Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 33093
Screening of Potential Sources of Tannin and Its Therapeutic Application
Authors: Mamta Kumari, Shashi Jain
Abstract:
Tannins are a unique category of plant phytochemicals especially in terms of their vast potential health-benefiting properties. Researchers have described the capacity of tannins to enhance glucose uptake and inhibit adipogenesis, thus being potential drugs for the treatment of non-insulin dependent diabetes mellitus. Thus, the present research was conducted to find out tannin content of food products. The percentage of tannin in various analyzed sources ranged from 0.0 to 108.53%; highest in kathaa and lowest in ker and mango bark. The percentage of tannins present in the plants, however, varies. Numerous studies have confirmed that the naturally occurring polyphenols are key factor for the beneficial effects of the herbal medicines. Isolation and identification of active constituents from plants, preparation of standardized dose & dosage regimen can play a significant role in improving the hypoglycaemic action.Keywords: Tannins, Diabetes, Polyphenols, Antioxidants, Hypoglycemia.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1109225
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2312References:
[1] J.P. Spencer, M.M. Abd El Mohsen, A.M. Minihane, and J.C. Mathers, “Biomarkers of the intake of dietary polyphenols: Strengths, limitations and application in nutrition research”, Br J Nutr, vol. 99, 2008, pp.12- 22.
[2] C.H. Beckman, “Phenolic-storing cells: keys to programmed cell death and periderm formation in wilt disease resistance and in general defence responses in plants”, Physiol Mol Plant Pathol, vol. 57, 2000, pp. 101- 10.
[3] C. Manach, A. Scalbert, C. Morand, C. Rémésy, and L. Jimenez, “Polyphenols: food sources and bioavailability”, Am J Clin Nutr, vol.79, 2004, pp. 727-47.
[4] Y. Kashiwada, L. Huang, R.E. Kilkuskie, A.J. Bodner, and K.H. Lee, “Anti-AIDS agents 5. New hexahydroxydiphenyl derivatives as potent inhibitors of HIV replication in H9 lymphocytes”, Bioorg Med Chem Lett, vol. 2, 1992, pp.235-238.
[5] K. Khanbabaee, and T. Van Ree, “Tannins: Classification and definition”, Nat Prod Rep, vol. 18, 2001, pp. 641-649.
[6] A. Bennick, “Interaction of plant polyphenols with salivary proteins”, Crit Rev Oral Biol Med, vol. 13, 2002, pp. 184-196.
[7] The international Pharmacopoeia, World Health Organization, 3rd ed., vol. 5, Geneva, 2003.
[8] AOAC, Official Method, Spectrophotometric Method, 1965.
[9] G.R. Beecher, “Phytonutrients’ role in metabolism: effects on resistance to degenerative processes”, Nutr Rev, vol. 9 (Part II), 1999, pp. S3-S6.
[10] E. Hines, “New nutritive substances: beyond the ABCs”, Food Quality, vol. 6, 1999, pp. 39-43.
[11] M. Rhodes and K.R. Price, Phytochemicals: classification and occurrence, In: Encyclopedia of Human Nutrition, Academic Press/Harcourt Brace & Company Publishers New York, NY, 1999, pp. 1539-1549.
[12] http://ayurvedicmedicinalplants.com
[13] M. Pinent, M. Blay, M.L. Blade, M.J. Salvado, L. Arola, and A. Ardevol, “Grape seed derived procyanidins have an antihyperglycemic effect in Streptozotocin induced Diabetic rats and insulinmimetic activity in insulin sensitive cell lines”, Endocrinology, vol. 145, no.1, 2004, pp. 4985-4990.
[14] M. Shimizu, K. Kobayashi, M. Suzuki, H. Satsu, and Y. Miyamoto, “Regulation of intestinal glucose transport by tea catechins”, Biofactor, vol.13, 2000, pp. 61-65.
[15] T.H. Terril, A.M. Rowan, G.B. Douglas, and T.N. Barry, “Determination of extractable and bound condensed tannin concentrations in forage plants, protein concentrate meals and cereal grains”, J Sci Food Agric, vol. 58 1992, pp. 321-329.
[16] P.J. Van Soest, Nutritional ecology of the ruminant, 2nd Ed. Cornell Univ Press, Ithaca, NY, USA, 1994, pp.476
[17] M.C. Alvarez Del Pino, P. Frutos, G. Hervás, A. Gómez, F.J. Giráldez, and A.R. Mantecón, “Efecto del contenido de taninos en la degradación ruminal in vitro de varios órganos de especies arbustivas”, ITEA, Prod Anim, vol. 22, 2001, pp. 355-357.
[18] D.F. Rhoades, Evolution of plant chemical defense against herbivores. In: Herbivores: their interactions with secondary plant metabolites (Rosenthal G.A. and Janzen D.H., eds.), Academic Press, NY, USA, 1979, pp. 3-54.
[19] L. Bravo, “Polyphenols: chemistry, dietary sources, metabolism and nutritional significance”, Nutrition Reviews, vol. 56, 1998, pp. 317-333.
[20] H. Schroeter, C. Boyd, J.P. Spencer, R.J. Williams, E. Cadenas, and C. Rice-Evans, “MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide”, Neurobiol Aging, vol. 23, 2002, pp. 861- 880.
[21] J.P. Spencer, C. Rice-Evans, and R.J. Williams, “Modulation of prosurvival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability”, J Biol Chem, vol. 278, 2003, pp.34783-34793.
[22] G. Agullo, L. Gamet-Payrastre, S. Manenti, C. Viala, C. Rémésy, H. Chap, and B. Payrastre, “Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition”, Biochem Pharmacol,, vol. 53, 1997, pp. 1649-1657.
[23] C.J. Vlahos, W.F. Matter, K.Y. Hui, and R.F. Brown, “A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl- 4H-1-benzopyran-4-one (LY294002)”, J Biol Chem, vol. 269, 1994, pp. 5241-5248.
[24] L. Gamet-Payrastre, S. Manenti, M.P. Gratacap, J. Tulliez, H. Chap, and B. Payrastre, “Flavonoids and the inhibition of PKC and PI 3-kinase”, Gen Pharmacol, vol. 32, 1999, pp. 279-286.
[25] R.J. Williams, J.P. Spencer, and C. Rice-Evans, “Flavonoids: antioxidants or signaling molecules”, Free Radic Biol Med, vol. 36, 2004, pp. 838-849.
[26] K.E. Heim, A.R. Tagliaferro, and D.J. Bobilya, “Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships”, J Nutr Biochem, vol. 13, 2002, pp. 572-584.