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Determination of Myocardial Function Using Heart Accumulated Radiopharmaceuticals

Authors: C. C. D. Kulathilake, M. Jayatilake, T. Takahashi


The myocardium is composed of specialized muscle which relies mainly on fatty acid and sugar metabolism and it is widely contribute to the heart functioning. The changes of the cardiac energy-producing system during heart failure have been proved using autoradiography techniques. This study focused on evaluating sugar and fatty acid metabolism in myocardium as cardiac energy getting system using heart-accumulated radiopharmaceuticals. Two sets of autoradiographs of heart cross sections of Lewis male rats were analyzed and the time- accumulation curve obtained with use of the MATLAB image processing software to evaluate fatty acid and sugar metabolic functions.

Keywords: fatty acid, autoradiographs, radiopharmaceuticals and sugar

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