Search results for: blood flow
516 Formal Verification of Cache System Using a Novel Cache Memory Model
Authors: Guowei Hou, Lixin Yu, Wei Zhuang, Hui Qin, Xue Yang
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Formal verification is proposed to ensure the correctness of the design and make functional verification more efficient. As cache plays a vital role in the design of System on Chip (SoC), and cache with Memory Management Unit (MMU) and cache memory unit makes the state space too large for simulation to verify, then a formal verification is presented for such system design. In the paper, a formal model checking verification flow is suggested and a new cache memory model which is called “exhaustive search model” is proposed. Instead of using large size ram to denote the whole cache memory, exhaustive search model employs just two cache blocks. For cache system contains data cache (Dcache) and instruction cache (Icache), Dcache memory model and Icache memory model are established separately using the same mechanism. At last, the novel model is employed to the verification of a cache which is module of a custom-built SoC system that has been applied in practical, and the result shows that the cache system is verified correctly using the exhaustive search model, and it makes the verification much more manageable and flexible.
Keywords: Cache system, formal verification, novel model, System on Chip (SoC).
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2298515 Effect of Model Dimension in Numerical Simulation on Assessment of Water Inflow to Tunnel in Discontinues Rock
Authors: Hadi Farhadian, Homayoon Katibeh
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Groundwater inflow to the tunnels is one of the most important problems in tunneling operation. The objective of this study is the investigation of model dimension effects on tunnel inflow assessment in discontinuous rock masses using numerical modeling. In the numerical simulation, the model dimension has an important role in prediction of water inflow rate. When the model dimension is very small, due to low distance to the tunnel border, the model boundary conditions affect the estimated amount of groundwater flow into the tunnel and results show a very high inflow to tunnel. Hence, in this study, the two-dimensional universal distinct element code (UDEC) used and the impact of different model parameters, such as tunnel radius, joint spacing, horizontal and vertical model domain extent has been evaluated. Results show that the model domain extent is a function of the most significant parameters, which are tunnel radius and joint spacing.
Keywords: Water inflow, Tunnel, Discontinues rock, Numerical simulation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2509514 Entropy Generation Analysis of Free Convection Film Condensation on a Vertical Ellipsoid with Variable Wall Temperature
Authors: Sheng-An Yang, Ren-Yi Hung, Ying-Yi Ho
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This paper aims to perform the second law analysis of thermodynamics on the laminar film condensation of pure saturated vapor flowing in the direction of gravity on an ellipsoid with variable wall temperature. The analysis provides us understanding how the geometric parameter- ellipticity and non-isothermal wall temperature variation amplitude “A." affect entropy generation during film-wise condensation heat transfer process. To understand of which irreversibility involved in this condensation process, we derived an expression for the entropy generation number in terms of ellipticity and A. The result indicates that entropy generation increases with ellipticity. Furthermore, the irreversibility due to finite temperature difference heat transfer dominates over that due to condensate film flow friction and the local entropy generation rate decreases with increasing A in the upper half of ellipsoid. Meanwhile, the local entropy generation rate enhances with A around the rear lower half of ellipsoid.Keywords: Free convection; Non-isothermal; Thermodynamic second law; Entropy, Ellipsoid.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1956513 The Self-Propelled Model of a Boat, Based on the Wave Thrust
Authors: V. Arabadzhi
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We attempted investigate a boat model, based on the conversion of energy of surface wave into a sequence of unidirectional pulses of jet spurts, in other words - model of the boat, which is thrusting by the waves field on water surface. These pulses are forming some average reactive stream from the output nozzle on the stern of boat. The suggested model provides the conversion of its oscillatory motions (both pitching and rolling) into a jet flow. This becomes possible due to special construction of the boat and due to several details, sensitive to the local wave field. The boat model presents the uniflow jet engine without slow conversions of mechanical energy into intermediate forms and without any external sources of energy (besides surface waves). Motion of boat is characterized by fast jerks and average onward velocity, which exceeds the velocities of liquid particles in the wave.Keywords: Flat-bottomed boat, Underwater wing, Input and output nozzles, Wave thrust, Conversion of wave into a jet stream, Oscillatory motion and onward motion, Squid-like pump, Hatch-like pump, The thrust due to lifting float, The thrust due to radiation reaction.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1840512 Supply Chain Management and E-Commerce Technology Adoption among Logistics Service Providers in Malaysia
