%0 Journal Article
	%A I. Boroňová and  J. Bernasovská and  J. Kľoc and  Z. Tomková and  E. Petrejčíková and  S. Mačeková and  J. Poráčová and  M. M. Blaščáková
	%D 2014
	%J International Journal of Bioengineering and Life Sciences
	%B World Academy of Science, Engineering and Technology
	%I Open Science Index 93, 2014
	%T Analysis of OPG Gene Polymorphism T245G (rs3134069) in Slovak Postmenopausal Women
	%U https://publications.waset.org/pdf/9999452
	%V 93
	%X Osteoporosis is a common multifactorial disease with
a strong genetic component characterized by reduced bone mass and
increased risk of fractures. Genetic factors play an important role in
the pathogenesis of osteoporosis. The aim of our study was to
identify the genotype and allele distribution of T245G polymorphism
in OPG gene in Slovak postmenopausal women. A total of 200
unrelated Slovak postmenopausal women with diagnosed
osteoporosis and 200 normal controls were genotyped for T245G
(rs3134069) polymorphism of OPG gene. Genotyping was performed
using the Custom Taqman®SNP Genotyping assays. Genotypes and
alleles frequencies showed no significant differences (p=0.5551;
p=0.6022). The results of the present study confirm the importance of
T245G polymorphism in OPG gene in the pathogenesis of
osteoporosis.

	%P 600 - 603