Effect of Different Model Drugs on the Properties of Model Membranes from Fishes

Authors: M. Kumpugdee-Vollrath, T. G. D. Phu, M. Helmis

Abstract:

A suitable model membrane to study the pharmacological effect of pharmaceutical products is human stratum corneum because this layer of human skin is the outermost layer and it is an important barrier to be passed through. Other model membranes which were also used are for example skins from pig, mouse, reptile or fish. We are interested in fish skins in this project. The advantages of the fish skins are, that they can be obtained from the supermarket or fish shop. However, the fish skins should be freshly prepared and used directly without storage. In order to understand the effect of different model drugs e.g. lidocaine HCl, resveratrol, paracetamol, ibuprofen, acetyl salicylic acid on the properties of the model membrane from various types of fishes e.g. trout, salmon, cod, plaice permeation tests were performed and differential scanning calorimetry was applied.

Keywords: Fish skin, model membrane, permeation, DSC, lidocaine HCl, resveratrol, paracetamol, ibuprofen, acetyl salicylic acid.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1123616

References:

[1] M. Masson, S.D. Sigfusson, T. Loftsson "Fish Skin as a Model Membrane to Study Transmembrane Drug Delivery with Cyclodextrins", Journal of Inclusion Phenomena and Macrocyclic Chemistry, vol. 44, issue 1-4, pp 177-182, 2002.
[2] F. Konradsdottir, T. Loftsson, S. D. Sigfusson "Fish skin as a model membrane: structure and characteristics", Journal of Pharmacy and Pharmacology, vol. 61, issue 1, pp 121-124, 2009.
[3] M. Kumpugdee-Vollrath "Determination of secondary nanostructure of model membrane from local fishes for application in pharmaceutical field", Acta Physica Polonica A, accepted for 2015.
[4] M. Kumpugdee-Vollrath, T. Subongkot, T. Ngawhirunpat "Model Membrane from Shed Snake Skins", World Academy of Science, Engineering and Technology, vol. 82, pp 1140-1147, 2013.
[5] N. Wonglertnirant, T. Ngawhirunpat, M. Kumpugdee-Vollrath "Evaluation of skin enhancing mechanism of surfactants on the biomembrane from shed snake skin", Biological & Pharmaceutical Bulletin, vol. 35, issue 4, pp 1-9, 2012.