Authors: Mohd Iskandar bin Illyas Tan, Iziati Saadah bt Ibrahim
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Logistics is part of the supply chain processes that plans, implements, and controls the efficient and effective forward and reverse flow and storage of goods, services, and related information between the point of origin and the point of consumption in order to meet customer requirements. This research aims to investigate the current status and future direction of the use of Information Technology (IT) for logistics, focusing on Supply Chain Management (SCM) and E-Commerce adoption in Malaysia. Therefore, this research stresses on the type of technology being adopted, factors, benefits and barriers affecting the innovation in SCM and E-Commerce technology adoption among Logistics Service Providers (LSP). A mailed questionnaire survey was conducted to collect data from 265 logistics companies in Johor. The research revealed a high level of SCM technology adoption among LSP as they had adopted SCM technology in various business processes while they perceived a high level of benefits from SCM adoption.Keywords: E-Commerce, Logistics Service Providers, Malaysia, Supply Chain Management.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 4921511 Profile Analysis and Experiences on the Tourism of Jalapão State Park, Tocantins, Brazil
Authors: Veruska C. Dutra, Mary L. G. S. Senna, Felipe S. Spindler
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The State Park Jalapão - PEJ proved to be one of the protected areas that has attracted tourists from all over the world with its unique scenic landscapes. Although the region already has a considerable tourist flow, to our knowledge there is a lack of continuity of studies in the region capable of drawing a plan of activities, such as the profile of the tourist and analysis of their experiences in the region, carried out from 2006-2007. Therefore, this study was proposed to know the profile and experiences of tourists visiting the park today, making a connection with the earlier study, in order to generate subsidies to trace improvement actions. We conducted interviews with tourists in the main tourism season 2015. The results show that after eight years of carrying out the first study, there were no changes, highlighting the lack of a tourism plan for the park.
Keywords: Jalapão, profile tourist, level of satisfaction.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1045510 Early Melt Season Variability of Fast Ice Degradation Due to Small Arctic Riverine Heat Fluxes
Authors: Grace E. Santella, Shawn G. Gallaher, Joseph P. Smith
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In order to determine the importance of small-system riverine heat flux on regional landfast sea ice breakup, our study explores the annual spring freshet of the Sagavanirktok River from 2014-2019. Seasonal heat cycling ultimately serves as the driving mechanism behind the freshet; however, as an emerging area of study, the extent to which inland thermodynamics influence coastal tundra geomorphology and connected landfast sea ice has not been extensively investigated in relation to small-scale Arctic river systems. The Sagavanirktok River is a small-to-midsized river system that flows south-to-north on the Alaskan North Slope from the Brooks mountain range to the Beaufort Sea at Prudhoe Bay. Seasonal warming in the spring rapidly melts snow and ice in a northwards progression from the Brooks Range and transitional tundra highlands towards the coast and when coupled with seasonal precipitation, results in a pulsed freshet that propagates through the Sagavanirktok River. The concentrated presence of newly exposed vegetation in the transitional tundra region due to spring melting results in higher absorption of solar radiation due to a lower albedo relative to snow-covered tundra and/or landfast sea ice. This results in spring flood runoff that advances over impermeable early-season permafrost soils with elevated temperatures relative to landfast sea ice and sub-ice flow. We examine the extent to which interannual temporal variability influences the onset and magnitude of river discharge by analyzing field measurements from the United States Geological Survey (USGS) river and meteorological observation sites. Rapid influx of heat to the Arctic Ocean via riverine systems results in a noticeable decay of landfast sea ice independent of ice breakup seaward of the shear zone. Utilizing MODIS imagery from NASA’s Terra satellite, interannual variability of river discharge is visualized, allowing for optical validation that the discharge flow is interacting with landfast sea ice. Thermal erosion experienced by sediment fast ice at the arrival of warm overflow preconditions the ice regime for rapid thawing. We investigate the extent to which interannual heat flux from the Sagavanirktok River’s freshet significantly influences the onset of local landfast sea ice breakup. The early-season warming of atmospheric temperatures is evidenced by the presence of storms which introduce liquid, rather than frozen, precipitation into the system. The resultant decreased albedo of the transitional tundra supports the positive relationship between early-season precipitation events, inland thermodynamic cycling, and degradation of landfast sea ice. Early removal of landfast sea ice increases coastal erosion in these regions and has implications for coastline geomorphology which stress industrial, ecological, and humanitarian infrastructure.
