Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 3

prognosis Related Publications

3 Intelligent Condition Monitoring Systems for Unmanned Aerial Vehicle Robots

Authors: A. P. Anvar, T. Dowling, T. Putland, A. M. Anvar, S.Grainger

Abstract:

This paper presents the application of Intelligent Techniques to the various duties of Intelligent Condition Monitoring Systems (ICMS) for Unmanned Aerial Vehicle (UAV) Robots. These Systems are intended to support these Intelligent Robots in the event of a Fault occurrence. Neural Networks are used for Diagnosis, whilst Fuzzy Logic is intended for Prognosis and Remedy. The ultimate goals of ICMS are to save large losses in financial cost, time and data.

Keywords: Neural Networks, Robots, Diagnosis, Fuzzy Logic, UAV, Unmanned aerial vehicle, Intelligent Techniques, prognosis, fault, remedy, Condition Monitoring Systems, ICMS

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2 An Integrated Logistics Model of Spare Parts Maintenance Planning within the Aviation Industry

Authors: Roy Fritzsche, Rainer Lasch

Abstract:

Avoidable unscheduled maintenance events and unnecessary spare parts deliveries are mostly caused by an incorrect choice of the underlying maintenance strategy. For a faster and more efficient supply of spare parts for aircrafts of an airline we examine options for improving the underlying logistics network integrated in an existing aviation industry network. This paper presents a dynamic prediction model as decision support for maintenance method selection considering requirements of an entire flight network. The objective is to guarantee a high supply of spare parts by an optimal interaction of various network levels and thus to reduce unscheduled maintenance events and minimize total costs. By using a prognostics-based preventive maintenance strategy unscheduled component failures are avoided for an increase in availability and reliability of the entire system. The model is intended for use in an aviation company that utilizes a structured planning process based on collected failures data of components.

Keywords: Reliability, prognosis, Aviation Industry, Preventive maintenance

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1 Identification of Complex Sense-antisense Gene's Module on 17q11.2 Associated with Breast Cancer Aggressiveness and Patient's Survival

Authors: O. Grinchuk, E. Motakis, V. Kuznetsov

Abstract:

Sense-antisense gene pair (SAGP) is a pair of two oppositely transcribed genes sharing a common region on a chromosome. In the mammalian genomes, SAGPs can be organized in more complex sense-antisense gene architectures (CSAGA) in which at least one gene could share loci with two or more antisense partners. Many dozens of CSAGAs can be found in the human genome. However, CSAGAs have not been systematically identified and characterized in context of their role in human diseases including cancers. In this work we characterize the structural-functional properties of a cluster of 5 genes –TMEM97, IFT20, TNFAIP1, POLDIP2 and TMEM199, termed TNFAIP1 / POLDIP2 module. This cluster is organized as CSAGA in cytoband 17q11.2. Affymetrix U133A&B expression data of two large cohorts (410 atients, in total) of breast cancer patients and patient survival data were used. For the both studied cohorts, we demonstrate (i) strong and reproducible transcriptional co-regulatory patterns of genes of TNFAIP1/POLDIP2 module in breast cancer cell subtypes and (ii) significant associations of TNFAIP1/POLDIP2 CSAGA with amplification of the CSAGA region in breast cancer, (ii) cancer aggressiveness (e.g. genetic grades) and (iv) disease free patient-s survival. Moreover, gene pairs of this module demonstrate strong synergetic effect in the prognosis of time of breast cancer relapse. We suggest that TNFAIP1/ POLDIP2 cluster can be considered as a novel type of structural-functional gene modules in the human genome.

Keywords: Breast Cancer, prognosis, survival analysis, Sense-antisense gene pair, complex genome architecture, TMEM97, IFT20, TNFAIP1, POLDIP2, TMEM199, transcription regulation

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