Chloroform-Formic Acid Solvent Systems for Nanofibrous Polycaprolactone Webs
In this study, polycaprolactone (PCL) was dissolved in chloroform:ethanol solvent system at a concentration of 18 w/v %. 1, 2, 4, and 6 droplets of formic acid were added to the prepared 10ml PCL-chloroform:ethanol solutions separately. Fibrous webs were produced by electrospinning technique based on the horizontal working principle. Morphology of the webs was investigated by using scanning electron microscopy (SEM) whereas fiber diameters were measured by Image J Software System. The effect of formic acid addition to the mostly used chloroform solvent on fiber morphology was examined. Results indicate that there is a distinct fall in fiber diameter with the addition of formic acid drops. The average fiber diameter was measured as 2.22μm in PCL /chloroform:ethanol solution system. On the other hand, 328nm and 256 nm average fiber diameters were measured for the samples of 4 drops and 6 drops formic acid added. This study offers alternative solvent systems to produce nanoscaled, nontoxic PCL fibrous webs by electrospinning technique.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1100577Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2427
 C. Y. Xu, R. Inai, M. Kotaki, S. Ramakrishna, “Aligned biodegradable nanofibrous structure: a potential scaffold for blood vessel engineering” Biomaterialsvol.25, pp. 877–886, 2004.
 L. A. Smith, P. X. Ma, “Nano-fibrous scaffolds for tissue engineering” Colloids Surf B: Biointerfacesvol. 39, pp. 125–131, 2004.
 Z. Ma, M. Kotaki, R. Inai, S. Ramakrishna, “Potential of nanofiber matrix as tissueengineering scaffolds” Tissue Eng, vol.11, pp. 101–119, 2005.
 N. Ashammakhi, A. Ndreu, Y. Yang, H. Ylikauppila, L. Nikkola, “Nanofiber-based scaffolds for tissue engineering” Eur J PlastSurg, 2008.
 X. Zong, S. Ran, K. S. Kim D. Fang, B. S. Hsiao, B. Chu, “Structure and Morphology Changes During in Vitro degradation of Electrospun Ploy(glicolide-co-lactide) nanofiber membrane” Biomacromolecules, vol. 4(2), pp. 416-423, 2003.
 S. R. Bhattarai, N. Bhattarai, P. Viswanathamurthi, H. K.Yi, P.H. Hwang, H.Y. Kim, “Hydrofilicnanofibrous structure of polylactide; fabrication and cell affinity” J Biomedical Materials Ress Part A, Vol. 78(2). Pp.247-257, 2006.
 J. Hao, M. Yuan and X. Deng, “Biodegradable and Biocompatible Nanocomposites of Polycaprolactone with hydroxyapatite nanocrystals:thermal and mechanical properties” J ApplPolymSci, vol. 86(3), pp. 663-683, 2002.
 A. G. Kanani, S. H. Bahrami, “Effect of Solvents on PloycaprolactoneNanofibrous Webs Morphology” J Nanomater, vol. 2011, pp. 1-10, 2011.
 L. V. Schueren, B. Schoenmaker, O. I. Kalaoglu, K. Clerck,“An alternative solvent system for the steady state electrospinning of polycaprolactone”, EurPolym J, vol. 47, pp. 1256–1263. 2011.
 L. V. Scueren, B. Schoenmaker, O. I. Kalaoglu, K. Clerk, “An Alternative Solvent System for The Steady State Electrospinning Of Polycaprolactone” EurPolym J vol. 47, pp. 1256-1263, 2011.
 J. L. Lowery, N. Datta,G. C. Rutledge,“Effect of fiber diameter, pore size and seeding method on growth of human dermal fibroblasts in electrospun poly(epsilon-caprolactone) fibrous mats”, Biomaterials, vol. 31(3), pp.491–504, 2010.
 C.Del Gaudio, M. Grigioni, A. Bianco, G. De Angelis “Electrospunbioresorbable heart valve scaffold for tissue engineering”. Int J Artif Organs, vol. 31(1) pp.68–75, 2008.
 I. Yalcin, J. Harakova, P. Mikes, T.GokSadikoglu, R. Domin,D. Lukas, “Design of Polycaprolactone Vascular Grafts” J Ind Text, (online published in June 2014,Available at http://jit.sagepub.com/content/early/2014/06/23/1528083714540701)