Search results for: surge signature.
Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 157

Search results for: surge signature.

157 Study of the S-Bend Intake Hammershock Based on Improved Delayed Detached Eddy Simulation

Authors: Qun-Feng Zhang, Pan-Pan Yan, Jun Li, Jun-Qing Lei

Abstract:

Numerical investigation of hammershock propagation in the S-bend intake caused by engine surge has been conducted by using Improved Delayed Detach-Eddy Simulation (IDDES). The effects of surge signatures on hammershock characteristics are obtained. It was shown that once the hammershock is produced, it moves upward to the intake entrance quickly with constant speed, however, the strength of hammershock keeps increasing. Meanwhile, being influenced by the centrifugal force, the hammershock strength on the larger radius side is much larger. Hammershock propagation speed and strength are sensitive to the ramp upgradient of surge signature. A larger ramp up gradient results in higher propagation speed and greater strength. Nevertheless, ramp down profile of surge signature have no obvious effect on the propagation speed and strength of hammershock. Increasing the maximum value of surge signature leads to enhance in the intensity of hammershock, they approximately match quadratic function distribution law.

Keywords: Hammershock, IDDES, S-bend, surge signature.

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156 Industrial Compressor Anti-Surge Computer Control

Authors: Ventzas Dimitrios, Petropoulos George

Abstract:

The paper presents a compressor anti-surge control system, that results in maximizing compressor throughput with pressure standard deviation reduction, increased safety margin between design point and surge limit line and avoiding possible machine surge. Alternative control strategies are presented.

Keywords: Anti-surge, control, compressor, PID control, safety, fault tolerance, start-up, ESD.

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155 Surge Protection of Power Supply used for Automation Devices in Power Distribution System

Authors: Liheng Ying, Guangjiong Sun

Abstract:

The intent of this essay is to evaluate the effectiveness of surge suppressor aimed at power supply used for automation devices in power distribution system which is consist of MOV and T type low-pass filter. Books, journal articles and e-sources related to surge protection of power supply used for automation devices in power distribution system were consulted, and the useful information was organized, analyzed and developed into five parts: characteristics of surge wave, protection against surge wave, impedance characteristics of target, using Matlab to simulate circuit response after 5kV,1.2/50s surge wave and suggestions for surge protection. The results indicate that various types of load situation have great impact on the effectiveness of surge protective device. Therefore, type and parameters of surge protective device need to be carefully selected, and load matching is also vital to be concerned.

Keywords: automation devices in power distribution system, MOV, surge, T type low-pass filter.

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154 Off-Line Signature Recognition Based On Angle Features and GRNN Neural Networks

Authors: Laila Y. Fannas, Ahmed Y. Ben Sasi

Abstract:

This research presents a handwritten signature recognition based on angle feature vector using Artificial Neural Network (ANN). Each signature image will be represented by an Angle vector. The feature vector will constitute the input to the ANN. The collection of signature images will be divided into two sets. One set will be used for training the ANN in a supervised fashion. The other set which is never seen by the ANN will be used for testing. After training, the ANN will be tested for recognition of the signature. When the signature is classified correctly, it is considered correct recognition otherwise it is a failure.

Keywords: Signature Recognition, Artificial Neural Network, Angle Features.

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153 Analysis of Lightning Surge Condition Effect on Surge Arrester in Electrical Power System by using ATP/EMTP Program

Authors: N. Mungkung, S. Wongcharoen., Tanes Tanitteerapan, C. Saejao, D. Arunyasot

Abstract:

The condition of lightning surge causes the traveling waves and the temporary increase in voltage in the transmission line system. Lightning is the most harmful for destroying the transmission line and setting devices so it is necessary to study and analyze the temporary increase in voltage for designing and setting the surge arrester. This analysis describes the figure of the lightning wave in transmission line with 115 kV voltage level in Thailand by using ATP/EMTP program to create the model of the transmission line and lightning surge. Because of the limit of this program, it must be calculated for the geometry of the transmission line and surge parameter and calculation in the manual book for the closest value of the parameter. On the other hand, for the effects on surge protector when the lightning comes, the surge arrester model must be right and standardized as metropolitan electrical authority's standard. The candidate compared the real information to the result from calculation, also. The results of the analysis show that the temporary increase in voltage value will be rise to 326.59 kV at the line which is done by lightning when the surge arrester is not set in the system. On the other hand, the temporary increase in voltage value will be 182.83 kV at the line which is done by lightning when the surge arrester is set in the system and the period of the traveling wave is reduced, also. The distance for setting the surge arrester must be as near to the transformer as possible. Moreover, it is necessary to know the right distance for setting the surge arrester and the size of the surge arrester for preventing the temporary increase in voltage, effectively.

