%0 Journal Article
	%A S. Buloyan and  V. Mamikonyan and  H. Hakobyan and  H. Harutyunyan and  H. Gasparyan
	%D 2014
	%J International Journal of Pharmacological and Pharmaceutical Sciences
	%B World Academy of Science, Engineering and Technology
	%I Open Science Index 96, 2014
	%T Grape Seed Extract in Prevention and Treatment of Liver Toxic Cirrhosis in Rats
	%U https://publications.waset.org/pdf/9999944
	%V 96
	%X The liver is the strongest regenerating organ of the
organism, and even with 2/3 surgically removed, it can regenerate
completely. Hence liver cirrhosis may only develop when the
regenerating system is off.
We present the results of a comparative study of structural and
functional characteristics of rat liver tissue under the conditions of
toxic liver cirrhosis development, induced by carbon tetrachloride,
and its prevention/treatment by natural compounds with antioxidant
and immune stimulating action. Studies were made on Wister rats,
weighing 120~140 g. Grape seeds extracts, separately and in
combination with well-known anticirrhotic drug ursodeoxycholic
acid (Urdoxa), have demonstrated effectiveness in prevention of liver
cirrhosis development and its treatment.

	%P 1362 - 1366