Contrast-Enhanced Magnetic Resonance Angiography in Rats with Gadobenate Dimeglumine at 3T

Authors: Jo-Chi Jao, Yen-Ku Chen, Twei-Shiun Jaw, Po-Chou Chen

Abstract:

This study aimed to investigate the magnetic resonance (MR) signal enhancement ratio (ER) of contrast-enhanced MR angiography (CE-MRA) in normal rats with gadobenate dimeglumine (Gd-BOPTA) using a clinical 3T scanner and an extremity coil. The relaxivities of Gd-BOPTA with saline only and with 4.5% human serum albumin (HSA) were also measured. Compared with Gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA), Gd-BOPTA had higher relaxivities. The maximum ER of aorta (ERa), kidney, liver and muscle with Gd-BOPTA were higher than those with Gd-DTPA. The maximum ERa appeared at 1.2 min and decayed to half at 10 min after Gd-BOPTA injection. This information is helpful for the design of CE-MRA study of rats.

Keywords: Contrast-Enhanced Magnetic Resonance Angiography, Gd-BOPTA, Gd-DTPA, Rat.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1106881

References:

[1] A. Levent, I. Yuce, S. Eren, O. Ozyigit, and M. Kantarci, “Contrast-Enhanced and Time-of-Flight MR Angiographic Assessment of Endovascular Coiled Intracranial Aneurysms at 1.5 T,” Interv Neuroradiol., vol. 20, pp. 686-92, Dec 2014.
[2] S. Roujol, M. Foppa, T.A. Basha, M. Akçakaya, K.V. Kissinger, B. Goddu, S. Berg, and R. Nezafat, “Accelerated free breathing ECG triggered contrast enhanced pulmonary vein magnetic resonance angiography using compressed sensing,” J Cardiovasc Magn Reson., vol. 16, pp. 91, Nov 2014.
[3] S. Mavrogeni, G. Markousis-Mavrogenis, and G. Kolovou, “Contribution of cardiovascular magnetic resonance in the evaluation of coronary arteries,” World J Cardiol., vol. 6, pp. 1060-6, Oct 2014.
[4] X. Mu, H. Wang, Q. Ma, C. Wu, and L. Ma, “Contrast-enhanced magnetic resonance angiography for the preoperative evaluation of hepatic vascular anatomy in living liver donors: a meta-analysis,” Acad Radiol., vol. 21, pp. 743-9, Jun 2014.
[5] A. M. Saindane, S. R. Boddu, F. C. Tong, S. Dehkharghani, and J. E. Dion, “Contrast-enhanced time-resolved MRA for pre-angiographic evaluation of suspected spinal dural arterial venous fistulas,” J Neurointerv Surg., vol. 7, pp. 135-40, Feb. 2015.
[6] H. P. Niendorf, J. C. Dinger, J. Haustein, I. Cornelius, A. Alhassan, W. Clauss, “Tolerance data of Gd-DTPA: a review,”Eur J Radiol., Vol. 13, pp. 15-21, Jul-Aug 1991.
[7] M. A. Kirchin, G. P. Pirovano, A. Spinazzi, “Gadobenatedimeglumine (Gd-BOPTA). An overview,” Invest Radiol., Vol. 33, pp. 798-809, Nov. 1998.
[8] K. Yoshikawa, Y. Inoue, M. Shimada, M. Akahane, S. Itoh, A. Seno, S. Hayashi., “Contrast-enhanced MRangiography in rats with hepatobiliary contrast agents,”Magn Reson Imaging., Vol. 22, pp. 937-42, Sep. 2004.
[9] E. M. Haacke, R. W. Brwon, M. R. Thompson, R. Venkatesan, Magnetic Resonance Imaging: Physical Principles and Sequence Design, New York, NY: John Wiley and Sons Inc, 1999, pp. 128.
[10] J. C. Jao, H.C. Lu, H. Y. Lu, Y. M. Wang, G.C. Liu, L. M. Lin, P. Y. Chu, S..H. Chen, P. C. Chen, “The Imaging Behavior of an MRI Contrast Agent (Gd(TTDA-BOM)2- in a Mice Liver Model at 3 Tesla,” J Med Biol Eng., Vol. 30, pp. 139-144, Jun 2010.
[11] X. Xing, X. Zeng, X. Li, Q. Zhao, M.A. Kirchin, G. Pirovano, X. Wang, Y. Li, R. Iezzi, and F. De Cobelli, “Contrast-enhanced MR angiography: does a higher relaxivity MR contrast agent permit a reduction of the dose administered for routine vascular imaging applications?,”Radiol Med., vol. 120, pp. 239-50, Feb 2015.
[12] K.L. Nguyen, S.N. Khan, J.M. Moriarty, K. Mohajer, P. Renella, G. Satou, I. Ayad, S. Patel, M.I. Boechat, and J.P. Finn, “High-field MR imaging in pediatric congenital heart disease: initial results,” PediatrRadiol., vol. 45(1), pp. 42-54, Jan 2015.
[13] S. Gaddikeri, L. Mitsumori, S. Vaidya, D.S. Hippe, P. Bhargava, and M.K. Dighe, “Comparing the diagnostic accuracy of contrast-enhanced computed tomographic angiography and gadolinium-enhancedmagnetic resonance angiography for the assessment of hemodynamically significant transplant renal artery stenosis,” CurrProblDiagnRadiol., vol. 43, pp. 162-8, Jul. 2014.