Keywords: Lightning surge, surge arrester, electrical power system, ATP/EMTP program.

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152 Proposed Developments of Elliptic Curve Digital Signature Algorithm

Authors: Sattar B. Sadkhan, Najlae Falah Hameed

Abstract:

The Elliptic Curve Digital Signature Algorithm (ECDSA) is the elliptic curve analogue of DSA, where it is a digital signature scheme designed to provide a digital signature based on a secret number known only to the signer and also on the actual message being signed. These digital signatures are considered the digital counterparts to handwritten signatures, and are the basis for validating the authenticity of a connection. The security of these schemes results from the infeasibility to compute the signature without the private key. In this paper we introduce a proposed to development the original ECDSA with more complexity.

Keywords: Elliptic Curve Digital Signature Algorithm, DSA.

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151 Efficient Aggregate Signature Algorithm and Its Application in MANET

Authors: Daxing Wang, Jikai Teng

Abstract:

An aggregate signature scheme can aggregate n signatures on n distinct messages from n distinct signers into a single signature. Thus, n verification equations can be reduced to one. So the aggregate signature adapts to Mobile Ad hoc Network (MANET). In this paper, we propose an efficient ID-based aggregate signature scheme with constant pairing computations. Compared with the existing ID-based aggregate signature scheme, this scheme greatly improves the efficiency of signature communication and verification. In addition, in this work, we apply our ID-based aggregate sig- nature to authenticated routing protocol to present a secure routing scheme. Our scheme not only provides sound authentication and a secure routing protocol in ad hoc networks, but also meets the nature of MANET.

Keywords: Identity-based cryptography, Aggregate signature, Bilinear pairings, Authenticated routing scheme.

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150 Offline Signature Recognition using Radon Transform

Authors: M.Radmehr, S.M.Anisheh, I.Yousefian

Abstract:

In this work a new offline signature recognition system based on Radon Transform, Fractal Dimension (FD) and Support Vector Machine (SVM) is presented. In the first step, projections of original signatures along four specified directions have been performed using radon transform. Then, FDs of four obtained vectors are calculated to construct a feature vector for each signature. These vectors are then fed into SVM classifier for recognition of signatures. In order to evaluate the effectiveness of the system several experiments are carried out. Offline signature database from signature verification competition (SVC) 2004 is used during all of the tests. Experimental result indicates that the proposed method achieved high accuracy rate in signature recognition.

Keywords: Fractal Dimension, Offline Signature Recognition, Radon Transform, Support Vector Machine

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149 A New Proxy Signature Scheme As Secure As ElGamal Signature

Authors: Song Han, Elizabeth Chang, Jie Wang, Wanquan Liu

Abstract:

Proxy signature helps the proxy signer to sign messages on behalf of the original signer. It is very useful when the original signer (e.g. the president of a company) is not available to sign a specific document. If the original signer can not forge valid proxy signatures through impersonating the proxy signer, it will be robust in a virtual environment; thus the original signer can not shift any illegal action initiated by herself to the proxy signer. In this paper, we propose a new proxy signature scheme. The new scheme can prevent the original signer from impersonating the proxy signer to sign messages. The proposed scheme is based on the regular ElGamal signature. In addition, the fair privacy of the proxy signer is maintained. That means, the privacy of the proxy signer is preserved; and the privacy can be revealed when it is necessary.

Keywords: ElGamal signature, Proxy signature, Security, Hash function, Fair privacy.

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148 Signature Identification Scheme Based on Iterated Function Systems

Authors: Nadia M. G. AL-Saidi

Abstract:

Since 1984 many schemes have been proposed for digital signature protocol, among them those that based on discrete log and factorizations. However a new identification scheme based on iterated function (IFS) systems are proposed and proved to be more efficient. In this study the proposed identification scheme is transformed into a digital signature scheme by using a one way hash function. It is a generalization of the GQ signature schemes. The attractor of the IFS is used to obtain public key from a private one, and in the encryption and decryption of a hash function. Our aim is to provide techniques and tools which may be useful towards developing cryptographic protocols. Comparisons between the proposed scheme and fractal digital signature scheme based on RSA setting, as well as, with the conventional Guillou-Quisquater signature, and RSA signature schemes is performed to prove that, the proposed scheme is efficient and with high performance.