Keywords: Albedo, freshet, landfast sea ice, riverine heat flux, seasonal heat cycling.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 457509 The Effect of Eight Weeks of Aerobic Training on Indices of Cardio-Respiratory and Exercise Tolerance in Overweight Women with Chronic Asthma
Authors: Somayeh Negahdari, Mohsen Ghanbarzadeh, Masoud Nikbakht, Heshmatolah Tavakol
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Asthma, obesity and overweight are the main factors causing change within the heart and respiratory airways. Asthma symptoms are normally observed during exercising. Epidemiological studies have indicated asthma symptoms occurring due to certain lifestyle habits; for example, a sedentary lifestyle. In this study, eight weeks of aerobic exercises resulted in a positive effect overall in overweight women experiencing mild chronic asthma. The quasi-experimental applied research has been done based on experimental and control groups. The experimental group (seven patients) and control group (n = 7) were graded before and after the test. According to the Borg dyspnea and fatigue Perception Index, the training intensity has determined. Participants in the study performed a sub-maximal aerobic activity schedule (45% to 80% of maximum heart rate) for two months, while the control group (n = 7) stayed away from aerobic exercise. Data evaluation and analysis of covariance compared both the pre-test and post-test with paired t-test at significance level of P≤ 0.05. After eight weeks of exercise, the results of the experimental group show a significant decrease in resting heart rate, systolic blood pressure, minute ventilation, while a significant increase in maximal oxygen uptake and tolerance activity (P ≤ 0.05). In the control group, there was no significant difference in these parameters ((P ≤ 0.05). The results indicate the aerobic activity can strengthen the respiratory muscles, while other physiological factors could result in breathing and heart recovery. Aerobic activity also resulted in favorable changes in cardiovascular parameters, and exercise tolerance of overweight women with chronic asthma.
Keywords: Asthma, respiratory cardiac index, exercise tolerance, aerobic, overweight.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 768508 Unsteady Natural Convection Heat and Mass Transfer of Non-Newtonian Casson Fluid along a Vertical Wavy Surface
Authors: A. Mahdy, Sameh E. Ahmed
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Detailed numerical calculations are illustrated in our investigation for unsteady natural convection heat and mass transfer of non-Newtonian Casson fluid along a vertical wavy surface. The surface of the plate is kept at a constant temperature and uniform concentration. To transform the complex wavy surface to a flat plate, a simple coordinate transformation is employed. The resulting partial differential equations are solved using the fully implicit finite difference method with SUR procedure. Flow and heat transfer characteristics are investigated for a wide range of values of the Casson parameter, the dimensionless time parameter, the buoyancy ratio and the amplitude-wavelength parameter. It is found that, the variations of the Casson parameter have significant effects on the fluid motion, heat and mass transfer. Also, the maximum and minimum values of the local Nusselt and Sherwood numbers increase by increase either the Casson parameter or the buoyancy ratio.Keywords: Casson fluid, wavy surface, mass transfer, transient analysis.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 918507 Influence of Urban Fabric on Child’s Upbringing: A Comparative Analysis between Modern and Traditional City
Authors: Mohamed A. Tantawy, Nourelhoda A. Hussein, Moataz A. Mahrous
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New planning and city design theories are continuously debated and optimized for seeking efficiency and adequacy in economic and life quality aspects. Here, we examine the children-city relationship, to reflect on how modern and traditional cities affect the social climate. We adopt children as a proper caliber for urbanism, as for their very young age, they are independent and attached to family. Their fragility offers a chance to gauge how various urban settings directly affect their feeling of safety, containment, and their perception of belonging for home territory. The importance of street play for the child development process is discussed thoroughly. The authority they have on their play (when and what to play) pushes us to our conclusion. A mediocre built environment characterized by spontaneity and human-scale semi-private urban spaces, is irreplaceable by a perfectly designed far away playgrounds. Street play has a huge role in empowering children for a gradual engagement with grown-ups’ urban flow.
