Commenced in January 2007
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Edition: International
Paper Count: 1

whole exome sequencing Related Publications

1 Accurate HLA Typing at High-Digit Resolution from NGS Data

Authors: Yan Zhang, Yazhi Huang, Jing Yang, Dingge Ying, Vorasuk Shotelersuk, Nattiya Hirankarn, Pak Chung Sham, Yu Lung Lau, Wanling Yang


Human leukocyte antigen (HLA) typing from next generation sequencing (NGS) data has the potential for applications in clinical laboratories and population genetic studies. Here we introduce a novel technique for HLA typing from NGS data based on read-mapping using a comprehensive reference panel containing all known HLA alleles and de novo assembly of the gene-specific short reads. An accurate HLA typing at high-digit resolution was achieved when it was tested on publicly available NGS data, outperforming other newly-developed tools such as HLAminer and PHLAT.

Keywords: whole exome sequencing, human leukocyte antigens, HLA typing, next generation sequencing

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