Keywords: Digital signature, Fractal, Iterated function systems(IFS), Guillou-Quisquater (GQ) protocol, Zero-knowledge (ZK)

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147 Performance Analysis of Certificateless Signature for IKE Authentication

Authors: Nazrul M. Ahmad, Asrul H. Yaacob, Ridza Fauzi, Alireza Khorram

Abstract:

Elliptic curve-based certificateless signature is slowly gaining attention due to its ability to retain the efficiency of identity-based signature to eliminate the need of certificate management while it does not suffer from inherent private key escrow problem. Generally, cryptosystem based on elliptic curve offers equivalent security strength at smaller key sizes compared to conventional cryptosystem such as RSA which results in faster computations and efficient use of computing power, bandwidth, and storage. This paper proposes to implement certificateless signature based on bilinear pairing to structure the framework of IKE authentication. In this paper, we perform a comparative analysis of certificateless signature scheme with a well-known RSA scheme and also present the experimental results in the context of signing and verification execution times. By generalizing our observations, we discuss the different trade-offs involved in implementing IKE authentication by using certificateless signature.

Keywords: Certificateless signature, IPSec, RSA signature, IKE authentication.

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146 Offline Handwritten Signature Recognition

Authors: Gulzar A. Khuwaja, Mohammad S. Laghari

Abstract:

Biometrics, which refers to identifying an individual based on his or her physiological or behavioral characteristics, has the capability to reliably distinguish between an authorized person and an imposter. Signature verification systems can be categorized as offline (static) and online (dynamic). This paper presents a neural network based recognition of offline handwritten signatures system that is trained with low-resolution scanned signature images.

Keywords: Pattern Recognition, Computer Vision, AdaptiveClassification, Handwritten Signature Recognition.

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145 Implementation of RSA Blind Signature on CryptO-0N2 Protocol

Authors: Esti Rahmawati Agustina, Is Esti Firmanesa

Abstract:

Blind Signature were introduced by Chaum. In this scheme, a signer can “sign” a document without knowing the document contain. This is particularly important in electronic voting. CryptO-0N2 is an electronic voting protocol which is development of CryptO-0N. During its development this protocol has not been furnished with the requirement of blind signature, so the choice of voters can be determined by counting center. In this paper will be presented of implementation of blind signature using RSA algorithm.

Keywords: Blind signature, electronic voting protocol, RSA algorithm.

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144 A Collusion-Resistant Distributed Signature Delegation Based on Anonymous Mobile Agent

Authors: Omaima Bamasak

Abstract:

This paper presents a novel method that allows an agent host to delegate its signing power to an anonymous mobile agent in such away that the mobile agent does not reveal any information about its host-s identity and, at the same time, can be authenticated by the service host, hence, ensuring fairness of service provision. The solution introduces a verification server to verify the signature generated by the mobile agent in such a way that even if colluding with the service host, both parties will not get more information than what they already have. The solution incorporates three methods: Agent Signature Key Generation method, Agent Signature Generation method, Agent Signature Verification method. The most notable feature of the solution is that, in addition to allowing secure and anonymous signature delegation, it enables tracking of malicious mobile agents when a service host is attacked. The security properties of the proposed solution are analyzed, and the solution is compared with the most related work.

Keywords: Anonymous signature delegation, collusion resistance, e-commerce fairness, mobile agent security.

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143 A Proxy Multi-Signature Scheme with Anonymous Vetoable Delegation

Authors: Pei-yih Ting, Dream-Ming Huang, Xiao-Wei Huang

Abstract:

Frequently a group of people jointly decide and authorize a specific person as a representative in some business/poitical occasions, e.g., the board of a company authorizes the chief executive officer to close a multi-billion acquisition deal. In this paper, an integrated proxy multi-signature scheme that allows anonymously vetoable delegation is proposed. This protocol integrates mechanisms of private veto, distributed proxy key generation, secure transmission of proxy key, and existentially unforgeable proxy multi-signature scheme. First, a provably secure Guillou-Quisquater proxy signature scheme is presented, then the “zero-sharing" protocol is extended over a composite modulus multiplicative group, and finally the above two are combined to realize the GQ proxy multi-signature with anonymously vetoable delegation. As a proxy signature scheme, this protocol protects both the original signers and the proxy signer. The modular design allows simplified implementation with less communication overheads and better computation performance than a general secure multi-party protocol.