Keywords: Child's psychology, social activity, street play, urban fabric.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1567506 Convective Heat Transfer Enhancement in an Enclosure with Fin Utilizing Nano Fluids
Authors: S. H. Anilkumar, Ghulam Jilani
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The objective of the present work is to conduct investigations leading to a more complete explanation of single phase natural convective heat transfer in an enclosure with fin utilizing nano fluids. The nano fluid used, which is composed of Aluminum oxide nano particles in suspension of Ethylene glycol, is provided at various volume fractions. The study is carried out numerically for a range of Rayleigh numbers, fin heights and aspect ratio. The flow and temperature distributions are taken to be two-dimensional. Regions with the same velocity and temperature distributions are identified as symmetry of sections. One half of such a rectangular region is chosen as the computational domain taking into account the symmetry about the fin. Transport equations are modeled by a stream functionvorticity formulation and are solved numerically by finite-difference schemes. Comparisons with previously published works on the basis of special cases are done. Results are presented in the form of streamline, vector and isotherm plots as well as the variation of local Nusselt number along the fin under different conditions.Keywords: Fin height, Nano fluid, natural convection, Rayleigh number.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1469505 Climate Change Finger Prints in Mountainous Upper Euphrates Basin
Authors: Abdullah Gokhan Yilmaz, Monzur Alam Imteaz, Shirley Gato-Trinidad, Iqbal Hossain
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Climate change leading to global warming affects the earth through many different ways such as weather (temperature, precipitation, humidity and the other parameters of weather), snow coverage and ice melting, sea level rise, hydrological cycles, quality of water, agriculture, forests, ecosystems and health. One of the most affected areas by climate change is hydrology and water resources. Regions where majority of runoff consists of snow melt are more sensitive to climate change. The first step of climate change studies is to establish trends of significant climate variables including precipitation, temperature and flow data to detect any potential climate change impacts already happened. Two popular non-parametric trend analysis methods, Mann-Kendal and Spearman-s Rho were applied to Upper Euphrates Basin (Turkey) to detect trends of precipitation, temperatures (maximum, minimum and average) and streamflow.Keywords: Climate change, precipitation, snow hydrology, trend analysis and Upper Euphrates Basin
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 55595504 Estimation of Uncertainty of Thermal Conductivity Measurement with Single Laboratory Validation Approach
Authors: Saowaluck Ukrisdawithid
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The thermal conductivity of thermal insulation materials are measured by Heat Flow Meter (HFM) apparatus. The components of uncertainty are complex and difficult on routine measurement by modelling approach. In this study, uncertainty of thermal conductivity measurement was estimated by single laboratory validation approach. The within-laboratory reproducibility was 1.1%. The standard uncertainty of method and laboratory bias by using SRM1453 expanded polystyrene board was dominant at 1.4%. However, it was assessed that there was no significant bias. For sample measurement, the sources of uncertainty were repeatability, density of sample and thermal conductivity resolution of HFM. From this approach to sample measurements, the combined uncertainty was calculated. In summary, the thermal conductivity of sample, polystyrene foam, was reported as 0.03367 W/m·K ± 3.5% (k = 2) at mean temperature 23.5 °C. The single laboratory validation approach is simple key of routine testing laboratory for estimation uncertainty of thermal conductivity measurement by using HFM, according to ISO/IEC 17025-2017 requirements. These are meaningful for laboratory competent improvement, quality control on products, and conformity assessment.
Keywords: Single laboratory validation approach, within-laboratory reproducibility, method and laboratory bias, certified reference material.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 808503 Platform Urbanism: Planning towards Hyper-Personalisation
Authors: Provides Ng
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Platform economy is a peer-to-peer model of distributing resources facilitated by community-based digital platforms. In recent years, digital platforms are rapidly reconfiguring the public realm using hyper-personalisation techniques. This paper aims at investigating how urban planning can leapfrog into the digital age to help relieve the rising tension of the global issue of labour flow; it discusses the means to transfer techniques of hyper-personalisation into urban planning for plasticity using platform technologies. This research first denotes the limitations of the current system of urban residency, where the system maintains itself on the circulation of documents, which are data on paper. Then, this paper tabulates how some of the institutions around the world, both public and private, digitise data, and streamline communications between a network of systems and citizens using platform technologies. Subsequently, this paper proposes ways in which hyper-personalisation can be utilised to form a digital planning platform. Finally, this paper concludes by reviewing how the proposed strategy may help to open up new ways of thinking about how we affiliate ourselves with cities.
