Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 14

Search results for: Esma Kocaoglu

14 Determination of the Inhibitory Effects of N-Methylpyrrole Derivatives on Glutathione Reductase Enzyme

Authors: Esma Kocaoglu, Oktay Talaz, Huseyin Cavdar, Murat Senturk, Deniz Eki̇nci̇


Glutathione reductase (GR) is a crucial antioxidant enzyme which is responsible for the maintenance of the antioxidant GSH (glutathione) molecule. Antimalarial effects of some chemical molecules are attributed to their inhibition of GR; thus inhibitors of this enzyme are expected to be promising candidates for the treatment of malaria. In this work, GR inhibitory properties of N-Methylpyrrole derivatives are reported. Firstly, GR was purified by means of affinity chromatography using 2’,5’-ADP-Sepharose 4B as ligand. Enzymatic activity was measured by Beutler’s method. Synthesis of the compounds was approved by thin layer chromatography and column chromatography. Different inhibitor concentrations were used and all compounds were tested in triplicate at each concentration used. It was found that all compounds have better inhibitory activity than the strong GR inhibitor N,N-bis(2-chloroethyl)-N-nitrosourea, especially three molecules, 8m, 8n, and 8q, are the best among them with low micromolar I₅₀ values. Findings of our study indicate that these Schiff base derivatives are strong GR inhibitors which can be used as leads for designation of novel antimalaria candidates.

Keywords: glutathione reductase, antimalaria, inhibitor, enzyme

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13 The Effect of Nanofiber Web on Thermal Conductivity, Air and Water Vapor Permeability

Authors: Ilkay Ozsev Yuksek, Nuray Ucar, Zeynep Esma Soygur, Yasemin Kucuk


In this study, composite fabrics with polyacrylonitrile electrospun nanofiber deposited onto quilted polyester fabric have been produced in order to control the isolation properties such as water vapor permeability, air permeability and thermal conductivity. Different nanofiber webs were manufactured by changing polymer concentration from 10% to 16% and by changing the deposition time from 1 to 3 hours. Presence of nanofiber layer on the quilted fabric results to an increase of an isolation, i.e., a decrease of the moisture vapor transport rates at 20%, decrease of thermal conductivity at 15% and a decrease of air permeability values at 50%.

Keywords: nanofiber/fabric composites, electrospinning, isolation, thermal conductivity, moisture vapor transport, air permeability

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12 Levels of Self-Efficiency and Participation Restrictions in Individuals Y and Z Generations

Authors: Sumeyye Belhan, Esma Ozkan, Mahmut Yaran


It is aimed to examine the self-efficacy and participation restrictions of the generations of Y and Z in the study. The participants were assessed with the Self-Efficacy Scale and the Participation Scale. There were 23 female and 17 male with a mean age of 29,17 ± 4,14 on the Y generation and 15 female and 25 male with a mean age of 13 ± 3,78 on the Z generation. The mean self-efficacy scores of the Y generation was 63.65 ± 11.01; and 65.80 ± 9.12 in the Z generation. There was no statistically significant difference between self-efficacy averages of Y and Z individuals (p > 0,05). The mean score indicating the participation limitations of the individuals on the Y generation was 11.28 ± 10.55; and 53,70 ± 18,05 in participants with Z generation. It was determined that there was a statistically significant difference between the participation restriction of Y and Z individuals (p < 0,001). The high level of participation restrictions on the Z generation suggests that these individuals are influenced by the situations such as family (financial resources, get permission) and school environment (exams, friends, adolescence period). This is reason it is believed that the planning and development of occupational therapy interventions would be beneficial to increase the participation of individuals in this population.