Keywords: GQ proxy signature, proxy multi-signature, zero-sharing protocol, secure multi-party protocol, private veto protocol

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142 Simulation of Lightning Surge Propagation in Transmission Lines Using the FDTD Method

Authors: Kokiat Aodsup, Thanatchai Kulworawanichpong

Abstract:

This paper describes a finite-difference time-domainFDTD) method to analyze lightning surge propagation in electric transmission lines. Numerical computation of solving the Telegraphist-s equations is determined and investigated its effectiveness. A source of lightning surge wave on power transmission lines is modeled by using Heidler-s surge model. The proposed method was tested against medium-voltage power transmission lines in comparison with the solution obtained by using lattice diagram. As a result, the calculation showed that the method is one of accurate methods to analyze transient lightning wave in power transmission lines.

Keywords: Traveling wave, Lightning surge, Bewley lattice diagram, Telegraphist's equations, Finite-difference time-domain (FDTD) method,

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141 New Proxy Signatures Preserving Privacy and as Secure as ElGamal Signatures

Authors: Song Han, Elizabeth Chang, Jie Wang, Wanquan Liu

Abstract:

Digital signature is a useful primitive to attain the integrity and authenticity in various wire or wireless communications. Proxy signature is one type of the digital signatures. It helps the proxy signer to sign messages on behalf of the original signer. It is very useful when the original signer (e.g. the president of a company) is not available to sign a specific document. If the original signer can not forge valid proxy signatures through impersonating the proxy signer, it will be robust in a virtual environment; thus the original signer can not shift any illegal action initiated by herself to the proxy signer. In this paper, we propose a new proxy signature scheme. The new scheme can prevent the original signer from impersonating the proxy signer to sign messages. The proposed scheme is based on the regular ElGamal signature. In addition, the fair privacy of the proxy signer is maintained. That means, the privacy of the proxy signer is preserved; and the privacy can be revealed when it is necessary.

Keywords: ElGamal signature, proxy signature, security, hash function, fair privacy.

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140 Simulation of Surge Protection for a Direct Current Circuit

Authors: Pedro Luis Ferrer Penalver, Edmundo da Silva Braga

Abstract:

In this paper, the performance of a simple surge protection for a direct current circuit was simulated. The protection circuit was developed from modified electric macro models of a gas discharge tube and a transient voltage suppressor diode. Moreover, a combination wave generator circuit was used as source of energy surges. The simulations showed that the circuit presented ensures immunity corresponding with test level IV of the IEC 61000-4-5:2014 international standard. The developed circuit can be modified to meet the requirements of any other equipment to be protected. Similarly, the parameters of the combination wave generator can be changed to provide different surge amplitudes.

Keywords: Combination wave generator, IEC 61000-4-5, Pspice simulation, surge protection.

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139 A Secure Blind Signature Scheme for Computation Limited Users

Authors: Chun-I Fan, Ming-Te Chen

Abstract:

This manuscript presents a fast blind signature scheme with extremely low computation for users. Only several modular additions and multiplications are required for a user to obtain and verify a signature in the proposed scheme. Comparing with the existing ones in the literature, the scheme greatly reduces the computations for users.

Keywords: Blind signatures, Untraceable electronic cash, Security & privacy, Electronic commerce

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138 Triangular Geometric Feature for Offline Signature Verification

Authors: Zuraidasahana Zulkarnain, Mohd Shafry Mohd Rahim, Nor Anita Fairos Ismail, Mohd Azhar M. Arsad

Abstract:

Handwritten signature is accepted widely as a biometric characteristic for personal authentication. The use of appropriate features plays an important role in determining accuracy of signature verification; therefore, this paper presents a feature based on the geometrical concept. To achieve the aim, triangle attributes are exploited to design a new feature since the triangle possesses orientation, angle and transformation that would improve accuracy. The proposed feature uses triangulation geometric set comprising of sides, angles and perimeter of a triangle which is derived from the center of gravity of a signature image. For classification purpose, Euclidean classifier along with Voting-based classifier is used to verify the tendency of forgery signature. This classification process is experimented using triangular geometric feature and selected global features. Based on an experiment that was validated using Grupo de Senales 960 (GPDS-960) signature database, the proposed triangular geometric feature achieves a lower Average Error Rates (AER) value with a percentage of 34% as compared to 43% of the selected global feature. As a conclusion, the proposed triangular geometric feature proves to be a more reliable feature for accurate signature verification.

