Search results for: T. Benslimane

2 Implementation and Comparison between Two Algorithms of Three-Level Neutral Point Clamped Voltage Source Inverter

Authors: K. Benamrane, T. Abdelkrim, T. Benslimane, Aeh. Benkhelifa, B. Bezza

Abstract:

This paper presents a comparison between two Pulse Width Modulation (PWM) algorithms applied to a three-level Neutral Point Clamped (NPC) Voltage Source Inverter (VSI). The first algorithm applied is the triangular-sinusoidal strategy; the second is the Space Vector Pulse Width Modulation (SVPWM) strategy. In the first part, we present a topology of three-level NCP VSI. After that, we develop the two PWM strategies to control this converter. At the end the experimental results are presented.

Keywords: Multilevel inverter, Space vector pulse width modulation (SVPWM), triangular-sinusoidal strategy.

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1 High Glucose Increases Acetylcholine-Induced Ca2+ Entry and Protein Expression of STIM1

Authors: Hong Ding, Fatiha Benslimane, Isra Marei, Chris R. Triggle

Abstract:

Hyperglycaemia is a key factor that contributes to the development of diabetes-related microvascular disease and a major risk factor for endothelial dysfunction. In the current study, we have explored glucose-induced abnormal intracellular calcium (Ca2+ i) homeostasis in mouse microvessel endothelial cells (MMECs) in high glucose (HG) (40mmol/L) versus control (low glucose, LG) (11 mmol/L). We demonstrated that the exposure of MMECs to HG for 3 days did not change basal Ca2+ i, however, there was a significant increase of acetylcholine-induced Ca2+ entry. Western blots illustrated that exposure to HG also increased STIM1 (Stromal Interaction Molecule 1), but not Orai1 (the pore forming subunit), protein expression levels. Although the link between HG-induced changes in STIM1 expression, enhanced Ca2+ entry and endothelial dysfunction requires further study, the current data are suggestive that targeting these pathways may reduce the impact of HG on endothelial function.

Keywords: store-operated calcium entry, hyperglycaemia, STIM1, endothelial dysfunction

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