@article{(Open Science Index):https://publications.waset.org/pdf/10004566,
	  title     = {Immunohistochemical Expression of β-catenin and Epidermal Growth Factor Receptor in Adamantinomatous Craniopharyngioma },
	  author    = {Ghada Esheba and  Fatimah Alturkistani and  Arwa Obaid and  Ahdab Bashehab and  Moayad Alturkistani },
	  country	= {},
	  institution	= {},
	  abstract     = {Introduction: Craniopharyngiomas (CPs) are rare epithelial tumors located mainly in the sellar/parasellar region. CPs have been classified histopathologically, genetically, clinically and prognostically into two distinctive subtypes: adamantinomatous and papillary variants. Aim: To examine the pattern of expression of both the β-catenin and epidermal growth factor receptor (EGFR) in surgically resected samples of adamantinomatous CP, and to asses for the possibility of using anti-EGFR in the management of ACP patients. Materials and methods: β-catenin and EGFR immunostaining was performed on paraffin-embedded tissue sections of 18 ACP cases. Result: 17 out of 18 cases (94%) of ACP exhibited strong nuclear/cytoplasmic expression of β-catenin, 15 (83%) of APC cases were positive for EGFR. Conclusion: Nuclear accumulation of β-catenin is a diagnostic hallmark of ACP. EGFR positivity in most cases of ACP could qualify the use of anti-EGFR therapy. },
	    journal   = {International Journal of Biomedical and Biological Engineering},
	  volume    = {9},
	  number    = {12},
	  year      = {2015},
	  pages     = {1304 - 1307},
	  ee        = {https://publications.waset.org/pdf/10004566},
	  url   	= {https://publications.waset.org/vol/108},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 108, 2015},
	}