Keywords: environment, participation restriction, self efficiency, Y and Z generations

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11 Examination of Activity Preferences in Leisure Time of Y and Z Generations

Authors: Esma Ozkan, Sumeyye Belhan


The aim of this study is to examine the activity preferences of individuals in Y and Z generation. 90 Y and 90 Z generation individuals with a mean age of 32,76 ± 4,76 and 15,35 ± 2,61 years respectively, participated in the study and their activity preferences assessed. Results show that Y and Z generations preferred swimming and cycling among health related activities. For leisure activities, listening to music was favored by 87.5% and 100% of the Y and Z generations respectively. Reading (90%) was the most popular among Y generation and the second preferred for Z generation after technology (77.5%). Therefore, school based occupational therapy including activity analysis is key to enable adolescents to engage in proper activities. Inviting/visiting friends and family (socialization) was chosen by 100% of Y generation compared to 75% for Z generation. Since our culture and traditions are based on eating and socializing, these activities are well regarded across generations in Turkish society. Educational activities were preferred by 35% of Z generation compared to 75% in Y generation. Also, Z generation was more interested in history compared to sciences. Educational system changes, due to domestic politics and society, may have caused such differences among generations.

Keywords: activity preference, lifestyle, values, Y and Z generations

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10 Effectiveness of Natural Zeolite in Mitigating Alkali Silica Reaction Expansions

Authors: Esma Gizem Daskiran, Mehmet Mustafa Daskiran


This paper investigates the effectiveness of two natural zeolites in reducing expansion of concrete due to alkali-silica reaction. These natural zeolites have different reactive silica content. Three aggregates; two natural sand and one crushed stone aggregate were used while preparing mortar bars in accordance with accelerated mortar bar test method, ASTM C1260. Performance of natural zeolites are compared by examining the expansions due to alkali silica reaction. Natural zeolites added to the mixtures at %10 and %20 replacement levels by weight of cement. Natural zeolite with high reactive silica content had better performance on reducing expansions due to ASR. In this research, using high reactive zeolite at %20 replacement level was effective in mitigating expansions.

Keywords: alkali silica reaction, natural zeolite, durability, expansion

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9 Comparison of Sourcing Process in Supply Chain Operation References Model and Business Information Systems

Authors: Batuhan Kocaoglu


Although using powerful systems like ERP (Enterprise Resource Planning), companies still cannot benchmark their processes and measure their process performance easily based on predefined SCOR (Supply Chain Operation References) terms. The purpose of this research is to identify common and corresponding processes to present a conceptual model to model and measure the purchasing process of an organization. The main steps for the research study are: Literature review related to 'procure to pay' process in ERP system; Literature review related to 'sourcing' process in SCOR model; To develop a conceptual model integrating 'sourcing' of SCOR model and 'procure to pay' of ERP model. In this study, we examined the similarities and differences between these two models. The proposed framework is based on the assumptions that are drawn from (1) the body of literature, (2) the authors’ experience by working in the field of enterprise and logistics information systems. The modeling framework provides a structured and systematic way to model and decompose necessary information from conceptual representation to process element specification. This conceptual model will help the organizations to make quality purchasing system measurement instruments and tools. And offered adaptation issues for ERP systems and SCOR model will provide a more benchmarkable and worldwide standard business process.

Keywords: SCOR, ERP, procure to pay, sourcing, reference model

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8 Reduction Conditions of Briquetted Solid Wastes Generated by the Integrated Iron and Steel Plant

Authors: Gökhan Polat, Dicle Kocaoğlu Yılmazer, Muhlis Nezihi Sarıdede


Iron oxides are the main input to produce iron in integrated iron and steel plants. During production of iron from iron oxides, some wastes with high iron content occur. These main wastes can be classified as basic oxygen furnace (BOF) sludge, flue dust and rolling scale. Recycling of these wastes has a great importance for both environmental effects and reduction of production costs. In this study, recycling experiments were performed on basic oxygen furnace sludge, flue dust and rolling scale which contain 53.8%, 54.3% and 70.2% iron respectively. These wastes were mixed together with coke as reducer and these mixtures are pressed to obtain cylindrical briquettes. These briquettes were pressed under various compacting forces from 1 ton to 6 tons. Also, both stoichiometric and twice the stoichiometric cokes were added to investigate effect of coke amount on reduction properties of the waste mixtures. Then, these briquettes were reduced at 1000°C and 1100°C during 30, 60, 90, 120 and 150 min in a muffle furnace. According to the results of reduction experiments, the effect of compacting force, temperature and time on reduction ratio of the wastes were determined. It is found that 1 ton compacting force, 150 min reduction time and 1100°C are the optimum conditions to obtain reduction ratio higher than 75%.