Keywords: Platform urbanism, hyper-personalisation, urban residency, digital data.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 669502 Aerodynamic Stall Control of a Generic Airfoil using Synthetic Jet Actuator
Authors: Basharat Ali Haider, Naveed Durrani, Nadeem Aizud, Salimuddin Zahir
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The aerodynamic stall control of a baseline 13-percent thick NASA GA(W)-2 airfoil using a synthetic jet actuator (SJA) is presented in this paper. Unsteady Reynolds-averaged Navier-Stokes equations are solved on a hybrid grid using a commercial software to simulate the effects of a synthetic jet actuator located at 13% of the chord from the leading edge at a Reynolds number Re = 2.1x106 and incidence angles from 16 to 22 degrees. The experimental data for the pressure distribution at Re = 3x106 and aerodynamic coefficients at Re = 2.1x106 (angle of attack varied from -16 to 22 degrees) without SJA is compared with the computational fluid dynamic (CFD) simulation as a baseline validation. A good agreement of the CFD simulations is obtained for aerodynamic coefficients and pressure distribution. A working SJA has been integrated with the baseline airfoil and initial focus is on the aerodynamic stall control at angles of attack from 16 to 22 degrees. The results show a noticeable improvement in the aerodynamic performance with increase in lift and decrease in drag at these post stall regimes.Keywords: Active flow control, Aerodynamic stall, Airfoilperformance, Synthetic jet actuator.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2311501 Application of Feed Forward Neural Networks in Modeling and Control of a Fed-Batch Crystallization Process
Authors: Petia Georgieva, Sebastião Feyo de Azevedo
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This paper is focused on issues of nonlinear dynamic process modeling and model-based predictive control of a fed-batch sugar crystallization process applying the concept of artificial neural networks as computational tools. The control objective is to force the operation into following optimal supersaturation trajectory. It is achieved by manipulating the feed flow rate of sugar liquor/syrup, considered as the control input. A feed forward neural network (FFNN) model of the process is first built as part of the controller structure to predict the process response over a specified (prediction) horizon. The predictions are supplied to an optimization procedure to determine the values of the control action over a specified (control) horizon that minimizes a predefined performance index. The control task is rather challenging due to the strong nonlinearity of the process dynamics and variations in the crystallization kinetics. However, the simulation results demonstrated smooth behavior of the control actions and satisfactory reference tracking.
Keywords: Feed forward neural network, process modelling, model predictive control, crystallization process.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1875500 A Procedure to Assess Streamflow Rating Curves and Streamflow Sequences
Authors: Elena Carcano, Mirzi Betasolo
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This study aims to provide sub-hourly streamflow predictions and associated rating curves for small catchments of intermittent and torrential flow regime characterized by flash floods occurring especially during April and November. The methodology entails two lumped conceptual hydrological models which work in series. The total model is based upon eleven parameters and shows good flexibility in handling different input sets. Runoff Coefficient has contributed to improving the model’s performances and has been treated as an additional parameter; while Sensitivity Analysis has highlighted how slight changes in the model’s input can lead to changes in model’s output. The adopted procedure is steady and useful to give very practical engineering information at the expense of a parsimonious request both in input data and in the number of adopted parameters. According to the obtained results, the authors encourage the test of this combined procedure on different hydrological scenarios in order to provide information for poorly monitored catchments and not updated sites.
Keywords: Streamflow rating curve, chronological data, streamflow sequences, conceptual models.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 420499 Effects of Superheating on Thermodynamic Performance of Organic Rankine Cycles
Authors: Kyoung Hoon Kim
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Recently ORC(Organic Rankine Cycle) has attracted much attention due to its potential in reducing consumption of fossil fuels and its favorable characteristics to exploit low-grade heat sources. In this work thermodynamic performance of ORC with superheating of vapor is comparatively assessed for various working fluids. Special attention is paid to the effects of system parameters such as the evaporating temperature and the turbine inlet temperature on the characteristics of the system such as maximum possible work extraction from the given source, volumetric flow rate per 1 kW of net work and quality of the working fluid at turbine exit as well as thermal and exergy efficiencies. Results show that for a given source the thermal efficiency increases with decrease of the superheating but exergy efficiency may have a maximum value with respect to the superheating of the working fluid. Results also show that in selection of working fluid it is required to consider various criteria of performance characteristics as well as thermal efficiency.Keywords: organic Rankine cycle (ORC), low-grade energysource, Patel-Teja equation, thermodynamic performance
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2896498 Numerical Optimization of Trapezoidal Microchannel Heat Sinks
Authors: Yue-Tzu Yang, Shu-Ching Liao
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This study presents the numerical simulation of three-dimensional incompressible steady and laminar fluid flow and conjugate heat transfer of a trapezoidal microchannel heat sink using water as a cooling fluid in a silicon substrate. Navier-Stokes equations with conjugate energy equation are discretized by finite-volume method. We perform numerical computations for a range of 50 ≦ Re ≦ 600, 0.05W ≦ P ≦ 0.8W, 20W/cm2 ≦q"≦ 40W/cm2. The present study demonstrates the numerical optimization of a trapezoidal microchannel heat sink design using the response surface methodology (RSM) and the genetic algorithm method (GA). The results show that the average Nusselt number increases with an increase in the Reynolds number or pumping power, and the thermal resistance decreases as the pumping power increases. The thermal resistance of a trapezoidal microchannel is minimized for a constant heat flux and constant pumping power.
