WASET
	%0 Journal Article
	%A I. Nur Hilwani and  R. Nasibah and  S. Nurdiana and  M. J. Norashirene
	%D 2014
	%J International Journal of Agricultural and Biosystems Engineering
	%B World Academy of Science, Engineering and Technology
	%I Open Science Index 93, 2014
	%T Gonadotoxic and Cytotoxic Effect of Induced obesity via Monosodium Glutamate on Mus musculus Testis Cytoarchitecture and Sperm Parameter
	%U https://publications.waset.org/pdf/9999350
	%V 93
	%X Impaired fertility may be the result of indirect
consumption of anti-fertility agents through food. Monosodium
glutamate (MSG) has been widely used as food additive, flavour
enhancer and included in vaccines. This study focuses in determining
the gonadotoxic and cytotoxic effect of MSG on selected sperm
parameters such as sperm viability, sperm membrane integrity and
testes cytoarchitecture of male mice via histological examination to
determine its effect on spermatogenesis. Twenty-four Mus musculus
were randomly divided into 4 groups and given intraperitoneal
injections (IP) daily for 14 days of different MSG concentrations at
250, 500 and 1000mg/kg MSG to body weight to induce obesity.
Saline was given to control group. Mice were sacrificed and analysis
revealed abnormalities in values for sperm parameters and damages
to testes cytoarchitecture of male mice. The results recorded
decreased viability (p<0.05) and integrity of sperm membrane
(p>0.05) with degenerative structures in seminiferous tubule of
testes. The results indicated various implications of MSG on male
mice reproductive system which has consequences in fertility
potential.

	%P 1000 - 1003