Keywords: Coke, iron oxide wastes, recycling, reduction

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7 Production and Leftovers Usage Policies to Minimize Food Waste under Uncertain and Correlated Demand

Authors: Esma Birisci, Ronald McGarvey


One of the common problems in food service industry is demand uncertainty. This research presents a multi-criteria optimization approach to identify the efficient frontier of points lying between the minimum-waste and minimum-shortfall solutions within uncertain demand environment. It also addresses correlation across demands for items (e.g., hamburgers are often demanded with french fries). Reducing overproduction food waste (and its corresponding environmental impacts) and an aversion to shortfalls (leave some customer hungry) need to consider as two contradictory objectives in an all-you-care-to-eat environment food service operation. We identify optimal production adjustments relative to demand forecasts, demand thresholds for utilization of leftovers, and percentages of demand to be satisfied by leftovers, considering two alternative metrics for overproduction waste: mass; and greenhouse gas emissions. Demand uncertainty and demand correlations are addressed using a kernel density estimation approach. A statistical analysis of the changes in decision variable values across each of the efficient frontiers can then be performed to identify the key variables that could be modified to reduce the amount of wasted food at minimal increase in shortfalls. We illustrate our approach with an application to empirical data from Campus Dining Services operations at the University of Missouri.

Keywords: environmental studies, food waste, production planning, uncertain and correlated demand

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6 The Effect of Elastic-Resistance Training on Postural Control in Sedentary Women

Authors: Yagmur Kocaoglu, Nurtekin Erkmen


The aim of this study was to determine effects of elastic resistance band training on body composition and postural control in sedentary women. Thirty-four sedentary females participated voluntarily for this study. Subjects' age was 21.88 ± 1.63 years, height was 161.50 ± 4.45 cm, and weight was 59.47 ± 7.03 kg. Participants were randomly placed into one of two groups (Experimental = 17, Control = 17). The elastic resistance training program lasted 8 weeks with 3 sessions per week. Experimental Group performed elastic resistance band training with red color for first 3 weeks, blue color for second 3 weeks and for last 2 weeks. The subjects carried out exercises 3 set, 10-15 repetitions with 15 seconds rest between exercises. The rest between sets was 30 seconds. The subjects underwent a standard warm-up for 10 minutes in every session. The elastic resistance training lasted 40 minutes for each session. After the training, all subjects performed a standard cool down for 10 minutes in each session. After and before 8 weeks training period, all subjects in experimental group and control group participated body composition and postural control measurements. Independent t-Test and Mann Whitney U Test were conducted to compare differences between experimental and control groups. Paired t-Test and Wilcoxon Z Test were used to compare differences between pre and posttests. There is no significant difference between pre and posttests in BMI (p>0.05). After the elastic resistance training, postural control scores and body fat significantly decreased in experimental group (p<0.05). In conclusion, it can be concluded that elastic resistance training improves postural control and body composition in sedentary women.

Keywords: body composition, elastic resistance band, postural control, sedentary women

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5 Polymer Modification of Fine Grained Concretes Used in Textile Reinforced Cementitious Composites

Authors: Esma Gizem Daskiran, Mehmet Mustafa Daskiran, Mustafa Gencoglu


Textile reinforced cementitious composite (TRCC) is a development of a composite material where textile and fine-grained concrete (matrix) materials are used in combination. These matrices offer high performance properties in many aspects. To achieve high performance, polymer modified fine-grained concretes were used as matrix material which have high flexural strength. In this study, ten latex polymers and ten powder polymers were added to fine-grained concrete mixtures. These latex and powder polymers were added to the mixtures at different rates related to binder weight. Mechanical properties such as compressive and flexural strength were studied. Results showed that latex polymer and redispersible polymer modified fine-grained concretes showed different mechanical performance. A wide range of both latex and redispersible powder polymers were studied. As the addition rate increased compressive strength decreased for all mixtures. Flexural strength increased as the addition rate increased but significant enhancement was not observed through all mixtures.

