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Ultrasonographic Manifestations of Periventricular Leukomalacia in Preterm Neonates at Teaching Hospital Peradeniya, Sri Lanka

Authors: P. P. Chandrasekera, P. B. Hewavithana, S. Rosario, M. H. M. N. Hearth, D. M. R. D. Mirihella

Abstract:

Periventricular Leukomalacia (PVL) is a White Matter Injury (WMI) of preterm neonatal brain. Objectives of the study were to assess the neuro-developmental outcome at one year of age and to determine a good protocol of cranial ultrasonography to detect PVL. Two hundred and sixty four preterm neonates were included in the study. Series of cranial ultrasound scans were done by using a dedicated neonatal head probe 4-10 MHz of Logic e portable ultrasound scanner. Clinical history of seizures, abnormal head growth (hydrocephalus or microcephaly) and developmental milestones were assessed and neurological examinations were done until one year of age. Among live neonates, 57% who had cystic PVL (Grades 2 and 3) manifested as cerebral palsy. In conclusion cystic PVL has permanent neurological disabilities like cerebral palsy. Good protocol of real time cranial ultrasonography to detect PVL is to perform scans at least once a week until one month and at term (40 weeks of gestation).

Keywords: Cerebral Palsy, cranial ultrasonography, preterm neonates, Periventricular Leukomalacia (PVL)

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1338020

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References:


[1] M. Carol Rumack , R. Stephanie Wilson, R. William Charbonneau, et al, Diagnostic ultrasound, 4th edition, vol 2, 2011, pp. 1596-1612.
[2] Erik Beek, and Floris Groenendaal, Neonatal brain ultrasound, The Radiology Assistant, April 1 2006.
[3] Kenneth D. Williams, Imaging evaluation of neonatal hypoxic ischemic encephalopathy, SCOTT & WHITE Health care.
[4] Y. Benjamin Huang, and Mauricio Castillo, Hypoxic ischaemic brain injury, imaging findings from birth to adulthood, Radiographics, 2008, vol 28(2), pp. 417-39.
[5] A. James Barkovich, R. Kevin Moore, V. Blaise Jones, Gilbert Vezina, L. Bernadette Kock, Charles Rayband, et al, Diagnostic imaging in pediatric neuroradiology, 2007, First Edition. Chapter 1:1, pp. 132-139.
[6] Joseph J. Volpe, Neurology of the newborn, Fifth edition, 2008, pp. 247- 461, 517-588.
[7] A. Santina, and Zamnelli, Guidelines to assist in the diagnosis of severe hypoxic ischaemic encephalopathy, Medscape, June 2012.
[8] A. Waidermar Cario, Nelson text book of pediatrics, 19th edition, 2011, pp. 566-572, 2059-2065.
[9] S. K. Shinha, S. W. D. Souza, R. Rivlin, and M. A. Chiswick, Ischaemic brain lesions diagnosed at birth in preterm infants, clinical events and developmental outcome, Archives of disease in childhood, July 1996, vol75(1).
[10] Ming Chi Lai, and San Nan Yang, Perinatal hypoxic ischaemic encephalopathy, Journal of Biomedicine and Biotechnology, vol 2011(2011), 6 pages.
[11] Gradner and R. Marcia, Outcomes in children experiencing neurologic insults in preterm neonates, redOrbit, Dec. 18th 2005, vol 31(6), pp. 448, 451-6.
[12] Terence Zach, Ted Rosenkratz, more, Pediatric periventricular leukomalacia, Medscape, update June 18th 2012.
[13] Tom Lissauer, and Graham Clayden, Illustrated textbook of pediatrics, 4th edition, 2012, p.49-66.
[14] Christine, P. Chao, and G. Christopher, Neonatal hypoxic ischaemic encephalopathy, Radiographics, 2013, vol 33(1).
[15] Jun Su, Li Wang, Research advances in neonatal hypoglycemic brain injury, Translational Paediatrics, October 2012.
[16] L. W. Chang, J. Liu ,and W. B. Li, A Preliminary study on diagnosis and grading of hypoxic ischaemic brain damage of preterm infants, Pub Med, Zhongguo Dang Dai ZaZhi, Aug 2007, vol 9(4), pp. 293
[17] Pavithra Logitharajah, A. Mary, Rutherford,and Frances Cowan, Hypoxic ischaemic encephalopathy in preterm infants, antecedent factors, brain imaging and outcome, Pediatric RESEARCH, 2009, vol66, pp. 222-229.
[18] T. Cloherty, A. Stark, and E. Eichenwaid, Manual of neonatal care, 6th edition, 2012, Chapter 54.
[19] Rachel Sidwell, and Mike Thomson, Concise pediatrics, First edition, 2001, pp. 383-384.
[20] Omar Islam, Eugene C. Lin, more, Germinal matrix haemorrhage imaging, Medscape, 2013.