Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 31168
Antimicrobial Potentials of Flavonoids Isolated from Tagetes erecta

Authors: N. Behidj-Benyounes, S. Bennaamane, F. Zohra Bissaad, N. Chebouti, H. Mohandkaci, N. Abdalaziz, S. Iddou


In this study, we are interested in a species of the family of Asteraceae (Tagetes erecta). This family is considered as a source of antimicrobial extracts with strong capacity. The extraction of the flavonoids is carried out by the method of liquid/liquid with the use of successive solvents. Afterwards, we evaluated the biological activity of the flavonoids on five pathogenic bacterial stocks such as Escherichia coli, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa and Staphylococcus aureus and two stocks of yeasts to knowing Candida albicans) and Saccharomyces cerevisiae, by employing the method of the aromatogramme starting from a solid disc. The result of the antimicrobial activity shows an action and a variable degree of sensitivity according to bacterial stocks tested. It will be noted that the flavonoids have an inhibiting effect on E. coli, B. subtilis, K. pneumoniae and S. aureus. But a resistance with respect to the extract by P. aeruginosa, C. albicans and S. cerevisiae is to be mentioned.

Keywords: Antimicrobial activity, Flavonoids, microbial strains, Tagetes erecta L

Digital Object Identifier (DOI):

Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2262


[1] C.Muthu, N.Mir,S.Ignacimuthu, “Medicinal plants used by traditional healers in kanchee puran district of tamil Nado, India”. Journal of ethnobiology and ethnomedecine. 2006; 2, 43 doi: 10.1186/1746-4269- 2-43.
[2] O. Catier, D. Roux, “Botanique, pharmacogonosie, phytothérapeutie” .3rd Wolters Kluwer, 2007. p. 13.
[3] D. Lamnaouer, “Composition chimique et activité biologique de quelques plantes médicinales du PNT”. Programme de l’UICN en Afrique du nord, 2001. Phase III, p. 1-9.
[4] D. Lamnaouer, “Réflexions sur l’enseignement de la botanique et des plantes médicinales”. Colloque « Voyages en Botanique » Maroc; 2010. p.4.
[5] D.S.Teixeira, “Mining the essential oil of the Anthemideae”. African Journal of Biotechnology.v.3, n.12, p. 706-720, 2004.
[6] L Pacheco, M. M. Costantine, G. D. V. Hankins,“Physiologic changes during pregnancy,” in Clincal Pharmacology During Pregnancy ed. Mattison D. R., editor. (San Diego: Academic Press; ) 5–14, 2013.
[7] D.R. Katerere, G. Graziani, K.M. Thembo, N.Z. Nyazema, A. Ritieni, “Antioxidant activity of some African medicinal and dietary leafy African vegetables”. Afr. J. Biotechnol.11:4103- 4108, 2012.
[8] I.Farombi, “Africain indigenous plants with chemotherapeutic potentials and biotechnological approach to the production of bioactive prophylactic agent”. African Journal of Biotechnology. v. 2, n. 12, p. 662-671, 2003.
[9] W.F.Sayed, C.T.Wheeler,“Effect of the flavonoid quercetin on culture and isolation of Frankia from Casuarina root nodules”. Folia Microbiol. v.44, n.1, p. 59-62, 1999.
[10] R.N Sanches, D.A.Garcia Corte, M.S.Schiavini, “An evaluation of antibacterial activities of Psidium guajava (L.)”.Brazilian Archives of Biology and Technology. v.48, n.3, p. 429-436, 2005.
[11] A. Hallimi, “Les plantes médicinales en Algérie”. Ed. Berti, Algérie, 2004. p. 42.
[12] N.Behidj-Benyounes, T.Dahmane, K. Hassak, F.Slimani,“The antibacterial activity of flavonoïds extracted from Crateagus oxyacantha (L.) leaves of bainem (Algeria)”.13thInternational Multidisciplinary Scientific GeoConference SGEM Conference proceedings, June 16-22, 2013Albena (Bulgarie). 2013a. p. 288- 295.
[13] N. Behidj-Benyounes, T. Dahmane, K. Hassak, F.Slimani, “The antibacterial activity of flavonoïds extracted from Crateagus oxyacantha (L.) flowers of Boumerdès (Algeria)”. 13thInternational Multidisciplinary Scientific GeoConference SGEM Conference proceedings. June 16-22, 2013 Albena (Bulgarie). 2013b p. 296- 303.
[14] J. Bruneton, “Plantes toxiques végétaux dangereux pour l’Homme et les animaux”. 2nd. Tec and Doc, Paris, France, 2001. p. 542 - 564.
[15] J.L. Fauchere, J.L. Avril, “Bactériologie générale et médicale”. ed. Ellipses, Paris, France, 2002. p. 365.
[16] M.S. Klaric, I.Kosalec, K.J.Mastelic, E.Pieckova, K.Pepeljna, “Antifungal activity of thyme (Thymus vulgaris L.) essential oil and thymol against mould from damp dwellings”. Letters in Applied Microbiology. v.44, p. 36-42, 2006.
[17] M.A.Pfaller, D.Diekema, M.Mendez, C.Kibbler, P.Erzsebet, S.C.Chang, D.L.Gibbs, V.A.Newell, “The global antifungal surveillance group, Candida guilliermondii, an opportunistic fungal pathogen with decreased susceptibility to fluconazole: Geographic and temporal trends from the ARTEMIS DISK Antifungal Surveillance Program”. Journal Clinical Microbiology. v.44, p. 3551-3556, 2004.
[18] C.Su, X.Zhahg, J.P.Dudey, “Génotyping of Toxiplasma gontii PCRRFLP markers: a high resolution simpal method for identification of parasites”. International Journal of Parasitology. v.36, p. 441-848, 2006.
[19] T.Essawi, M.Srour, “Screening of some Palestinian plants for antibacterial activity”. Journal of Ethnopharm.v. 70, p. 343-349. 2000.
[20] M.C.Marjorie,“Plants products as antimicrobial agents”. Clinical Microbiology Reviews. v.9, p. 564-582, 1999.
[21] B.Shan, Y.Z.Cai, J.D.Brooks, H.Corke, “The in vitro antibacterial activity of dietary spice and medicinal herb extracts”. Journal International of Food Microbiology. v.117, p. 112-119, 2007.
[22] T. Askun, G. Tumen, F. Satil, M.Ates,“In vitro activity of methanol extracts of plants used as spices against Mycobacterium tuberculosis and other bacteria”. Food Chemistry. v. 104, n. 116, p. 289-294, 2009.
[23] D.Horikrrisha, A.V.N.Approo, M.C.Probharkar, “Pharmacological investigation of flavonoid glucoside”. Indian Journal of Pharmacology.v.36, p. 244-250, 2004.
[24] S.Rhama, S.Madhavan,“Antibacterial activity of the flavonoid, patulitrin isolated from the flowers of Tagetes erecta L.”International Journal of Pharm Tech Research. v.3, n.3, p. 1407-1409, 2010.
[25] M.C. Pibiri, “Assainissement microbiologique de l’air et du système de ventilation au moyen d’huile essentielle”.Thèse de Doctorat, Ecole Polytechnique Fédérale de Lausanne, 2006. p. 177.
[26] M.A.Alvarez, N.B.Debattista, NB.Pappano, “Antimicrobial activity and synergism of some substituted flavonoids”. Folia Microbiol. v. 53, n.1, p. 23-28, 2008.
[27] S.Rees, J.B.Harborne, “The role of sesquiterpene lactones and phenolics in the chemical defense of the chicory plant”. Phytochemistry.v.24, p. 2225-2231, 1985.