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A Comparative CFD Study on the Hemodynamics of Flow through an Idealized Symmetric and Asymmetric Stenosed Arteries

Authors: B. Prashantha, S. Anish


The aim of the present study is to computationally evaluate the hemodynamic factors which affect the formation of atherosclerosis and plaque rupture in the human artery. An increase of atherosclerosis disease in the artery causes geometry changes, which results in hemodynamic changes such as flow separation, reattachment, and adhesion of new cells (chemotactic) in the artery. Hence, geometry plays an important role in the determining the nature of hemodynamic patterns. Influence of stenosis in the non-bifurcating artery, under pulsatile flow condition, has been studied on an idealized geometry. Analysis of flow through symmetric and asymmetric stenosis in the artery revealed the significance of oscillating shear index (OSI), flow separation, low WSS zones and secondary flow patterns on plaque formation. The observed characteristic of flow in the post-stenotic region highlight the importance of plaque eccentricity on the formation of secondary stenosis on the arterial wall.

Keywords: Atherosclerotic plaque, Oscillatory Shear Index, Stenosis nature, Wall Shear Stress.

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[1] R. Beaglehole, A. Irwin, and T. Prentice, “Facts and Figures: The World Health Report 2003—Shaping the Future,” World Health Organization, Tech. Rep.
[2] P. Constantinides, “Atherosclerosis–A General Survey and Synthesis”. Pathology and Immunopathology Research, vol. 3(6), 1984, pp. 477-498.
[3] I. Marshall, S. Zhao, P. Papathanasopoulou, P. Hoskins, X. Y. Xu, “MRI and CFD studies of pulsatile flow in healthy and stenosed carotid bifurcation models”. Journal of Biomechanics, vol. 37, 2004, pp. 679-687.
[4] D. Tang, C. Yang, J. Zheng, P. K. Woodard, J. E. Saffitz, G. A. Sicard, & C. Yuan, “Quantifying effects of plaque structure and material properties on stress distributions in human atherosclerotic plaques using 3D FSI models”, Journal of biomechanical engineering, vol. 127, 2005, pp. 1185-1194.
[5] A. Razavi, E. Shirani, M. R Sadeghi, “Numerical simulation of blood pulsatile flow in a stenosed carotid artery using different rheological models”, Journal of Biomechanics, vol. 14, 2011, pp. 2021-2030.
[6] J. Banks, N. W. Bressloff, “Turbulence modelling in three-dimensional stenosed arterial bifurcations”, Journal of biomechanical engineering, vol. 129, 2007, pp. 40-50.
[7] J. R. Buchanan, C. Kleinstreuer, and J. K. Comer, “Rheological effects on pulsatile hemodynamics in a stenosed tube,” Computers and Fluids, vol. 29, no. 6, 2000, pp. 695–724.
[8] S. A. Ahmed, D. P. Giddens, “Pulsatile post stenotic flow studies with laser Doppler anemometry”, Journal of biomechanics, vol. 17, 1984, pp. 695-705.