Gel-Based Autologous Chondrocyte Implantation (GACI) in the Knee: Multicentric Short Term Study
Autologous Chondrocyte Implantation (ACI) is used worldwide since 1998 to treat cartilage defect. GEL based ACI is a new tissue-engineering technique to treat full thickness cartilage defect with fibrin and thrombin as scaffold for chondrocytes. Purpose of this study is to see safety and efficacy of gel based ACI for knee cartilage defect in multiple centres with different surgeons. Gel-based Autologous Chondrocyte Implantation (GACI) has shown effectiveness in treating isolated cartilage defect of knee joint. Long term results are still needed to be studied. This study was followed-up up to two years and showed benefit to patients. All enrolled patients with a mean age of 28.5 years had an average defect size of3 square centimeters, and were grade IV as per ICRS grading. All patients were followed up several times and at several intervals at 6th week, 8th week, 11th week, 17th week, 29th week, 57th week after surgery. The outcomes were measured based on the IKDC (subjective and objective) and MOCART scores.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1338832Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1370
 Messner K, Maletius W (1996) The long-term prognosis for severe damage to weight-bearing cartilage in the knee: a 14-year clinical and radiographic follow-up in 28 young athletes. ActaOrthopScand 67:165–168.
 Gilbert JE (1998) Current treatment options for the restoration of articular cartilage. Am J Knee Surg 11:42–46.
 Brittberg M (1999) Autologous chondrocyte transplantation. ClinOrthopRelat Res 367(Suppl): S147–S155.
 Erggelet C, Sittinger M, Lahm A (2003) The arthroscopic implantation of autologous chondrocytes for the treatment of full thickness cartilage defects of the knee joint. J Arthroscopy 19:108–110
 Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L (1994) Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 331:889–895.
 Henderson IJ, Tuy B, Connell D, Oakes B, Hettwer WH (2003) Prospective clinical study of autologous chondrocyte implantation and correlation with MRI at three and 12 months. J Bone Joint Surg Br 85:1060–1066.
 Hendrickson DA, Nixon AJ, Grande DA et al (1994) Chondrocyte-fibrin matrix transplants for resurfacing extensive articular cartilage defects. J Orthop Res 12:485–497.
 Kirilak Y, Pavlos NJ, Willers CR et al (2006) Fibrin sealant promotes migration and proliferation of human articular chondrocytes: possible involvement of thrombin and protease-activated receptors. Int J Mol Med 17:551–558.
 Marlovits S, Hombauer M, Truppe M, Vecsei V, Schlegel W(2004) Changes in the ratio of type-I and type-II collagen expression during monolayer culture of human chondrocytes. J Bone Joint Surg Br 86:286–295.
 Micheli LJ, Browne JE, Erggelet C et al (2001) Autologous chondrocyte implantation of the knee: multicenter experience and minimum 3-year follow-up. Clin J Sport Med 11:223–228.
 Minas T, Peterson L (1999) Advanced techniques in autologous chondrocyte transplantation. Clin Sports Med 18:13– 44.
 Itay S, Abramovici A, Nevo Z (1987) Use of cultured embryonal chick epiphyseal chondrocytes as grafts for defects in chick articular cartilage. ClinOrthopRelat Res 220:284–303.
 Munirah S, Samsudin OC, Chen HC, Salmah SH, Aminuddin BS, Ruszymah BH (2007) Articular cartilage restoration in loadbearing osteochondral defects by implantation of autologous chondrocyte-fibrin constructs: an experimental study in sheep. J Bone Joint Surg Br 89:1099–1109.
 Peterson L, Brittberg M, Kiviranta I, Akerlund EL, Lindahl A (2002) Autologous chondrocyte transplantation. Biomechanics and long-term durability. Am J Sports Med 30:2–12.
 Peterson L, Minas T, Brittberg M, Nilsson A, Sjogren-Jansson E, Lindahl A (2000) Two-to 9-year outcome after autologous chondrocyte transplantation of the knee. ClinOrthopRelat Res 374:212–234.
 Myung Ku Kim, Sungwook Choi, Sanag Rim Kim, In Suk Oh, Man Hee Won (2009) Autologous Chonfrocyte Implantation in the Knee Using Fibrin. Knee Surgery Sports Traumatology Arthroscopy 09/2009; 18(4): 528-34.
 Nam-Yong Choi et al (2010) Gel-type autologous chondrocyte implantation for treatment of articular defects of the knee. BMC Musculoskelet Disord 2010; 11-103
 Tegner Y, Lysholm J (1985) Rating systems in the evaluation of knee ligament injuries. ClinOrthopRelat Res 198:43– 49.
 Wakitani S, Kimura T, Hirooka A et al (1989) Repair of rabbit articular surfaces with allograft chondrocytes embedded in collagen gel. J Bone Joint Surg Br 71:74–80 Knee Surg Sports TraumatolArthrosc.