Keywords: biometrics, euclidean classifier, feature extraction, offline signature verification, VOTING-based classifier

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137 Secure Proxy Signature Based on Factoring and Discrete Logarithm

Authors: H. El-Kamchouchi, Heba Gaber, Fatma Ahmed, Dalia H. El-Kamchouchi

Abstract:

A digital signature is an electronic signature form used by an original signer to sign a specific document. When the original signer is not in his office or when he/she travels outside, he/she delegates his signing capability to a proxy signer and then the proxy signer generates a signing message on behalf of the original signer. The two parties must be able to authenticate one another and agree on a secret encryption key, in order to communicate securely over an unreliable public network. Authenticated key agreement protocols have an important role in building a secure communications network between the two parties. In this paper, we present a secure proxy signature scheme over an efficient and secure authenticated key agreement protocol based on factoring and discrete logarithm problem.

Keywords: Discrete logarithm, factoring, proxy signature, key agreement.

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136 Numerical Analysis of Wave and Hydrodynamic Models for Energy Balance and Primitive Equations

Authors: Worachat Wannawong, Usa W. Humphries, Prungchan Wongwises, Suphat Vongvisessomjai, Wiriya Lueangaram

Abstract:

A numerical analysis of wave and hydrodynamic models is used to investigate the influence of WAve and Storm Surge (WASS) in the regional and coastal zones. The numerical analyzed system consists of the WAve Model Cycle 4 (WAMC4) and the Princeton Ocean Model (POM) which used to solve the energy balance and primitive equations respectively. The results of both models presented the incorporated surface wave in the regional zone affected the coastal storm surge zone. Specifically, the results indicated that the WASS generally under the approximation is not only the peak surge but also the coastal water level drop which can also cause substantial impact on the coastal environment. The wave–induced surface stress affected the storm surge can significantly improve storm surge prediction. Finally, the calibration of wave module according to the minimum error of the significant wave height (Hs) is not necessarily result in the optimum wave module in the WASS analyzed system for the WASS prediction.

Keywords: energy balance equation, numerical analysis, primitiveequation, storm surge, wave.

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135 Online Signature Verification Using Angular Transformation for e-Commerce Services

Authors: Peerapong Uthansakul, Monthippa Uthansakul

Abstract:

The rapid growth of e-Commerce services is significantly observed in the past decade. However, the method to verify the authenticated users still widely depends on numeric approaches. A new search on other verification methods suitable for online e-Commerce is an interesting issue. In this paper, a new online signature-verification method using angular transformation is presented. Delay shifts existing in online signatures are estimated by the estimation method relying on angle representation. In the proposed signature-verification algorithm, all components of input signature are extracted by considering the discontinuous break points on the stream of angular values. Then the estimated delay shift is captured by comparing with the selected reference signature and the error matching can be computed as a main feature used for verifying process. The threshold offsets are calculated by two types of error characteristics of the signature verification problem, False Rejection Rate (FRR) and False Acceptance Rate (FAR). The level of these two error rates depends on the decision threshold chosen whose value is such as to realize the Equal Error Rate (EER; FAR = FRR). The experimental results show that through the simple programming, employed on Internet for demonstrating e-Commerce services, the proposed method can provide 95.39% correct verifications and 7% better than DP matching based signature-verification method. In addition, the signature verification with extracting components provides more reliable results than using a whole decision making.

Keywords: Online signature verification, e-Commerce services, Angular transformation.

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134 CFD Simulation of Surge Wave Generated by Flow-Like Landslides

Authors: Liu-Chao Qiu

Abstract:

The damage caused by surge waves generated in water bodies by flow-like landslides can be very high in terms of human lives and economic losses. The complicated phenomena occurred in this highly unsteady process are difficult to model because three interacting phases: air, water and sediment are involved. The problem therefore is challenging since the effects of non-Newtonian fluid describing the rheology of the flow-like landslides, multi-phase flow and free surface have to be included in the simulation. In this work, the commercial computational fluid dynamics (CFD) package FLUENT is used to model the surge waves due to flow-like landslides. The comparison between the numerical results and experimental data reported in the literature confirms the accuracy of the method.

Keywords: Flow-like landslide, surge wave, VOF, non-Newtonian fluids, multi-phase flows, free surface flow.

