Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 4

Publications

4 Comparison of Neural Network and Logistic Regression Methods to Predict Xerostomia after Radiotherapy

Authors: Hui-Min Ting, Tsair-Fwu Lee, Ming-Yuan Cho, Pei-Ju Chao, Chun-Ming Chang, Long-Chang Chen, Fu-Min Fang

Abstract:

To evaluate the ability to predict xerostomia after radiotherapy, we constructed and compared neural network and logistic regression models. In this study, 61 patients who completed a questionnaire about their quality of life (QoL) before and after a full course of radiation therapy were included. Based on this questionnaire, some statistical data about the condition of the patients’ salivary glands were obtained, and these subjects were included as the inputs of the neural network and logistic regression models in order to predict the probability of xerostomia. Seven variables were then selected from the statistical data according to Cramer’s V and point-biserial correlation values and were trained by each model to obtain the respective outputs which were 0.88 and 0.89 for AUC, 9.20 and 7.65 for SSE, and 13.7% and 19.0% for MAPE, respectively. These parameters demonstrate that both neural network and logistic regression methods are effective for predicting conditions of parotid glands.

Keywords: NPC, ANN, logistic regression, xerostomia.

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3 Model Parameters Estimating on Lyman–Kutcher–Burman Normal Tissue Complication Probability for Xerostomia on Head and Neck Cancer

Authors: Tsair-Fwu Lee , Hui-Min Ting , Pei-Ju Chao, Jing-Chuan Jiang, Min-Yuan Chao, Wen-Cheng Chen, Long-Chang Chen, Jia-Ming Wu

Abstract:

The purpose of this study is to derive parameters estimating for the Lyman–Kutcher–Burman (LKB) normal tissue complication probability (NTCP) model using analysis of scintigraphy assessments and quality of life (QoL) measurement questionnaires for the parotid gland (xerostomia). In total, 31 patients with head-and-neck (HN) cancer were enrolled. Salivary excretion factor (SEF) and EORTC QLQ-H&N35 questionnaires datasets are used for the NTCP modeling to describe the incidence of grade 4 xerostomia. Assuming that n= 1, NTCP fitted parameters are given as TD50= 43.6 Gy, m= 0.18 in SEF analysis, and as TD50= 44.1 Gy, m= 0.11 in QoL measurements, respectively. SEF and QoL datasets can validate the Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC) guidelines well, resulting in NPV-s of 100% for the both datasets and suggests that the QUANTEC 25/20Gy gland-spared guidelines are suitable for clinical used for the HN cohort to effectively avoid xerostomia.

Keywords: HN, NTCP, SEF, QoL, QUANTEC

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2 Applications of Artificial Neural Network to Building Statistical Models for Qualifying and Indexing Radiation Treatment Plans

Authors: Pei-Ju Chao, Tsair-Fwu Lee, Wei-Luen Huang, Long-Chang Chen, Te-Jen Su, Wen-Ping Chen

Abstract:

The main goal in this paper is to quantify the quality of different techniques for radiation treatment plans, a back-propagation artificial neural network (ANN) combined with biomedicine theory was used to model thirteen dosimetric parameters and to calculate two dosimetric indices. The correlations between dosimetric indices and quality of life were extracted as the features and used in the ANN model to make decisions in the clinic. The simulation results show that a trained multilayer back-propagation neural network model can help a doctor accept or reject a plan efficiently. In addition, the models are flexible and whenever a new treatment technique enters the market, the feature variables simply need to be imported and the model re-trained for it to be ready for use.

Keywords: neural network, dosimetric index, radiation treatment, tumor

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1 Active Power Filtering Implementation Using Photovoltaic System with Reduced Energy Storage Capacitor

Authors: Horng-Yuan Wu, Chin-Yuan Hsu, Tsair-Fwu Lee

Abstract:

A novel three-phase active power filter (APF) circuit with photovoltaic (PV) system to improve the quality of service and to reduce the capacity of energy storage capacitor is presented. The energy balance concept and sampling technique were used to simplify the calculation algorithm for the required utility source current and to control the voltage of the energy storage capacitor. The feasibility was verified by using the Pspice simulations and experiments. When the APF mode was used during non-operational period, not only the utilization rate, power factor and power quality could be improved, but also the capacity of energy storage capacitor could sparing. As the results, the advantages of the APF circuit are simplicity of control circuits, low cost, and good transient response.

Keywords: active power filter, sampling, energy-storagecapacitor, harmonic current, energy balance.

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