Keywords: textile reinforced composite, cement, fine grained concrete, latex, redispersible powder

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4 Determination of Antioxidant Activity in Raphanus raphanistrum L.

Authors: Esma Hande Alıcı, Gülnur Arabacı


Antioxidants are compounds or systems that can safely interact with free radicals and terminate the chain reaction before vital molecules are damaged. The anti-oxidative effectiveness of these compounds depends on their chemical characteristics and physical location within a food (proximity to membrane phospholipids, emulsion interfaces, or in the aqueous phase). Antioxidants (e.g., flavonoids, phenolic acids, tannins, vitamin C, vitamin E) have diverse biological properties, such as antiinflammatory, anti-carcinogenic and anti-atherosclerotic effects, reduce the incidence of coronary diseases and contribute to the maintenance of gut health by the modulation of the gut microbial balance. Plants are excellent sources of antioxidants especially with their high content of phenolic compounds. Raphanus raphanistrum L., the wild radish, is a flowering plant in the family Brassicaceae. It grows in Asia and Mediterranean region. It has been introduced into most parts of the world. It spreads rapidly, and is often found growing on roadsides or in other places where the ground has been disturbed. It is an edible plant, in Turkey its fresh aerial parts are mostly consumed as a salad with olive oil and lemon juice after boiled. The leaves of the plant are also used as anti-rheumatic in traditional medicine. In this study, we determined the antioxidant capacity of two different solvent fractions (methanol and ethyl acetate) obtained from Raphanus raphanistrum L. plant leaves. Antioxidant capacity of the plant was introduced by using three different methods: DPPH radical scavenging activity, CUPRAC (Cupric Ion Reducing Antioxidant Capacity) activity and Reducing power activity.

Keywords: antioxidant activity, antioxidant capacity, Raphanis raphanistrum L., wild radish

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3 The Joint Attention Training as Early Occupational Therapy Intervention in Children with Autism

Authors: Sumeyye Belhan, Sema Gul Turk, Esma Ozkan, Mahmut Yaran


The purpose of the study is to examine the effect of joint attention training on communication skills and visual perception skills in autistic children. Eight children between 4 and six years of age participated in the study. Sociodemographic information form, Social Communication Questionnaire, Autism Behavior Checklist (ABC) and Motor-Free Visual Perception Test 4 (MVPT-4) were applied to the participants before intervention and after the intervention. Joint attention training was given three times a week for six weeks in total 18 sessions. Four of the children with autism who participate in the study (50%) were male, four (50%) were female and the mean age was 5,25±0,70. The Social Communication Scale score for children with autism was 13.62 ± 3.73 before the joint attention training and 11.37 ± 4.10 after the training. It was observed that social communication skills improved, but this improvement was not statistically significant (p > 0.05). Pre-education autistic children's Autism Behavioral Control score was 55,37 ± 9,94, whereas it was 40,12 ± 15,57 after training. There was a statistically significant improvement in sensory, relationship building, body and object use, language skills, social and self-care skills of autistic children in the autistic behavior checklist subscale after joint attention training (p < 0.05). MVPT 4 score before intervention in children with autism was 14.62 ± 6.65; and 19,50 ± 5,18 after the intervention. There was a statistically significant increase in visual perceptual skills without a motor in children with autism after the intervention (p < 0.05). This abstract is the pilot study of the joint attention training involving planned long-term (12 weeks) and more autistic children. A greater number of autistic children for longer period suggest that joint attention training will also lead to statistically significant improvements in social communication skills. It is thought that the joint attention training that is applied for a longer period in early childhood occupational therapy in children with autism will be beneficial for social communication, self-care skills and visual perception skills of autistic children.

