Technologies of Amination of Hydroxyanthraquinones

Authors: Dmitry Yu. Korulkin, Raissa A. Muzychkina

Abstract:

In review the generalized data about different methods of synthesis of biological activity aminated hydroxyanthraquinones is presented. The basic regularity of a synthesis is analyzed. Action of temperature, pH, solubility, catalysts and other factors on a reaction product yield is revealed.

Keywords: Amination, hydroxyanthraquinones, nucleophilic exchange, physiologically active substances.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1099732

References:

[1] R. A. Muzychkina, D. Yu. Korulkin, The modified anthraquinones, Almaty: CBB Globus, 2013.
[2] R. A. Muzychkina, Natural Anthraquinones. Biological Properties and Physicochemical Characteristics, Moscow: Phasis, 1998.
[3] N. P. Gritsan, L. S. Klimenko, E. P. Fokin, J. Photochem. Photobiol. A: Chem., vol. 52, pp. 136-156, 1990.
[4] V. A. Loskutov, S. M. Lukonina, E. P. Fokin, J. Org. Chem., vol. 17, no. 3, pp. 584-589, 1981.
[5] N. P. Gritsan, L. S. Klimenko, Z. V. Leonenko, Tetrahedron, vol. 51, no. 10, pp. 3061-3076, 2004.
[6] C. Y. Chen, Y. Lu, Z. N. Chen, Acta Univ. Med. Second. Shanghai, vol. 21, pp. 488-491, 2001.
[7] J. Lokvam, P. D. Coley, T. A. Kursar, Phytochem., vol. 65, no. 3, pp. 351-358, 2004.
[8] A. A. Eleganus, C. Bates, A. I. Gray, Phytochem., vol. 63, no. 6, pp. 727-730, 2003.
[9] I.-L. Huang, P.-I. Ieh, C. C. Shen, C. C. Chen, Phytochem., vol. 64, no. 7, pp. 1277-1279, 2003.
[10] L. Bloomer, J. Org. Chem., vol. 58 no. 27, pp.7906-7912, 1993.
[11] K. Katsuura, Tetrahedron Lett., no. 1, pp. 9-12, 1985.
[12] K. Nakamura, T. Assai, T. Hara, Bull. Chem. Soc. Japan, vol. 56, no. 5, pp. 1435-1439, 1983.
[13] J. V. Bergman, J. Amer. Chem. Soc., vol. 113, no. 18, pp. 6982-6998, 1991
[14] C. H. Chen, C. Y. Shaw, C. C. Chen, Y. C. H. Tsai, J. Nat. Prod., vol. 65, pp. 740-741, 2002.