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133 Separating Permanent and Induced Magnetic Signature: A Simple Approach

Authors: O. J. G. Somsen, G. P. M. Wagemakers

Abstract:

Magnetic signature detection provides sensitive detection of metal objects, especially in the natural environment. Our group is developing a tabletop setup for magnetic signatures of various small and model objects. A particular issue is the separation of permanent and induced magnetization. While the latter depends only on the composition and shape of the object, the former also depends on the magnetization history. With common deperming techniques, a significant permanent signature may still remain, which confuses measurements of the induced component. We investigate a basic technique of separating the two. Measurements were done by moving the object along an aluminum rail while the three field components are recorded by a detector attached near the center. This is done first with the rail parallel to the Earth magnetic field and then with anti-parallel orientation. The reversal changes the sign of the induced- but not the permanent magnetization so that the two can be separated. Our preliminary results on a small iron block show excellent reproducibility. A considerable permanent magnetization was indeed present, resulting in a complex asymmetric signature. After separation, a much more symmetric induced signature was obtained that can be studied in detail and compared with theoretical calculations.

Keywords: Magnetic signature, data analysis, magnetization, deperming techniques.

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132 A Multi-Signature Scheme based on Coding Theory

Authors: Mohammed Meziani, Pierre-Louis Cayrel

Abstract:

In this paper we propose two first non-generic constructions of multisignature scheme based on coding theory. The first system make use of the CFS signature scheme and is secure in random oracle while the second scheme is based on the KKS construction and is a few times. The security of our construction relies on a difficult problems in coding theory: The Syndrome Decoding problem which has been proved NP-complete [4].

Keywords: Post-quantum cryptography, Coding-based cryptography, Digital signature, Multisignature scheme.

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131 Dual Construction of Stern-based Signature Scheme

Authors: Pierre-Louis Cayrel, Sidi Mohamed El Yousfi Alaoui

Abstract:

In this paper, we propose a dual version of the first threshold ring signature scheme based on error-correcting code proposed by Aguilar et. al in [1]. Our scheme uses an improvement of Véron zero-knowledge identification scheme, which provide smaller public and private key sizes and better computation complexity than the Stern one. This scheme is secure in the random oracle model.

Keywords: Stern algorithm, Véron algorithm, threshold ring signature, post-quantum cryptography.

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130 A Pairing-based Blind Signature Scheme with Message Recovery

Authors: Song Han, Elizabeth Chang

Abstract:

Blind signatures enable users to obtain valid signatures for a message without revealing its content to the signer. This paper presents a new blind signature scheme, i.e. identity-based blind signature scheme with message recovery. Due to the message recovery property, the new scheme requires less bandwidth than the identitybased blind signatures with similar constructions. The scheme is based on modified Weil/Tate pairings over elliptic curves, and thus requires smaller key sizes for the same level of security compared to previous approaches not utilizing bilinear pairings. Security and efficiency analysis for the scheme is provided in this paper.

Keywords: Blind Signature, Message Recovery, Pairings, Elliptic Curves, Blindness

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129 Account Management Method with Blind Signature Scheme

Authors: Ryu Watanabe, Yutaka Miyake

Abstract:

Reducing the risk of information leaks is one of the most important functions of identity management systems. To achieve this purpose, Dey et al. have already proposed an account management method for a federated login system using a blind signature scheme. In order to ensure account anonymity for the authentication provider, referred to as an IDP (identity provider), a blind signature scheme is utilized to generate an authentication token on an authentication service and the token is sent to an IDP. However, there is a problem with the proposed system. Malicious users can establish multiple accounts on an IDP by requesting such accounts. As a measure to solve this problem, in this paper, the authors propose an account checking method that is performed before account generation.

Keywords: identity management, blind signature, privacy protection

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128 Gene Expression Signature for Classification of Metastasis Positive and Negative Oral Cancer in Homosapiens

Authors: A. Shukla, A. Tarsauliya, R. Tiwari, S. Sharma

Abstract:

Cancer classification to their corresponding cohorts has been key area of research in bioinformatics aiming better prognosis of the disease. High dimensionality of gene data has been makes it a complex task and requires significance data identification technique in order to reducing the dimensionality and identification of significant information. In this paper, we have proposed a novel approach for classification of oral cancer into metastasis positive and negative patients. We have used significance analysis of microarrays (SAM) for identifying significant genes which constitutes gene signature. 3 different gene signatures were identified using SAM from 3 different combination of training datasets and their classification accuracy was calculated on corresponding testing datasets using k-Nearest Neighbour (kNN), Fuzzy C-Means Clustering (FCM), Support Vector Machine (SVM) and Backpropagation Neural Network (BPNN). A final gene signature of only 9 genes was obtained from above 3 individual gene signatures. 9 gene signature-s classification capability was compared using same classifiers on same testing datasets. Results obtained from experimentation shows that 9 gene signature classified all samples in testing dataset accurately while individual genes could not classify all accurately.

Keywords: Cancer, Gene Signature, SAM, Classification.

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