Keywords: autism, joint attention, social communication, visual perception

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2 A Good Start for Digital Transformation of the Companies: A Literature and Experience-Based Predefined Roadmap

Authors: Batuhan Kocaoglu


Nowadays digital transformation is a hot topic both in service and production business. For the companies who want to stay alive in the following years, they should change how they do their business. Industry leaders started to improve their ERP (Enterprise Resource Planning) like backbone technologies to digital advances such as analytics, mobility, sensor-embedded smart devices, AI (Artificial Intelligence) and more. Selecting the appropriate technology for the related business problem also is a hot topic. Besides this, to operate in the modern environment and fulfill rapidly changing customer expectations, a digital transformation of the business is required and change the way the business runs, affect how they do their business. Even the digital transformation term is trendy the literature is limited and covers just the philosophy instead of a solid implementation plan. Current studies urge firms to start their digital transformation, but few tell us how to do. The huge investments scare companies with blur definitions and concepts. The aim of this paper to solidify the steps of the digital transformation and offer a roadmap for the companies and academicians. The proposed roadmap is developed based upon insights from the literature review, semi-structured interviews, and expert views to explore and identify crucial steps. We introduced our roadmap in the form of 8 main steps: Awareness; Planning; Operations; Implementation; Go-live; Optimization; Autonomation; Business Transformation; including a total of 11 sub-steps with examples. This study also emphasizes four dimensions of the digital transformation mainly: Readiness assessment; Building organizational infrastructure; Building technical infrastructure; Maturity assessment. Finally, roadmap corresponds the steps with three main terms used in digital transformation literacy as Digitization; Digitalization; and Digital Transformation. The resulted model shows that 'business process' and 'organizational issues' should be resolved before technology decisions and 'digitization'. Companies can start their journey with the solid steps, using the proposed roadmap to increase the success of their project implementation. Our roadmap is also adaptable for relevant Industry 4.0 and enterprise application projects. This roadmap will be useful for companies to persuade their top management for investments. Our results can be used as a baseline for further researches related to readiness assessment and maturity assessment studies.

Keywords: digital transformation, digital business, ERP, roadmap

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1 Investigation of Effectiveness of Activity-Based Postural Stability Training on Occupational Performance in Individuals with Visually Impairment: Pilot Study

Authors: Esma Ozkan, Esra Aki


The purpose of this study is an investigation of the effect of person-centered, based on activity postural stability training on occupational performance levels in visually impaired individuals. Postural stability norm studies were performed on healthy individuals who were between 18 and 35 years of age in the Biodex Balance System to determine inclusion criteria before blind individuals were included in the study. Healthy young adult subjects who participated in the study were 127 (81 female, 46 male) aged 18-35 years with an average age of 22,49 ± 3,66 years. Postural stability was assessed with the Biodex Stability System (Biodex Medical System, New York, USA). In case of standing on two legs; static and dynamic postural stability were assessed. Nine blind individuals (4 female, 5 male) were included in the study between 18 and 35 years of age, average age 26 ± 5,85 which had a standard value above the standard value in the data obtained from this normative study and have visual acuity less than 6/60. Socio-demographic information of the individuals was recorded. Before the intervention, individuals were administered Canada Occupational Performance Scale (COPM). According to COPM, the activities that are forced in the areas of self-care, leisure time and productivity are determined. In addition, the performance and satisfaction values of COPM were determined. Individuals Hacettepe University Department of Occupational Therapy, Vocational Rehabilitation Center conducted postural stability training based on activity for 2 days a week for 12 weeks. The same measurements and evaluations were repeated after the training. The dynamic overall stability deviation of the participants before the intervention was 3.64 ± 0.97 while it was recorded as 2.25 ± 0.68 after the intervention. After the training, postural stability values such as medio-lateral stability, anterior-posterior stability ve overall stability were significantly improved (p < 0,01) in the Biodex Balance System evaluations. Participants' pre-training COPM performance scores were 4,16 ± 1,08 point, while post-training COPM performance scores increased to 6,05 ± 1,13 point, similarly, COPM satisfaction scores were 4,16 ± 1,29 point to 6,50 ± 1,11 point. It was observed that visually impaired individuals included in the study had a statistically significant increase in the positive side in the values of COPM performance and satisfaction (p < 0,01). Person-centered postural stability training based on activity in visually impaired individuals is thought to increase the occupational performance of the individual with visually impairment. It is suggested that education should be person-centered, while postural stability training based on activity is planned in visually impaired individuals.

Keywords: occupational performance, occupational participation, postural stability, visually impaired

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