Commenced in January 2007
Paper Count: 30101
Immunohistochemical Expression of β-catenin and Epidermal Growth Factor Receptor in Adamantinomatous Craniopharyngioma
Abstract:Introduction: Craniopharyngiomas (CPs) are rare epithelial tumors located mainly in the sellar/parasellar region. CPs have been classified histopathologically, genetically, clinically and prognostically into two distinctive subtypes: adamantinomatous and papillary variants. Aim: To examine the pattern of expression of both the β-catenin and epidermal growth factor receptor (EGFR) in surgically resected samples of adamantinomatous CP, and to asses for the possibility of using anti-EGFR in the management of ACP patients. Materials and methods: β-catenin and EGFR immunostaining was performed on paraffin-embedded tissue sections of 18 ACP cases. Result: 17 out of 18 cases (94%) of ACP exhibited strong nuclear/cytoplasmic expression of β-catenin, 15 (83%) of APC cases were positive for EGFR. Conclusion: Nuclear accumulation of β-catenin is a diagnostic hallmark of ACP. EGFR positivity in most cases of ACP could qualify the use of anti-EGFR therapy.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1124577Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1396
 S.T. Qi, J. Zhou, J. Pan, C. Zhang, C. Silky, X.R. Yan Epithelial– mesenchymal transition and clinicopathological correlation in craniopharyngioma Histopathology, 61 (4) (2012), pp. 711–725.
 J.P. Martinez-Barbera. Biology of human craniopharyngioma: lessons from mouse models. J Endocrinol (2015)
 S. Puget, M. Garnett, A. Wray, J. Grill, J.L. Habrand, N. Bodaert, M. Zerah, M. Bezerra, D. Renier, A. Pierre-Kahn, et al. Pediatric craniopharyngiomas: classification and treatment according to the degree of hypothalamic involvement. J Neurosurg, 106 (1 Suppl.) (2007), pp. 3–12
 Grover WD, Rorke LB. Invasive craniopharyngioma. Journal of neurology, neurosurgery, and psychiatry. 1968;31(6):580-2.
 Van Effenterre R, Boch AL. Craniopharyngioma in adults and children: a study of 122 surgical cases. Journal of neurosurgery. 2002;97(1):3-11.
 Larkin, S. J., & Ansorge, O. (2012). Pathology and pathogenesis of craniopharyngiomas. Pituitary, 16(1), 9-17.
 Prabhu, V. C., & Brown, H. G. (2005). The pathogenesis of craniopharyngiomas. Child's Nervous System, 21(8), 622-627.
 Weiner HL, Wisoff JH, Rosenberg ME, Kupersmith MJ, Cohen H, Zagzag D, et al. Craniopharyngiomas: a clinicopathological analysis of factors predictive of recurrence and functional outcome. Neurosurgery. 1994;35(6):1001-10; discussion 10-1.
 Duff J, Meyer FB, Ilstrup DM, Laws ER, Jr., Schleck CD, Scheithauer BW. Long-term outcomes for surgically resected craniopharyngiomas. Neurosurgery. 2000;46(2):291-302; discussion -5.
 Gabriel Zada, Ning Lin, Eric Ojerholm, Shakti Ramkissoon, & Edward R. Laws. (2010). Craniopharyngioma and other cystic epithelial lesions of the sellar region: a review of clinical, imaging, and histopathological relationships. Neurosurgical Focus, 28(4), E4.
 Roskoski R, Jr. The ErbB/HER receptor protein-tyrosine kinases and cancer. Biochemical and biophysical research communications. 2004;319(1):1-11.
 Herbst RS. Review of epidermal growth factor receptor biology. International journal of radiation oncology, biology, physics. 2004;59(2 Suppl):21-6.
 Yu WH, Woessner JF, Jr., McNeish JD, Stamenkovic I. CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling. Genes & development. 2002;16(3):307-23.
 Lee CH, Hung HW, Hung PH, Shieh YS. Epidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancer. Molecular cancer. 2010;9:64.
 Civenni G, Holbro T, Hynes NE. Wnt1 and Wnt5a induce cyclin D1 expression through ErbB1 transactivation in HC11 mammary epithelial cells. EMBO reports. 2003;4(2):166-71.
 Lu Z, Ghosh S, Wang Z, Hunter T. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion. Cancer cell. 2003;4(6):499-515.
 Schroeder JA, Adriance MC, McConnell EJ, Thompson MC, Pockaj B, Gendler SJ. ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)- Wnt-1 and MMTV-c-Neu transgenic carcinomas. The Journal of biological chemistry. 2002;277(25):22692-8.
 D. Atkins, K.A. Reiffen, C.L. Tegtmeier, H. Winther, M.S. Bonato, S. Storkel. Immunohistochemical detection of EGFR in paraffin-embedded tumor tissues: variation in staining intensity due to choice of fixative and storage time of tissue sections. J Histochem Cytochem, 52 (7) (2004), pp. 893–901
 Keisuke Kato. "Possible linkage between specific histological structures and aberrant reactivation of the Wnt pathway in adamantinomatous craniopharyngioma", The Journal of Pathology, 07/2004
 Buslei R, Nolde M, Hofmann B, Meissner S, Eyupoglu IY, Siebzehnrubl F, et al. Common mutations of beta-catenin in adamantinomatous craniopharyngiomas but not in other tumours originating from the sellar region. Acta neuropathologica. 2005;109(6):589-97.
 Annett Hölsken, Department of Neuropathology, University Hospital Erlangen, Schwabachanlage. EGFR Signaling Regulates Tumor Cell Migration in Craniopharyngiomas.