Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 2

bubble Related Publications

2 Hydrodynamics of Bubbly Flow in a Modified Reactor

Authors: M. Sivaiah, R. Parmar, S. K. Majumder

Abstract:

This article reports on hydrodynamic, mass transfer performances of fine bubble in a modified reactor. The quality of mixing in the modified reactor is discussed in the paper. Mass transfer efficiency based on quality of mixing is enunciated. To interpret the gas phase volume fraction and the quality of mixing is the empirical models for the modified system are developed.

Keywords: Hydrodynamics, Mixing, mass transfer, bubble, gas holdup, Downflow, gas-liquid

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1 A Preliminary Study of Drug Perfusion Enhancement by Microstreaming Induced by an Oscillating Microbubble

Authors: Kyehan Rhee, Jin Sun Oh, Kyung Ho Lee, S ang Gug Chung

Abstract:

Microbubbbles incorporating ultrasound have been used to increase the efficacy of targeted drug delivery, because microstreaming induced by cavitating bubbles affects the drug perfusion into the target cells and tissues. In order to clarify the physical effects of microstreaming on drug perfusion into tissues, a preliminary experimental study of perfusion enhancement by a stably oscillating microbubble was performed. Microstreaming was induced by an oscillating bubble at 15 kHz, and perfusion of dye into an agar phantom was optically measured by histology on agar phantom. Surface color intensity and the penetration length of dye in the agar phantom were increased more than 70% and 30%, respectively, due to the microstreaming induced by an oscillating bubble. The mass of dye perfused into a tissue phantom for 30 s was increased about 80% in the phantom with an oscillating bubble. This preliminary experiment shows the physical effects of steady streaming by an oscillating bubble can enhance the drug perfusion into the tissues while minimizing the biological effects.

Keywords: drug delivery, mass transfer, microstreaming, acoustic wave, bubble

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