Keywords: Microchannel heat sinks, Conjugate heat transfer, Optimization, Genetic algorithm method.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2159497 Identification of Promiscuous Epitopes for Cellular Immune Responses in the Major Antigenic Protein Rv3873 Encoded by Region of Difference 1 of Mycobacterium tuberculosis
Authors: Abu Salim Mustafa
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Rv3873 is a relatively large size protein (371 amino acids in length) and its gene is located in the immunodominant genomic region of difference (RD)1 that is present in the genome of Mycobacterium tuberculosis but deleted from the genomes of all the vaccine strains of Bacillus Calmette Guerin (BCG) and most other mycobacteria. However, when tested for cellular immune responses using peripheral blood mononuclear cells from tuberculosis patients and BCG-vaccinated healthy subjects, this protein was found to be a major stimulator of cell mediated immune responses in both groups of subjects. In order to further identify the sequence of immunodominant epitopes and explore their Human Leukocyte Antigen (HLA)-restriction for epitope recognition, 24 peptides (25-mers overlapping with the neighboring peptides by 10 residues) covering the sequence of Rv3873 were synthesized chemically using fluorenylmethyloxycarbonyl chemistry and tested in cell mediated immune responses. The results of these experiments helped in the identification of an immunodominant peptide P9 that was recognized by people expressing varying HLA-DR types. Furthermore, it was also predicted to be a promiscuous binder with multiple epitopes for binding to HLA-DR, HLA-DP and HLA-DQ alleles of HLA-class II molecules that present antigens to T helper cells, and to HLA-class I molecules that present antigens to T cytotoxic cells. In addition, the evaluation of peptide P9 using an immunogenicity predictor server yielded a high score (0.94), which indicated a greater probability of this peptide to elicit a protective cellular immune response. In conclusion, P9, a peptide with multiple epitopes and ability to bind several HLA class I and class II molecules for presentation to cells of the cellular immune response, may be useful as a peptide-based vaccine against tuberculosis.
Keywords: Mycobacterium tuberculosis, Rv3873, peptides, vaccine
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 845496 Direct Power Control Strategies for Multilevel Inverter Based Custom Power Devices
Authors: S. Venkateshwarlu, B. P. Muni, A. D. Rajkumar, J. Praveen
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Custom power is a technology driven product and service solution which embraces a family devices such as Dynamic Voltage Restorer (DVR), Distributed Shunt Compensator (DSTATCOM), Solid State Breaker (SSB) etc which will provide power quality functions at distribution voltages. The rapid response of these devices enables them to operate in real time, providing continuous and dynamic control of the supply including voltage and reactive power regulation, harmonic reduction and elimination of voltage dips. This paper presents the benefits of multilevel inverters when they are used for DPC based custom power devices. Power flow control mechanism, salient features, advantages and disadvantages of direct power control (DPC) using lookup table, SVM, predictive voltage vector and hybrid DPC strategies are discussed in this paper. Simulation results of three level inverter based STATCOM, harmonic analysis of multi level inverters are presented at the end.Keywords: DPC, DPC-SVM, Dynamic voltage restorer, DSTATCOM, Multilevel inverter, PWM Converter, PDPC, VF-DPC.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2963495 Influence of Pier Modification Techniques for Reducing Scour around Bridge Piers
Authors: Rashid Farooq, Abdul Razzaq Ghumman, Hashim Nisar Hashmi
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Bridge piers often fail all over the world and the whole structure may be endangered due to scouring phenomena. Scouring has been linked to catastrophic failures that lead into the loss of human lives. Various techniques have been employed to extenuate the scouring process in order to assist the bridge designs. Pier modifications plays vital role to control scouring at the vicinity of the pier. This experimental study aims at monitoring the effectiveness of pier modification and temporal development of scour depth around a bridge pier by providing a collar, a cable or openings under the same flow conditions. Provision of a collar around the octagonal pier reduced more scour depth than that for other two configurations. Providing a collar around the octagonal pier found to be the best in reducing scour. The scour depth in front of pier was found to be 19.5% less than that at the octagonal pier without any modifications. Similarly, the scour depth around the octagonal pier having provision of a cable was less than that at pier with provision of openings. The scour depth around an octagonal pier was also compared with a plain circular pier and found to be 9.1% less.
