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Effect of Aging on the Second Law Efficiency, Exergy Destruction and Entropy Generation in the Skeletal Muscles during Exercise
Abstract:The second law muscle work efficiency is obtained by multiplying the metabolic and mechanical work efficiencies. Thermodynamic analyses are carried out with 19 sets of arms and legs exercise data which were obtained from the healthy young people. These data are used to simulate the changes occurring during aging. The muscle work efficiency decreases with aging as a result of the reduction of the metabolic energy generation in the mitochondria. The reduction of the mitochondrial energy efficiency makes it difficult to carry out the maintenance of the muscle tissue, which in turn causes a decline of the muscle work efficiency. When the muscle attempts to produce more work, entropy generation and exergy destruction increase. Increasing exergy destruction may be regarded as the result of the deterioration of the muscles. When the exergetic efficiency is 0.42, exergy destruction becomes 1.49 folds of the work performance. This proportionality becomes 2.50 and 5.21 folds when the exergetic efficiency decreases to 0.30 and 0.17 respectively.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1340058Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1082
 J. Szargut, D. R. Morris, and F. R. Steward, "Exergy analysis of thermal, chemical, and metallurgical processes," 1987.
 N. Heglund and G. Cavagna, "Mechanical work, oxygen consumption, and efficiency in isolated frog and rat muscle," American Journal of Physiology-Cell Physiology, Vol. 253, pp. C22-C29, 1987.
 M. A. Rahman, "A novel method for estimating the entropy generation rate in a human body," Thermal Science, Vol. 11, pp. 75-92, 2007.
 I. Dincer and Y. A. Cengel, "Energy, entropy and exergy concepts and their roles in thermal engineering," Entropy, Vol. 3, pp. 116-149, 2001.
 S. A. Jubrias, N. K. Vollestad, R. K. Gronka, and M. J. Kushmerick, "Contraction coupling efficiency of human first dorsal interosseous muscle," The Journal of Physiology, Vol. 586, pp. 1993-2002, 2008.
 M. Shukuya, M. Saito, K. Isawa, T. Iwamatsu, and H. Asada, "Human-Body Exergy Balance and Thermal Comfort," Report submitted for the final report of the IEA ECBCS Annex, Vol. 49, 2009.
 C. E. K. Mady, M. S. Ferreira, J. I. Yanagihara, P. H. N. Saldiva, and S. de Oliveira Junior, "Modeling the exergy behavior of human body," Energy, Vol. 45, pp. 546-553, 2012.
 C. E. K. Mady, Oliveira, Jr. S. , " Human body exergy metabolism," in The 25th International conference on efficiency, cost, optimization, simulation and environmental impact of energy systems, Perugia, Italy, 2012, pp. 1-13.
 J. Çatak, A. Ç. Develi, E. Sorguven, M. Özilgen, and H. S. İnal, "Lifespan entropy generated by the masseter muscles during chewing: an indicator of the life expectancy?," International Journal of Exergy, Vol. 18, pp. 46-67, 2015.
 E. Sorgüven and M. Özilgen, "First and second law work production efficiency of a muscle cell," International Journal of Exergy, Vol. 18, pp. 142-156, 2015.
 R. K. Josephson, "Mechanical power output from striated muscle during cyclic contraction," Journal of Experimental Biology, Vol. 114, pp. 493-512, 1985.
 G. H. Pollack, Muscles & Molecules: Uncovering the Principles of Biological Motion. Seattle, WA: Ebner & Sons, 1990.
 J. Szargut, "Exergy analysis," The Magazine of Polish Academy of Sciences, Vol. 3, pp. 31-33, 2005.
 A. L. Clark, P. A. Poole-Wilson, and A. J. Coats, "Exercise limitation in chronic heart failure: central role of the periphery," Journal of the American College of Cardiology, Vol. 28, pp. 1092-1102, 1996.
 G. Lenaz, M. D’Aurelio, M. M. Pich, M. Genova, B. Ventura, C. Bovina, et al., "Mitochondrial bioenergetics in aging," Biochimica et Biophysica Acta (BBA)-Bioenergetics, Vol. 1459, pp. 397-404, 2000.
 E. V. Menshikova, V. B. Ritov, L. Fairfull, R. E. Ferrell, D. E. Kelley, and B. H. Goodpaster, "Effects of exercise on mitochondrial content and function in aging human skeletal muscle," The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Vol. 61, pp. 534-540, 2006.
