Spring), vol. 15, 2007, pp. 421–9.
[27] J. A. Gilbert, N. T. Bendsen, A. Tremblay, et al. “Effect of proteins from different sources on body composition,” Nutr Metab Cardiovasc Dis, vol. 21, 2011, pp. 16–31.
[28] S. Soenen, E. A. P. Martens, A. Hochstenbach-Waelen, et al. “Normal protein intake is required for body weight loss and weight maintenance, and elevated protein intake for additional preservation of resting energy expenditure and fat free mass,” J Nutr, vol. 143, 2013, pp. 591–6.
[29] E. Farnsworth, N. D. Luscombe, M. Noakes, et al., “Effect of a high-protein, energyrestricted diet on body composition, glycemic control, and lipid concentrations in overweight and obese hyperinsulinemic men and women,” American Journal of Clinical Nutrition, vol. 78, 2003, pp. 31–39.
[30] D. K. Layman, D. A. Walker. “Potential importance of leucine in treatment of obesity and the metabolic syndrome,” Journal of Nutrition, vol. 136, 2006, pp. 319–323.
[31] M. P. Harber, S. Schenk, A. L. Barkan, et al. “Effects of dietary carbohydrate restriction with high protein intake on protein metabolism and the somatotropic axis,” Journal of Clinical Endocrinology and Metabolism, vol. 90, 2005, pp. 5175–5181.
[32] K. J. Petzke, S. Lemke, S. Klaus. “Increased Fat-Free Body Mass and No Adverse Effects on Blood Lipid Concentrations 4 Weeks after Additional Meat Consumption in Comparison with an Exclusion of Meat in the Diet of Young Healthy Women,” Journal of Nutrition and Metabolism, vol. 2011, 2011, pp.1-8.
[33] S. Mettler, N. Mitchell, K. D. Tipton. “Increased protein intake reduces lean body mass loss during weight loss in athletes,” Med Sci Sports Exerc, vol. 42, 2010, pp. 326-37.
[34] S.M. Pasiakos, J. J. Cao, L. M. Margolis, et al. “Effects of high-protein diets on fat-free mass and muscle protein synthesis following weight loss: a randomized controlled trial,” FASEB J, vol. 27, 2013, pp. 3837-47.
[35] T. M. Longland, S. Y. Oikawa, C. J. Mitchell, et al. “Higher compared with lower dietary protein during an energy deficit combined with intense exercise promotes greater lean mass gain and fat mass loss: a randomized trial,” Am J Clin Nutr, vol. 103, 2016, pp. 738-46.
[36] J. Antonio, C. A. Peacock, A. Ellerbroek, et al. “The effects of consuming a high protein diet (4.4 g/kg/d) on body composition in resistance-trained individuals,” J Int Soc Sports Nutr, vol.11, 2014, pp. 19.
[37] S. Soenen, M. S. Westerterp-Plantenga. “Changes in body fat percentage during body weight stable conditions of increased daily protein intake vs. control,” Physiol Behav, vol. 101, 2010, pp. 635–638.
[38] K. J. Petzke, S. Lemke, S. Klaus. “Increased fat-free body mass and no adverse effects on blood lipid concentrations 4 weeks after additional meat consumption in comparison with an exclusion of meat in the diet of young healthy women,” J Nutr Metab, vol 2011, Article ID: 210930.