Keywords: Scour, octagonal pier, collar, cable, openings.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1146494 A Survey on Supply Chain Management and E Commerce Technology Adoption among Logistics Service Providers in Johor
Authors: Mohd Iskandar bin Illyas Tan, Iziati Saadah bt Ibrahim
Abstract:
Logistics is part of the supply chain processes that plans, implements, and controls the efficient and effective forward and reverse flow and storage of goods, services, and related information between the point of origin and the point of consumption in order to meet customer requirements. This research aims to investigate the current status and future direction of the use of Information Technology (IT) for logistics, focusing on Supply Chain Management (SCM) and E-Commerce adoption in Johor. Therefore, this research stresses on the type of technology being adopted, factors, benefits and barriers affecting the innovation in SCM and ECommerce technology adoption among Logistics Service Providers (LSP). A mailed questionnaire survey was conducted to collect data from 265 logistics companies in Johor. The research revealed that SCM technology adoption among LSP was higher as they had adopted SCM technology in various business processes while they perceived a high level of benefits from SCM adoption. Obviously, ECommerce technology adoption among LSP is relatively low.
Keywords: E-Commerce, Johor, Logistics Service Providers, Supply Chain Management.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 3116493 Optimization of GAMM Francis Turbine Runner
Authors: Sh. Derakhshan, A. Mostafavi
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Nowadays, the challenge in hydraulic turbine design is the multi-objective design of turbine runner to reach higher efficiency. The hydraulic performance of a turbine is strictly depends on runner blades shape. The present paper focuses on the application of the multi-objective optimization algorithm to the design of a small Francis turbine runner. The optimization exercise focuses on the efficiency improvement at the best efficiency operating point (BEP) of the GAMM Francis turbine. A global optimization method based on artificial neural networks (ANN) and genetic algorithms (GA) coupled by 3D Navier-Stokes flow solver has been used to improve the performance of an initial geometry of a Francis runner. The results show the good ability of optimization algorithm and the final geometry has better efficiency with initial geometry. The goal was to optimize the geometry of the blades of GAMM turbine runner which leads to maximum total efficiency by changing the design parameters of camber line in at least 5 sections of a blade. The efficiency of the optimized geometry is improved from 90.7% to 92.5%. Finally, design parameters and the way of selection have been considered and discussed.Keywords: Francis Turbine, Runner, Optimization, CFD
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 3343492 Phenotypes of B Cells Differ in EBV-positive Burkitt-s lymphoma Derived Cell Lines
Authors: Irina Spaka, Rita Birkenfelde, Svetlana Kozireva, Jevgenija Osmjana, Madara Upmane, ElenaKashuba, Irina Kholodnyuk Holodnuka
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Epstein-Barr virus (EBV) is implicated in the pathogenesis of the endemic Burkitt-s lymphoma (BL). The EBVpositive BL-derived cell lines initially maintain the original tumor phenotype of EBV infection (latency I, LatI), but most of them drift toward a lymphoblast phenotype of EBV latency III (LatIII) during in vitro culturing. The aim of the present work was to characterize the B-cell subsets in EBV-positive BL cell lines and to verify whether a particular cell subset correlates with the type of EBV infection. The phenotype analysis of two EBV-negative and eleven EBV-positive (three of LatI and eight of LatIII) BL cell lines was performed by polychromatic flow cytomery, based on expression pattern of CD19, CD10, CD38, CD27, and CD5 markers. Two cell subsets, CD19+CD10+ and CD19+CD10-, were defined in LatIII BL cell lines. In both subsets, the CD27 and CD5 cell surface expression was detected in a proportion of the cells.
Keywords: B-cell subsets, Burkitt's lymphoma cell lines, EBV latency, phenotype profiles.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1958491 Implementation and Demonstration of Software-Defined Traffic Grooming
Authors: Lei Guo, Xu Zhang, Weigang Hou
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Since the traditional network is closed and it has no architecture to create applications, it has been unable to evolve with changing demands under the rapid innovation in services. Additionally, due to the lack of the whole network profile, the quality of service cannot be well guaranteed in the traditional network. The Software Defined Network (SDN) utilizes global resources to support on-demand applications/services via open, standardized and programmable interfaces. In this paper, we implement the traffic grooming application under a real SDN environment, and the corresponding analysis is made. In our SDN: 1) we use OpenFlow protocol to control the entire network by using software applications running on the network operating system; 2) several virtual switches are combined into the data forwarding plane through Open vSwitch; 3) An OpenFlow controller, NOX, is involved as a logically centralized control plane that dynamically configures the data forwarding plane; 4) The traffic grooming based on SDN is demonstrated through dynamically modifying the idle time of flow entries. The experimental results demonstrate that the SDN-based traffic grooming effectively reduces the end-to-end delay, and the improvement ratio arrives to 99%.