 S. Volianitis and N. Secher, "Arm blood flow and metabolism during arm and combined arm and leg exercise in humans," The Journal of physiology, Vol. 544, pp. 977-984, 2002.
 G. Ahlborg and M. Jensen‐Urstad, "Metabolism in exercising arm vs. leg muscle," Clinical Physiology, Vol. 11, pp. 459-468, 1991.
 T. Brink-Elfegoun, L. Kaijser, T. Gustafsson, and B. Ekblom, "Maximal oxygen uptake is not limited by a central nervous system governor," Journal of applied physiology, Vol. 102, pp. 781-786, 2007.
 S. Strange, "Cardiovascular control during concomitant dynamic leg exercise and static arm exercise in humans," The Journal of physiology, Vol. 514, pp. 283-291, 1999.
 E. Pedersen, S. Kozerke, S. Ringgaard, M. Scheidegger, and P. Boesiger, "Quantitative abdominal aortic flow measurements at controlled levels of ergometer exercise," Magnetic resonance imaging, Vol. 17, pp. 489-494, 1999.
 A. F. Huxley, "Muscle structure and theories of contraction," Prog. Biophys. Biophys. Chem, Vol. 7, pp. 255-318, 1957.
 A. Hill, "The heat of shortening and the dynamic constants of muscle," Proceedings of the Royal Society of London B: Biological Sciences, Vol. 126, pp. 136-195, 1938.
 N. P. Smith, C. J. Barclay, and D. S. Loiselle, "The efficiency of muscle contraction," Progress in Biophysics and Molecular Biology, Vol. 88, pp. 1-58, 2005.
 R. D. Feinman and E. J. Fine, "" A calorie is a calorie" violates the second law of thermodynamics," Nutrition journal, Vol. 3, p. 1, 2004.
 M. Mariūnas, K. Daunoravičienė, J. Griškevicius, and J. Andrašiutė, "383. Research of relation between muscle biosignal and systolic blood pressure, and application of its characteristics for evaluation of efficiency"Journal of Vibroengineering, Vol. 10, pp. 329-334, 2008.
 C. Barclay, "Efficiency of fast-and slow-twitch muscles of the mouse performing cyclic contractions," Journal of Experimental Biology, Vol. 193, pp. 65-78, 1994.
 O. S. Mian, J. M. Thom, L. P. Ardigò, M. V. Narici, and A. E. Minetti, "Metabolic cost, mechanical work, and efficiency during walking in young and older men," Acta physiologica, Vol. 186, pp. 127-139, 2006.
 J. D. Ortega and C. T. Farley, "Individual limb work does not explain the greater metabolic cost of walking in elderly adults," Journal of Applied Physiology, Vol. 102, pp. 2266-2273, 2007.
 J. S. Woo, C. Derleth, J. R. Stratton, and W. C. Levy, "The influence of age, gender, and training on exercise efficiency," Journal of the American College of Cardiology, Vol. 47, pp. 1049-1057, 2006.
 T. Ogawa, R. J. Spina, W. r. Martin, W. M. Kohrt, K. Schechtman, J. Holloszy, et al., "Effects of aging, sex, and physical training on cardiovascular responses to exercise," Circulation, Vol. 86, pp. 494-503, 1992.
 E. Schrödinger, What is life?: the physical aspect of the living cell; based on lectures delivered under the auspices of the Inst. at Trinity College, Dublin, in Feb. 1943. Cambridge: Cambridge University Press, 1944.
 O. Toussaint, C. Michiels, M. Raes, and J. Remacle, "Cellular aging and the importance of energetic factors," Experimental Gerontology, Vol. 30, pp. 1-22, 1995.
 H. Guiney and L. Machado, "Benefits of regular aerobic exercise for executive functioning in healthy populations," Psychonomic bulletin & review, Vol. 20, pp. 73-86, 2013.
 P. A. Figueiredo, M. P. Mota, H. J. Appell, and J. A. Duarte, "The role of mitochondria in aging of skeletal muscle," Biogerontology, Vol. 9, pp. 67-84, 2008.
 C. B. Cairns, J. Walther, A. H. Harken, and A. Banerjee, "Mitochondrial oxidative phosphorylation thermodynamic efficiencies reflect physiological organ roles," American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 274, pp. R1376-R1383, 1998.
 A. J. Santanasto, N. W. Glynn, S. A. Jubrias, K. E. Conley, R. M. Boudreau, F. Amati, et al., "Skeletal muscle mitochondrial function and fatigability in older adults," The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Vol. 70, pp. 1379-1385, 2015.