Keywords: NOX, OpenFlow, software defined network, traffic grooming.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1029490 An Efficient Passive Planar Micromixer with Finshaped Baffles in the Tee Channel for Wide Reynolds Number Flow Range
Authors: C. A. Cortes-Quiroz, A. Azarbadegan, E. Moeendarbary
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A new design of a planar passive T-micromixer with fin-shaped baffles in the mixing channel is presented. The mixing efficiency and the level of pressure loss in the channel have been investigated by numerical simulations in the range of Reynolds number (Re) 1 to 50. A Mixing index (Mi) has been defined to quantify the mixing efficiency, which results over 85% at both ends of the Re range, what demonstrates the micromixer can enhance mixing using the mechanisms of diffusion (lower Re) and convection (higher Re). Three geometric dimensions: radius of baffle, baffles pitch and height of the channel define the design parameters, and the mixing index and pressure loss are the performance parameters used to optimize the micromixer geometry with a multi-criteria optimization method. The Pareto front of designs with the optimum trade-offs, maximum mixing index with minimum pressure loss, is obtained. Experiments for qualitative and quantitative validation have been implemented.
Keywords: Computational fluids dynamics, fin-shaped baffle, mixing strategies, multi-objective optimization, passive micromixer.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1987489 Numerical Investigation on the Interior Wind Noise of a Passenger Car
Authors: Liu Ying-jie, Lu Wen-bo, Peng Cheng-jian
Abstract:
With the development of the automotive technology and electric vehicle, the contribution of the wind noise on the interior noise becomes the main source of noise. The main transfer path which the exterior excitation is transmitted through is the greenhouse panels and side windows. Simulating the wind noise transmitted into the vehicle accurately in the early development stage can be very challenging. The basic methodologies of this study were based on the Lighthill analogy; the exterior flow field around a passenger car was computed using unsteady Computational Fluid Dynamics (CFD) firstly and then a Finite Element Method (FEM) was used to compute the interior acoustic response. The major findings of this study include: 1) The Sound Pressure Level (SPL) response at driver’s ear locations is mainly induced by the turbulence pressure fluctuation; 2) Peaks were found over the full frequency range. It is found that the methodology used in this study could predict the interior wind noise induced by the exterior aerodynamic excitation in industry.
Keywords: Wind noise, computational fluid dynamics, finite element method, passenger car.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 861488 Experimental Study of Open Water Non-Series Marine Propeller Performance
Authors: M. A. Elghorab, A. Abou El-Azm Aly, A. S. Elwetedy, M. A. Kotb
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Later marine propeller is the main component of ship propulsion system. For a non-series propeller, it is difficult to indicate the open water marine propeller performance without an experimental study to measure the marine propeller parameters. In the present study, the open water performance of a non-series marine propeller has been carried out experimentally. The geometrical aspects of a commercial non-series marine propeller have been measured for a propeller blade area ratio of 0.3985. The measured propeller performance parameters were the thrust and torque coefficients for different propeller rotational speed and different water channel flow velocity, then the open water performance for the propeller has been plotted. In addition, a direct comparison between the obtained experimental results and a theoretical study of a B-series marine propeller of the same blade area ratio has been carried out. A correction factor has been introduced to apply the operating conditions of the experimental results to that of the theoretical study for the studied marine propeller.Keywords: Advance speed, marine propeller, open water performance, thrust coefficient, torque coefficient.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 3353487 Dynamics of a Vapour Bubble inside a Vertical Rigid Cylinder in the Absence of Buoyancy Forces
Authors: S. Mehran, S. Rouhi, F.Rouzbahani, E. Haghgoo
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In this paper, growth and collapse of a vapour bubble generated due to a local energy input inside a rigid cylinder and in the absence of buoyancy forces is investigated using Boundary Integral Equation Method and Finite Difference Method .The fluid is treated as potential flow and Boundary Integral Equation Method is used to solve Laplace-s equation for velocity potential. Different ratios of the diameter of the rigid cylinder to the maximum radius of the bubble are considered. Results show that during the collapse phase of the bubble inside a vertical rigid cylinder, two liquid micro jets are developed on the top and bottom sides of the vapour bubble and are directed inward. It is found that by increasing the ratio of the cylinder diameter to the maximum radius of the bubble, the rate of the growth and collapse phases of the bubble increases and the life time of the bubble decreases.Keywords: Vapour bubble, Vertical rigid cylinder, Boundaryelement method, Finite difference method, Buoyancy forces.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1576